TreeWAS – Variant ID: rs13215574

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000
Chapter XV Pregnancy, childbirth and the puerperium	1.000	0.000
I20-I25 Ischaemic heart diseases	0.999	0.001
Chapter XX External causes of morbidity and mortality	0.999	0.001
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.999	0.001
I25 Chronic ischaemic heart disease	0.998	0.002
E10-E14 Diabetes mellitus	0.998	0.002
E11 Non-insulin-dependent diabetes mellitus	0.997	0.003
E11.9 Without complications	0.997	0.003
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.997	0.003
I25.2 Old myocardial infarction	0.989	0.011
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.987	0.013
I05-I09 Chronic rheumatic heart diseases	0.985	0.015
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.985	0.015
E65-E68 Obesity and other hyperalimentation	0.983	0.017
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.982	0.018
I10-I15 Hypertensive diseases	0.981	0.019
Y86 Sequelae of other accidents	0.978	0.022
I08 Multiple valve diseases	0.977	0.023
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.976	0.024
O47 False labour	0.973	0.027
Chapter II Neoplasms	0.971	0.029
E66 Obesity	0.970	0.030
I21 Acute myocardial infarction	0.967	0.033
M05-M14 Inflammatory polyarthropathies	0.966	0.034
M06 Other rheumatoid arthritis	0.962	0.038
M06.9 Rheumatoid arthritis, unspecified	0.960	0.040
O48 Prolonged pregnancy	0.956	0.044
E66.9 Obesity, unspecified	0.955	0.045
Chapter VI Diseases of the nervous system	0.947	0.053
T93 Sequelae of injuries of lower limb	0.946	0.054
I10 Essential (primary) hypertension	0.944	0.056
Chapter I Certain infectious and parasitic diseases	0.941	0.059
O47.1 False labour at or after 37 completed weeks of gestation	0.935	0.065
O60-O75 Complications of labour and delivery	0.935	0.065
I08.0 Disorders of both mitral and aortic valves	0.932	0.068
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.929	0.071
O34 Maternal care for known or suspected abnormality of pelvic organs	0.929	0.071
O00-O08 Pregnancy with abortive outcome	0.924	0.076
I30-I52 Other forms of heart disease	0.924	0.076
I21.9 Acute myocardial infarction, unspecified	0.922	0.078
I50 Heart failure	0.915	0.085
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.912	0.088
I50.1 Left ventricular failure	0.909	0.091
S60-S69 Injuries to the wrist and hand	0.906	0.094
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.899	0.101
S90-S99 Injuries to the ankle and foot	0.897	0.103
E00-E07 Disorders of thyroid gland	0.895	0.105
O42 Premature rupture of membranes	0.892	0.108
C43-C44 Melanoma and other malignant neoplasms of skin	0.889	0.111
I12 Hypertensive renal disease	0.888	0.112
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.888	0.112
T93.2 Sequelae of other fractures of lower limb	0.879	0.121
O34.2 Maternal care due to uterine scar from previous surgery	0.879	0.121
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.878	0.122
I25.8 Other forms of chronic ischaemic heart disease	0.871	0.129
T91 Sequelae of injuries of neck and trunk	0.869	0.131
C50-C50 Malignant neoplasm of breast	0.868	0.132
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.865	0.135
E20-E35 Disorders of other endocrine glands	0.864	0.136
O70 Perineal laceration during delivery	0.861	0.139
G90-G99 Other disorders of the nervous system	0.860	0.140
I25.9 Chronic ischaemic heart disease, unspecified	0.857	0.143
A30-A49 Other bacterial diseases	0.855	0.145
C60-C63 Malignant neoplasms of male genital organs	0.849	0.151
I25.1 Atherosclerotic heart disease	0.849	0.151
O02 Other abnormal products of conception	0.845	0.155
Y44 Agents primarily affecting blood constituents	0.840	0.160
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.840	0.160
I21.4 Acute subendocardial myocardial infarction	0.834	0.166
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.832	0.168
E07 Other disorders of thyroid	0.830	0.170
O69 Labour and delivery complicated by umbilical cord complications	0.828	0.172
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.825	0.175
I42 Cardiomyopathy	0.824	0.176
T92 Sequelae of injuries of upper limb	0.819	0.181
I22 Subsequent myocardial infarction	0.819	0.181
Y40 Systemic antibiotics	0.817	0.183
C44 Other malignant neoplasms of skin	0.817	0.183
E66.8 Other obesity	0.814	0.186
O03 Spontaneous abortion	0.814	0.186
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.813	0.187
E04 Other non-toxic goitre	0.810	0.190
D00-D09 In situ neoplasms	0.810	0.190
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.809	0.191
B95-B98 Bacterial, viral and other infectious agents	0.807	0.193
E11.4 With neurological complications	0.804	0.196
S66 Injury of muscle and tendon at wrist and hand level	0.803	0.197
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.802	0.198
O47.0 False labour before 37 completed weeks of gestation	0.801	0.199
M05 Seropositive rheumatoid arthritis	0.799	0.201
O40 Polyhydramnios	0.797	0.203
C50 Malignant neoplasm of breast	0.794	0.206
I12.9 Hypertensive renal disease without renal failure	0.793	0.207
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.792	0.208
E16 Other disorders of pancreatic internal secretion	0.791	0.209
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.791	0.209
M50-M54 Other dorsopathies	0.790	0.210
O72 Postpartum haemorrhage	0.788	0.212
G62 Other polyneuropathies	0.786	0.214
X50-X57 Overexertion, travel and privation	0.786	0.214
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.785	0.215
E40-E46 Malnutrition	0.784	0.216
S92 Fracture of foot, except ankle	0.784	0.216
E07.9 Disorder of thyroid, unspecified	0.783	0.217
W00-W19 Falls	0.783	0.217
O02.1 Missed abortion	0.782	0.218
S10-S19 Injuries to the neck	0.779	0.221
C44.7 Skin of lower limb, including hip	0.778	0.222
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.777	0.223
V80-V89 Other land transport accidents	0.777	0.223
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.775	0.225
Y52 Agents primarily affecting the cardiovascular system	0.775	0.225
X60-X84 Intentional self-harm	0.774	0.226
Q20-Q28 Congenital malformations of the circulatory system	0.773	0.227
O80-O84 Delivery	0.773	0.227
O41 Other disorders of amniotic fluid and membranes	0.773	0.227
O70.0 First degree perineal laceration during delivery	0.773	0.227
C44.4 Skin of scalp and neck	0.773	0.227
X58-X59 Accidental exposure to other and unspecified factors	0.771	0.229
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.771	0.229
C51-C58 Malignant neoplasms of female genital organs	0.770	0.229
I08.1 Disorders of both mitral and tricuspid valves	0.769	0.231
Y46 Antiepileptics and anti-Parkinsonism drugs	0.767	0.233
T20-T25 Burns and corrosions of external body surface, specified by site	0.767	0.233
M45-M49 Spondylopathies	0.766	0.234
D04 Carcinoma in situ of skin	0.765	0.235
Y60-Y69 Misadventures to patients during surgical and medical care	0.765	0.235
A50-A64 Infections with a predominantly sexual mode of transmission	0.764	0.236
Y85 Sequelae of transport accidents	0.763	0.237
Y43 Primarily systemic agents	0.762	0.238
I35 Nonrheumatic aortic valve disorders	0.761	0.239
T79-T79 Certain early complications of trauma	0.760	0.240
A00-A09 Intestinal infectious diseases	0.759	0.241
M80-M85 Disorders of bone density and structure	0.757	0.243
G80-G83 Cerebral palsy and other paralytic syndromes	0.756	0.244
C64-C68 Malignant neoplasms of urinary tract	0.756	0.244
G20-G26 Extrapyramidal and movement disorders	0.756	0.244
S50-S59 Injuries to the elbow and forearm	0.755	0.245
A41 Other septicaemia	0.755	0.245
Y41 Other systemic anti-infectives and antiparasitics	0.754	0.245
I60-I69 Cerebrovascular diseases	0.754	0.246
G95 Other diseases of spinal cord	0.754	0.246
O47.9 False labour, unspecified	0.753	0.247
E11.3 With ophthalmic complications	0.753	0.247
Y48 Anaesthetics and therapeutic gases	0.752	0.247
S70-S79 Injuries to the hip and thigh	0.750	0.250
Chapter XXII Codes for special purposes	0.750	0.250
T93.8 Sequelae of other specified injuries of lower limb	0.750	0.250
E04.9 Non-toxic goitre, unspecified	0.750	0.250
M54 Dorsalgia	0.749	0.251
V40-V49 Car occupant injured in transport accident	0.748	0.252
C61 Malignant neoplasm of prostate	0.746	0.254
O62 Abnormalities of forces of labour	0.744	0.256
T85 Complications of other internal prosthetic devices, implants and grafts	0.744	0.256
I33 Acute and subacute endocarditis	0.743	0.257
O69.2 Labour and delivery complicated by other cord entanglement	0.743	0.257
T91.3 Sequelae of injury of spinal cord	0.741	0.259
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.739	0.261
Y44.2 Anticoagulants	0.738	0.261
Chapter VIII Diseases of the ear and mastoid process	0.737	0.263
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.735	0.265
B96 Other bacterial agents as the cause of diseases classified to other chapters	0.735	0.265
T90 Sequelae of injuries of head	0.735	0.265
O35 Maternal care for known or suspected foetal abnormality and damage	0.733	0.267
G62.9 Polyneuropathy, unspecified	0.733	0.267
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.731	0.269
E16.2 Hypoglycaemia, unspecified	0.729	0.271
T93.1 Sequelae of fracture of femur	0.728	0.271
O44 Placenta praevia	0.728	0.272
O73 Retained placenta and membranes, without haemorrhage	0.727	0.272
M06.4 Inflammatory polyarthropathy	0.727	0.273
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.726	0.274
Q60-Q64 Congenital malformations of the urinary system	0.725	0.275
S60 Superficial injury of wrist and hand	0.725	0.275
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.723	0.277
G91 Hydrocephalus	0.723	0.277
C56 Malignant neoplasm of ovary	0.722	0.278
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.721	0.279
I25.3 Aneurysm of heart	0.720	0.279
E50-E64 Other nutritional deficiencies	0.720	0.280
T93.9 Sequelae of unspecified injury of lower limb	0.719	0.281
S64 Injury of nerves at wrist and hand level	0.718	0.282
M91-M94 Chondropathies	0.717	0.283
Y42.5 Other oestrogens and progestogens	0.717	0.283
I00-I02 Acute rheumatic fever	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
O85-O92 Complications predominantly related to the puerperium	0.717	0.283
I23 Certain current complications following acute myocardial infarction	0.716	0.283
S91 Open wound of ankle and foot	0.716	0.283
Y35-Y36 Legal intervention and operations of war	0.716	0.284
Y10-Y34 Event of undetermined intent	0.716	0.284
Y00-Y09 Assault	0.716	0.284
X85-X99 Assault	0.716	0.284
X30-X39 Exposure to forces of nature	0.716	0.284
X20-X29 Contact with venomous animals and plants	0.716	0.284
X10-X19 Contact with heat and hot substances	0.716	0.284
X00-X09 Exposure to smoke, fire and flames	0.716	0.284
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.716	0.284
W75-W84 Other accidental threats to breathing	0.716	0.284
W65-W74 Accidental drowning and submersion	0.716	0.284
W50-W64 Exposure to animate mechanical forces	0.716	0.284
V98-V99 Other and unspecified transport accidents	0.716	0.284
V95-V97 Air and space transport accidents	0.716	0.284
V90-V94 Water transport accidents	0.716	0.284
V70-V79 Bus occupant injured in transport accident	0.716	0.284
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.716	0.284
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.716	0.284
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.716	0.284
V01-V09 Pedestrian injured in transport accident	0.716	0.284
O45 Premature separation of placenta [abruptio placentae]	0.716	0.284
O33 Maternal care for known or suspected disproportion	0.716	0.284
O31 Complications specific to multiple gestation	0.716	0.284
M40-M43 Deforming dorsopathies	0.716	0.284
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.715	0.285
I25.6 Silent myocardial ischaemia	0.715	0.285
I25.4 Coronary artery aneurysm	0.715	0.285
I25.0 Atherosclerotic cardiovascular disease, so described	0.715	0.285
E12 Malnutrition-related diabetes mellitus	0.715	0.285
E11.8 With unspecified complications	0.715	0.285
E11.7 With multiple complications	0.715	0.285
E11.6 With other specified complications	0.715	0.285
E11.1 With ketoacidosis	0.715	0.285
E11.0 With coma	0.715	0.285
T33-T35 Frostbite	0.715	0.285
T26-T28 Burns and corrosions confined to eye and internal organs	0.715	0.285
T00-T07 Injuries involving multiple body regions	0.715	0.285
O46 Antepartum haemorrhage, not elsewhere classified	0.713	0.287
I12.0 Hypertensive renal disease with renal failure	0.712	0.288
M60-M63 Disorders of muscles	0.712	0.288
O32 Maternal care for known or suspected malpresentation of foetus	0.711	0.289
I15 Secondary hypertension	0.710	0.290
Y89 Sequelae of other external causes	0.707	0.293
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.707	0.293
V10-V19 Pedal cyclist injured in transport accident	0.707	0.293
I09 Other rheumatic heart diseases	0.706	0.294
I06 Rheumatic aortic valve diseases	0.706	0.294
T98 Sequelae of other and unspecified effects of external causes	0.706	0.294
T95 Sequelae of burns, corrosions and frostbite	0.706	0.294
T94 Sequelae of injuries involving multiple and unspecified body regions	0.706	0.294
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.706	0.294
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.706	0.294
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.706	0.294
X40-X49 Accidental poisoning by and exposure to noxious substances	0.706	0.294
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.706	0.294
S00-S09 Injuries to the head	0.705	0.295
E67 Other hyperalimentation	0.705	0.295
E68 Sequelae of hyperalimentation	0.705	0.295
E65 Localised adiposity	0.705	0.295
M00-M03 Infectious arthropathies	0.704	0.296
Y59 Other and unspecified vaccines and biological substances	0.704	0.296
Y58 Bacterial vaccines	0.704	0.296
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.704	0.296
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.704	0.296
Y53 Agents primarily affecting the gastro-intestinal system	0.704	0.296
Y50 Central nervous system stimulants, not elsewhere classified	0.704	0.296
Y49 Psychotropic drugs, not elsewhere classified	0.704	0.296
Y47 Sedatives, hypnotics and antianxiety drugs	0.704	0.296
I13 Hypertensive heart and renal disease	0.703	0.297
A04 Other bacterial intestinal infections	0.703	0.297
E29 Testicular dysfunction	0.702	0.298
M06.0 Seronegative rheumatoid arthritis	0.702	0.298
I08.9 Multiple valve disease, unspecified	0.701	0.299
I08.8 Other multiple valve diseases	0.701	0.299
I08.2 Disorders of both aortic and tricuspid valves	0.701	0.299
T91.2 Sequelae of other fracture of thorax and pelvis	0.700	0.300
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.699	0.301
G70-G73 Diseases of myoneural junction and muscle	0.698	0.302
O64 Obstructed labour due to malposition and malpresentation of foetus	0.697	0.303
A41.5 Septicaemia due to other Gram-negative organisms	0.696	0.304
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.696	0.304
C40-C41 Malignant neoplasms of bone and articular cartilage	0.696	0.304
E66.2 Extreme obesity with alveolar hypoventilation	0.696	0.304
E66.1 Drug-induced obesity	0.696	0.304
E66.0 Obesity due to excess calories	0.696	0.304
I05 Rheumatic mitral valve diseases	0.695	0.305
G61 Inflammatory polyneuropathy	0.694	0.306
B20-B24 Human immunodeficiency virus [HIV] disease	0.694	0.306
I21.X Presumed acute myicardial infaction (unconfirmed)	0.693	0.307
I21.3 Acute transmural myocardial infarction of unspecified site	0.693	0.307
M14 Arthropathies in other diseases classified elsewhere	0.692	0.307
M12 Other specific arthropathies	0.692	0.307
M09 Juvenile arthritis in diseases classified elsewhere	0.692	0.307
M08 Juvenile arthritis	0.692	0.307
G00-G09 Inflammatory diseases of the central nervous system	0.692	0.308
B25-B34 Other viral diseases	0.691	0.309
I22.9 Subsequent myocardial infarction of unspecified site	0.691	0.309
I21.1 Acute transmural myocardial infarction of inferior wall	0.691	0.309
C50.1 Central portion of breast	0.690	0.310
O70.2 Third degree perineal laceration during delivery	0.690	0.310
M06.8 Other specified rheumatoid arthritis	0.690	0.310
M06.3 Rheumatoid nodule	0.690	0.310
M06.2 Rheumatoid bursitis	0.690	0.310
M06.1 Adult-onset Still's disease	0.690	0.310
I31 Other diseases of pericardium	0.690	0.310
M70-M79 Other soft tissue disorders	0.689	0.311
I42.0 Dilated cardiomyopathy	0.689	0.311
C43 Malignant melanoma of skin	0.689	0.311
M06.98 Rheumatoid arthritis, unspecified (Other)	0.688	0.312
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.688	0.312
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.688	0.312
S61 Open wound of wrist and hand	0.688	0.312
O43 Placental disorders	0.686	0.314
V20-V29 Motorcycle rider injured in transport accident	0.685	0.315
S99 Other and unspecified injuries of ankle and foot	0.685	0.315
S40-S49 Injuries to the shoulder and upper arm	0.685	0.315
I24 Other acute ischaemic heart diseases	0.685	0.315
I21.0 Acute transmural myocardial infarction of anterior wall	0.684	0.316
T36-T50 Poisoning by drugs, medicaments and biological substances	0.684	0.316
I42.9 Cardiomyopathy, unspecified	0.684	0.316
A04.5 Campylobacter enteritis	0.683	0.317
O03.4 Incomplete, without complication	0.683	0.317
M86-M90 Other osteopathies	0.681	0.319
T92.9 Sequelae of unspecified injury of upper limb	0.681	0.319
A40 Streptococcal septicaemia	0.681	0.319
Y45.1 Salicylates	0.681	0.319
I21.2 Acute transmural myocardial infarction of other sites	0.680	0.320
M05.9 Seropositive rheumatoid arthritis, unspecified	0.680	0.320
O70.9 Perineal laceration during delivery, unspecified	0.679	0.321
S92.0 Fracture of calcaneus	0.678	0.321
D04.3 Skin of other and unspecified parts of face	0.678	0.322
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.678	0.322
W10 Fall on and from stairs and steps	0.678	0.322
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.678	0.322
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.678	0.322
T93.4 Sequelae of injury of nerve of lower limb	0.678	0.322
T93.0 Sequelae of open wound of lower limb	0.678	0.322
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.678	0.322
E13 Other specified diabetes mellitus	0.678	0.322
Y40.0 Penicillins	0.677	0.323
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.676	0.324
C50.9 Breast, unspecified	0.675	0.325
E11.5 With peripheral circulatory complications	0.675	0.325
O03.9 Complete or unspecified, without complication	0.675	0.325
B99-B99 Other infectious diseases	0.675	0.325
B85-B89 Pediculosis, acariasis and other infestations	0.675	0.325
B65-B83 Helminthiases	0.675	0.325
B50-B64 Protozoal diseases	0.675	0.325
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.675	0.325
A75-A79 Rickettsioses	0.675	0.325
A70-A74 Other diseases caused by chlamydiae	0.675	0.325
A65-A69 Other spirochaetal diseases	0.675	0.325
A20-A28 Certain zoonotic bacterial diseases	0.675	0.325
A15-A19 Tuberculosis	0.675	0.325
M54.5 Low back pain	0.675	0.325
T88 Other complications of surgical and medical care, not elsewhere classified	0.674	0.326
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters	0.674	0.326
S62 Fracture at wrist and hand level	0.672	0.327
A41.0 Septicaemia due to Staphylococcus aureus	0.672	0.328
O74 Complications of anaesthesia during labour and delivery	0.670	0.330
O71 Other obstetric trauma	0.670	0.330
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.670	0.330
O65 Obstructed labour due to maternal pelvic abnormality	0.670	0.330
O61 Failed induction of labour	0.670	0.330
O60 Preterm delivery	0.670	0.330
E22 Hyperfunction of pituitary gland	0.668	0.332
G30-G32 Other degenerative diseases of the nervous system	0.667	0.332
E28 Ovarian dysfunction	0.666	0.333
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level	0.666	0.334
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.666	0.334
O34.8 Maternal care for other abnormalities of pelvic organs	0.666	0.334
O34.7 Maternal care for abnormality of vulva and perineum	0.666	0.334
O34.6 Maternal care for abnormality of vagina	0.666	0.334
O34.5 Maternal care for other abnormalities of gravid uterus	0.666	0.334
O34.4 Maternal care for other abnormalities of cervix	0.666	0.334
O34.3 Maternal care for cervical incompetence	0.666	0.334
O34.1 Maternal care for tumour of corpus uteri	0.666	0.334
O34.0 Maternal care for congenital malformation of uterus	0.666	0.334
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.665	0.335
I25.5 Ischaemic cardiomyopathy	0.665	0.335
I11 Hypertensive heart disease	0.664	0.336
I45 Other conduction disorders	0.663	0.337
O08 Complications following abortion and ectopic and molar pregnancy	0.662	0.337
O07 Failed attempted abortion	0.662	0.337
O06 Unspecified abortion	0.662	0.337
O05 Other abortion	0.662	0.337
O01 Hydatidiform mole	0.662	0.337
O00 Ectopic pregnancy	0.662	0.337
I52 Other heart disorders in diseases classified elsewhere	0.662	0.338
I48 Atrial fibrillation and flutter	0.662	0.338
I43 Cardiomyopathy in diseases classified elsewhere	0.662	0.338
I41 Myocarditis in diseases classified elsewhere	0.662	0.338
I40 Acute myocarditis	0.662	0.338
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.662	0.338
I37 Pulmonary valve disorders	0.662	0.338
I36 Nonrheumatic tricuspid valve disorders	0.662	0.338
I32 Pericarditis in diseases classified elsewhere	0.662	0.338
O42.9 Premature rupture of membranes, unspecified	0.662	0.338
M11 Other crystal arthropathies	0.662	0.338
I30 Acute pericarditis	0.661	0.339
O72.0 Third-stage haemorrhage	0.659	0.341
G90 Disorders of autonomic nervous system	0.659	0.341
G35-G37 Demyelinating diseases of the central nervous system	0.658	0.342
I50.0 Congestive heart failure	0.658	0.342
O66 Other obstructed labour	0.657	0.342
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.657	0.343
S67 Crushing injury of wrist and hand	0.656	0.344
S20-S29 Injuries to the thorax	0.656	0.344
I50.9 Heart failure, unspecified	0.656	0.344
B15-B19 Viral hepatitis	0.656	0.344
W20-W49 Exposure to inanimate mechanical forces	0.655	0.345
T85.2 Mechanical complication of intraocular lens	0.655	0.345
E11.2 With renal complications	0.654	0.346
E23 Hypofunction and other disorders of pituitary gland	0.653	0.346
D07 Carcinoma in situ of other and unspecified genital organs	0.652	0.348
I35.1 Aortic (valve) insufficiency	0.652	0.348
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.651	0.349
S65 Injury of blood vessels at wrist and hand level	0.649	0.351
O69.8 Labour and delivery complicated by other cord complications	0.648	0.352
I70-I79 Diseases of arteries, arterioles and capillaries	0.648	0.352
Q21 Congenital malformations of cardiac septa	0.648	0.352
C62 Malignant neoplasm of testis	0.647	0.353
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.646	0.354
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.645	0.355
O94-O99 Other obstetric conditions, not elsewhere classified	0.644	0.356
B90-B94 Sequelae of infectious and parasitic diseases	0.644	0.356
S69 Other and unspecified injuries of wrist and hand	0.644	0.356
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.643	0.357
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.643	0.357
S98 Traumatic amputation of ankle and foot	0.643	0.357
S97 Crushing injury of ankle and foot	0.643	0.357
S96 Injury of muscle and tendon at ankle and foot level	0.643	0.357
S95 Injury of blood vessels at ankle and foot level	0.643	0.357
S94 Injury of nerves at ankle and foot level	0.643	0.357
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.643	0.357
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.642	0.358
E00 Congenital iodine-deficiency syndrome	0.642	0.358
E02 Subclinical iodine-deficiency hypothyroidism	0.642	0.358
I42.6 Alcoholic cardiomyopathy	0.641	0.359
A46 Erysipelas	0.641	0.359
I07 Rheumatic tricuspid valve diseases	0.641	0.359
Y45.0 Opioids and related analgesics	0.640	0.360
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.640	0.360
S92.7 Multiple fractures of foot	0.639	0.361
O42.2 Premature rupture of membranes, labour delayed by therapy	0.639	0.361
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.639	0.361
G60 Hereditary and idiopathic neuropathy	0.638	0.362
C34 Malignant neoplasm of bronchus and lung	0.638	0.362
Y88 Sequelae of surgical and medical care as external cause	0.638	0.362
T91.8 Sequelae of other specified injuries of neck and trunk	0.637	0.363
A63 Other predominantly sexually transmitted diseases, not elsewhere classified	0.637	0.363
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.636	0.363
Q35-Q37 Cleft lip and cleft palate	0.636	0.363
Q30-Q34 Congenital malformations of the respiratory system	0.636	0.363
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.636	0.363
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters	0.636	0.364
Q23 Congenital malformations of aortic and mitral valves	0.636	0.364
D37-D48 Neoplasms of uncertain or unknown behaviour	0.636	0.364
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.635	0.365
Q38-Q45 Other congenital malformations of the digestive system	0.634	0.365
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.634	0.366
H60-H62 Diseases of external ear	0.634	0.366
C07 Malignant neoplasm of parotid gland	0.633	0.367
Q80-Q89 Other congenital malformations	0.632	0.368
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level	0.631	0.369
O02.0 Blighted ovum and nonhydatidiform mole	0.631	0.369
C02 Malignant neoplasm of other and unspecified parts of tongue	0.630	0.370
C43.7 Malignant melanoma of lower limb, including hip	0.630	0.370
E15 Nondiabetic hypoglycaemic coma	0.630	0.370
E46 Unspecified protein-energy malnutrition	0.629	0.371
O30 Multiple gestation	0.629	0.371
T66-T78 Other and unspecified effects of external causes	0.629	0.371
Q50-Q56 Congenital malformations of genital organs	0.628	0.371
C50.4 Upper-outer quadrant of breast	0.628	0.372
E04.1 Non-toxic single thyroid nodule	0.628	0.372
C95 Leukaemia of unspecified cell type	0.628	0.372
A80-A89 Viral infections of the central nervous system	0.628	0.372
C69 Malignant neoplasm of eye and adnexa	0.627	0.373
T15-T19 Effects of foreign body entering through natural orifice	0.627	0.373
G20 Parkinson's disease	0.627	0.373
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.626	0.374
S90 Superficial injury of ankle and foot	0.625	0.375
X50 Overexertion and strenuous or repetitive movements	0.625	0.375
C84 Peripheral and cutaneous T-cell lymphomas	0.624	0.375
O81 Single delivery by forceps and vacuum extractor	0.624	0.376
Y57 Other and unspecified drugs and medicaments	0.624	0.376
Y40.9 Systemic antibiotic, unspecified	0.623	0.376
T91.9 Sequelae of unspecified injury of neck and trunk	0.623	0.377
T91.5 Sequelae of injury of intra-abdominal and pelvic organs	0.623	0.377
T91.4 Sequelae of injury of intrathoracic organs	0.623	0.377
T91.1 Sequelae of fracture of spine	0.623	0.377
T91.0 Sequelae of superficial injury and open wound of neck and trunk	0.623	0.377
G96 Other disorders of central nervous system	0.623	0.377
M84 Disorders of continuity of bone	0.623	0.377
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.623	0.377
Q00-Q07 Congenital malformations of the nervous system	0.622	0.378
S61.0 Open wound of finger(s) without damage to nail	0.622	0.378
A49 Bacterial infection of unspecified site	0.621	0.379
G64 Other disorders of peripheral nervous system	0.620	0.380
D04.2 Skin of ear and external auricular canal	0.620	0.380
T92.5 Sequelae of injury of muscle and tendon of upper limb	0.620	0.380
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.620	0.380
D04.7 Skin of lower limb, including hip	0.620	0.380
C50.2 Upper-inner quadrant of breast	0.619	0.381
E35 Disorders of endocrine glands in diseases classified elsewhere	0.619	0.381
E34 Other endocrine disorders	0.619	0.381
E32 Diseases of thymus	0.619	0.381
E31 Polyglandular dysfunction	0.619	0.381

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations