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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs187353341
log Bayes Factor = 19.0434
Chromosome 12   position 121,557,376  (GRCh37) Explore rs187353341 on Ensembl!
Variant rs187353341 is part of Cluster X0122

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
S00-S09 Injuries to the head
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.999 0.001 0.000
M20-M25 Other joint disorders
0.997 0.003 0.000
Chapter XIV Diseases of the genitourinary system
0.996 0.004 0.000
S00 Superficial injury of head
0.996 0.004 0.000
M25 Other joint disorders, not elsewhere classified
0.993 0.007 0.000
N30-N39 Other diseases of urinary system
0.993 0.007 0.000
I21 Acute myocardial infarction
0.991 0.009 0.000
Chapter V Mental and behavioural disorders
0.991 0.009 0.000
N32 Other disorders of bladder
0.984 0.016 0.000
M25.5 Pain in joint
0.983 0.017 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.983 0.017 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.982 0.018 0.000
I21.9 Acute myocardial infarction, unspecified
0.982 0.018 0.000
R19 Other symptoms and signs involving the digestive system and abdomen
0.981 0.019 0.000
R19.5 Other fecal abnormalities
0.980 0.020 0.000
N17-N19 Renal failure
0.980 0.020 0.000
E70-E90 Metabolic disorders
0.979 0.021 0.000
I25 Chronic ischaemic heart disease
0.979 0.021 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.977 0.023 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.977 0.023 0.000
I51 Complications and ill-defined descriptions of heart disease
0.971 0.029 0.000
E78.5 Hyperlipidaemia, unspecified
0.965 0.035 0.000
Chapter XXI Factors influencing health status and contact with health services
0.963 0.037 0.000
N18 Chronic renal failure
0.961 0.039 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.961 0.039 0.000
S60-S69 Injuries to the wrist and hand
0.958 0.042 0.000
S01 Open wound of head
0.957 0.043 0.000
S00.8 Superficial injury of other parts of head
0.945 0.055 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.941 0.059 0.000
I25.1 Atherosclerotic heart disease
0.939 0.061 0.000
M50-M54 Other dorsopathies
0.936 0.064 0.000
E78.0 Pure hypercholesterolaemia
0.935 0.065 0.000
I50 Heart failure
0.935 0.065 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.931 0.069 0.000
I20 Angina pectoris
0.928 0.072 0.000
S00.1 Contusion of eyelid and periocular area
0.926 0.074 0.000
I51.8 Other ill-defined heart diseases
0.921 0.079 0.000
Chapter XX External causes of morbidity and mortality
0.921 0.079 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.920 0.080 0.000
R15 Faecal incontinence
0.920 0.080 0.000
M65-M68 Disorders of synovium and tendon
0.919 0.081 0.000
N32.8 Other specified disorders of bladder
0.917 0.083 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.916 0.084 0.000
I50.0 Congestive heart failure
0.908 0.092 0.000
I25.2 Old myocardial infarction
0.907 0.093 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.907 0.093 0.000
I45 Other conduction disorders
0.905 0.095 0.000
S40-S49 Injuries to the shoulder and upper arm
0.902 0.098 0.000
M25.7 Osteophyte
0.900 0.100 0.000
N30 Cystitis
0.897 0.103 0.000
N32.3 Diverticulum of bladder
0.895 0.105 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.894 0.106 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.893 0.107 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.890 0.110 0.000
M51 Other intervertebral disk disorders
0.888 0.112 0.000
E83 Disorders of mineral metabolism
0.887 0.113 0.000
I49 Other cardiac arrhythmias
0.883 0.117 0.000
S64 Injury of nerves at wrist and hand level
0.879 0.121 0.000
I51.7 Cardiomegaly
0.877 0.123 0.000
I44 Atrioventricular and left bundle-branch block
0.877 0.123 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.876 0.124 0.000
S01.8 Open wound of other parts of head
0.876 0.124 0.000
S02 Fracture of skull and facial bones
0.875 0.125 0.000
S00.9 Superficial injury of head, part unspecified
0.872 0.128 0.000
N19 Unspecified renal failure
0.869 0.131 0.000
N18.9 Chronic renal failure, unspecified
0.868 0.132 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.868 0.132 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.867 0.133 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.867 0.133 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.861 0.139 0.000
M20 Acquired deformities of fingers and toes
0.861 0.139 0.000
N18.3 Chronic kidney disease, stage 3
0.859 0.141 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.859 0.141 0.000
I35 Nonrheumatic aortic valve disorders
0.859 0.141 0.000
Z04 Examination and observation for other reasons
0.858 0.142 0.000
N32.0 Bladder-neck obstruction
0.857 0.143 0.000
S06 Intracranial injury
0.853 0.147 0.000
T79-T79 Certain early complications of trauma
0.851 0.149 0.000
S09 Other and unspecified injuries of head
0.850 0.149 0.000
Chapter VII Diseases of the eye and adnexa
0.850 0.150 0.000
M25.77 Osteophyte (Ankle and foot)
0.850 0.150 0.000
M25.51 Pain in joint (Shoulder region)
0.847 0.153 0.000
Chapter VI Diseases of the nervous system
0.847 0.153 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.847 0.153 0.000
S00.0 Superficial injury of scalp
0.846 0.153 0.000
M67 Other disorders of synovium and tendon
0.844 0.156 0.000
R47-R49 Symptoms and signs involving speech and voice
0.843 0.157 0.000
I20.8 Other forms of angina pectoris
0.843 0.157 0.000
W00-W19 Falls
0.840 0.160 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.840 0.160 0.000
Z34 Supervision of normal pregnancy
0.838 0.162 0.000
M25.53 Pain in joint (Forearm)
0.837 0.163 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.835 0.165 0.000
M91-M94 Chondropathies
0.834 0.166 0.000
T90 Sequelae of injuries of head
0.833 0.167 0.000
I38 Endocarditis, valve unspecified
0.829 0.171 0.000
Chapter VIII Diseases of the ear and mastoid process
0.829 0.171 0.000
Z36 Antenatal screening
0.823 0.177 0.000
R10 Abdominal and pelvic pain
0.821 0.179 0.000
R19.0 Intra-abdominal and pelvic swelling, mass and lump
0.819 0.181 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.818 0.182 0.000
M80-M85 Disorders of bone density and structure
0.816 0.184 0.000
I45.1 Other and unspecified right bundle-branch block
0.816 0.184 0.000
S50-S59 Injuries to the elbow and forearm
0.816 0.184 0.000
R19.4 Change in bowel habit
0.814 0.186 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.814 0.186 0.000
S42 Fracture of shoulder and upper arm
0.813 0.187 0.000
M51.2 Other specified intervertebral disk displacement
0.812 0.188 0.000
R01 Cardiac murmurs and other cardiac sounds
0.809 0.191 0.000
I44.7 Left bundle-branch block, unspecified
0.807 0.193 0.000
N30.9 Cystitis, unspecified
0.806 0.194 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.805 0.195 0.000
N40-N51 Diseases of male genital organs
0.803 0.197 0.000
I34 Nonrheumatic mitral valve disorders
0.803 0.197 0.000
S01.1 Open wound of eyelid and periocular area
0.799 0.201 0.000
S64.4 Injury of digital nerve of other finger
0.799 0.201 0.000
E83.4 Disorders of magnesium metabolism
0.798 0.202 0.000
N00-N08 Glomerular diseases
0.797 0.203 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.796 0.204 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.795 0.205 0.000
Z34.9 Supervision of normal pregnancy, unspecified
0.794 0.206 0.000
Z12 Special screening examination for neoplasms
0.794 0.206 0.000
Z13 Special screening examination for other diseases and disorders
0.793 0.207 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.793 0.207 0.000
Q60-Q64 Congenital malformations of the urinary system
0.791 0.208 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.790 0.210 0.000
M67.8 Other specified disorders of synovium and tendon
0.790 0.210 0.000
R10.3 Pain localised to other parts of lower abdomen
0.789 0.211 0.000
T93 Sequelae of injuries of lower limb
0.789 0.211 0.000
M25.56 Pain in joint (Lower leg)
0.787 0.213 0.000
S01.2 Open wound of nose
0.785 0.215 0.000
M20.1 Hallux valgus (acquired)
0.784 0.216 0.000
M25.8 Other specified joint disorders
0.783 0.217 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.783 0.217 0.000
R50-R69 General symptoms and signs
0.783 0.217 0.000
I05-I09 Chronic rheumatic heart diseases
0.782 0.218 0.000
F30-F39 Mood [affective] disorders
0.781 0.219 0.000
N25-N29 Other disorders of kidney and ureter
0.778 0.222 0.000
M22 Disorders of patella
0.778 0.222 0.000
M25.59 Pain in joint (Site unspecified)
0.777 0.222 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.776 0.224 0.000
O20 Haemorrhage in early pregnancy
0.775 0.225 0.000
E83.5 Disorders of calcium metabolism
0.774 0.226 0.000
M21 Other acquired deformities of limbs
0.774 0.226 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.774 0.226 0.000
N18.0 End-stage renal disease
0.774 0.226 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.773 0.227 0.000
E20-E35 Disorders of other endocrine glands
0.768 0.232 0.000
M24 Other specific joint derangements
0.767 0.233 0.000
I22 Subsequent myocardial infarction
0.767 0.233 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.767 0.233 0.000
N18.5 Chronic kidney disease, stage 5
0.766 0.234 0.000
M25.0 Haemarthrosis
0.765 0.235 0.000
N32.1 Vesicointestinal fistula
0.765 0.235 0.000
F60-F69 Disorders of adult personality and behaviour
0.762 0.238 0.000
N36 Other disorders of urethra
0.762 0.238 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.761 0.239 0.000
O16 Unspecified maternal hypertension
0.760 0.240 0.000
F10.3 Withdrawal state
0.757 0.243 0.000
G90-G99 Other disorders of the nervous system
0.757 0.243 0.000
I73 Other peripheral vascular diseases
0.756 0.243 0.000
M86-M90 Other osteopathies
0.756 0.244 0.000
H30-H36 Disorders of choroid and retina
0.756 0.244 0.000
R04 Haemorrhage from respiratory passages
0.755 0.245 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.755 0.245 0.000
I50.9 Heart failure, unspecified
0.755 0.245 0.000
S80-S89 Injuries to the knee and lower leg
0.753 0.247 0.000
N34 Urethritis and urethral syndrome
0.751 0.249 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.749 0.251 0.000
R01.1 Cardiac murmur, unspecified
0.749 0.251 0.000
S20-S29 Injuries to the thorax
0.748 0.252 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.747 0.253 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.746 0.254 0.000
N48 Other disorders of penis
0.746 0.254 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.745 0.254 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.745 0.255 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.744 0.256 0.000
F10.0 Acute intoxication
0.744 0.256 0.000
Z04.3 Examination and observation following other accident
0.744 0.256 0.000
S09.9 Unspecified injury of head
0.743 0.257 0.000
N32.9 Bladder disorder, unspecified
0.743 0.257 0.000
W20-W49 Exposure to inanimate mechanical forces
0.742 0.258 0.000
I33 Acute and subacute endocarditis
0.742 0.258 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.740 0.260 0.000
I25.5 Ischaemic cardiomyopathy
0.739 0.261 0.000
M05-M14 Inflammatory polyarthropathies
0.739 0.261 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.739 0.261 0.000
S00.3 Superficial injury of nose
0.738 0.262 0.000
Chapter XXII Codes for special purposes
0.733 0.267 0.000
O00-O08 Pregnancy with abortive outcome
0.731 0.269 0.000
M00-M03 Infectious arthropathies
0.731 0.269 0.000
E50-E64 Other nutritional deficiencies
0.730 0.270 0.000
N30.1 Interstitial cystitis (chronic)
0.730 0.270 0.000
I20.9 Angina pectoris, unspecified
0.730 0.270 0.000
M31 Other necrotising vasculopathies
0.730 0.270 0.000
I25.3 Aneurysm of heart
0.729 0.271 0.000
I73.9 Peripheral vascular disease, unspecified
0.729 0.271 0.000
I45.6 Preexcitation syndrome
0.728 0.272 0.000
F99-F99 Unspecified mental disorder
0.727 0.273 0.000
Z04.8 Examination and observation for other specified reasons
0.727 0.273 0.000
N18.4 Chronic kidney disease, stage 4
0.726 0.274 0.000
E88 Other metabolic disorders
0.725 0.275 0.000
M50 Cervical disk disorders
0.724 0.276 0.000
I20.1 Angina pectoris with documented spasm
0.724 0.276 0.000
F01 Vascular dementia
0.723 0.277 0.000
Z13.0 Special screening examination for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.723 0.277 0.000
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum
0.723 0.277 0.000
I49.4 Other and unspecified premature depolarisation
0.723 0.277 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.722 0.278 0.000
R40 Somnolence, stupor and coma
0.722 0.278 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.722 0.278 0.000
I35.8 Other aortic valve disorders
0.721 0.279 0.000
T66-T78 Other and unspecified effects of external causes
0.721 0.279 0.000
H53-H54 Visual disturbances and blindness
0.721 0.279 0.000
M25.76 Osteophyte (Lower leg)
0.720 0.280 0.000
O36 Maternal care for other known or suspected foetal problems
0.720 0.280 0.000
M65 Synovitis and tenosynovitis
0.720 0.280 0.000
M40-M43 Deforming dorsopathies
0.719 0.280 0.000
S01.0 Open wound of scalp
0.719 0.281 0.000
I49.9 Cardiac arrhythmia, unspecified
0.718 0.282 0.000
N18.2 Chronic kidney disease, stage 2
0.718 0.282 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
S08 Traumatic amputation of part of head
0.717 0.283 0.000
S07 Crushing injury of head
0.717 0.283 0.000
S05 Injury of eye and orbit
0.717 0.283 0.000
S04 Injury of cranial nerves
0.717 0.283 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I30 Acute pericarditis
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.716 0.284 0.000
R04.2 Haemoptysis
0.716 0.284 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.715 0.285 0.000
M34 Systemic sclerosis
0.715 0.285 0.000
M33 Dermatopolymyositis
0.715 0.285 0.000
M32 Systemic lupus erythematosus
0.715 0.285 0.000
M30 Polyarteritis nodosa and related conditions
0.715 0.285 0.000
F80-F89 Disorders of psychological development
0.715 0.285 0.000
M94 Other disorders of cartilage
0.715 0.285 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.715 0.285 0.000
Z36.3 Antenatal screening for malformations using ultrasound and other physical methods
0.714 0.286 0.000
S00.7 Multiple superficial injuries of head
0.714 0.286 0.000
S00.5 Superficial injury of lip and oral cavity
0.714 0.286 0.000
S00.4 Superficial injury of ear
0.714 0.286 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.714 0.286 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.714 0.286 0.000
S06.0 Concussion
0.713 0.287 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.713 0.287 0.000
M25.9 Joint disorder, unspecified
0.712 0.288 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.712 0.288 0.000
M25.3 Other instability of joint
0.712 0.288 0.000
M25.2 Flail joint
0.712 0.288 0.000
M25.1 Fistula of joint
0.712 0.288 0.000
N37 Urethral disorders in diseases classified elsewhere
0.712 0.288 0.000
N33 Bladder disorders in diseases classified elsewhere
0.712 0.288 0.000
Z36.8 Other antenatal screening
0.711 0.289 0.000
R00 Abnormalities of heart beat
0.711 0.289 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.710 0.289 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.710 0.289 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.710 0.290 0.000
F70-F79 Mental retardation
0.710 0.290 0.000
S02.0 Fracture of vault of skull
0.710 0.290 0.000
Z04.1 Examination and observation following transport accident
0.709 0.290 0.000
Q66 Congenital deformities of feet
0.709 0.291 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.709 0.291 0.000
T90.9 Sequelae of unspecified injury of head
0.706 0.294 0.000
N31.8 Other neuromuscular dysfunction of bladder
0.706 0.294 0.000
N32.4 Rupture of bladder, nontraumatic
0.705 0.295 0.000
N32.2 Vesical fistula, not elsewhere classified
0.705 0.295 0.000
M25.58 Pain in joint (Other)
0.705 0.295 0.000
M25.52 Pain in joint (Upper arm)
0.705 0.295 0.000
I49.5 Sick sinus syndrome
0.705 0.295 0.000
S02.1 Fracture of base of skull
0.704 0.296 0.000
R19.6 Halitosis
0.703 0.297 0.000
R19.3 Abdominal rigidity
0.703 0.297 0.000
R19.2 Visible peristalsis
0.703 0.297 0.000
R19.1 Abnormal bowel sounds
0.703 0.297 0.000
G30-G32 Other degenerative diseases of the nervous system
0.703 0.297 0.000
N99-N99 Other disorders of the genitourinary system
0.703 0.297 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.703 0.297 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.703 0.297 0.000
E85 Amyloidosis
0.702 0.298 0.000
E84 Cystic fibrosis
0.702 0.298 0.000
E79 Disorders of purine and pyrimidine metabolism
0.702 0.298 0.000
E77 Disorders of glycoprotein metabolism
0.702 0.298 0.000
E76 Disorders of glycosaminoglycan metabolism
0.702 0.298 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.702 0.298 0.000
E74 Other disorders of carbohydrate metabolism
0.702 0.298 0.000
E73 Lactose intolerance
0.702 0.298 0.000
E72 Other disorders of amino-acid metabolism
0.702 0.298 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.702 0.298 0.000
E70 Disorders of aromatic amino-acid metabolism
0.702 0.298 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.702 0.298 0.000
I25.6 Silent myocardial ischaemia
0.702 0.298 0.000
I25.4 Coronary artery aneurysm
0.702 0.298 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.702 0.298 0.000
S42.1 Fracture of scapula
0.702 0.298 0.000
S64.2 Injury of radial nerve at wrist and hand level
0.702 0.298 0.000
E78.8 Other disorders of lipoprotein metabolism
0.700 0.299 0.000
E78.6 Lipoprotein deficiency
0.700 0.299 0.000
E78.4 Other hyperlipidaemia
0.700 0.299 0.000
E78.3 Hyperchylomicronaemia
0.700 0.299 0.000
E78.1 Pure hyperglyceridaemia
0.700 0.299 0.000
O85-O92 Complications predominantly related to the puerperium
0.700 0.300 0.000
S01.3 Open wound of ear
0.700 0.300 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.699 0.300 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.699 0.300 0.000
S60 Superficial injury of wrist and hand
0.699 0.301 0.000
S42.3 Fracture of shaft of humerus
0.698 0.302 0.000
S52 Fracture of forearm
0.697 0.303 0.000
R49 Voice disturbances
0.697 0.303 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.696 0.303 0.000
H55-H59 Other disorders of eye and adnexa
0.696 0.304 0.000
H35 Other retinal disorders
0.696 0.304 0.000
I51.6 Cardiovascular disease, unspecified
0.696 0.304 0.000
I51.5 Myocardial degeneration
0.696 0.304 0.000
I51.4 Myocarditis, unspecified
0.696 0.304 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.696 0.304 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.696 0.304 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.696 0.304 0.000
I51.0 Cardiac septal defect, acquired
0.696 0.304 0.000
I46 Cardiac arrest
0.696 0.304 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.695 0.305 0.000
S01.5 Open wound of lip and oral cavity
0.695 0.305 0.000
Q63 Other congenital malformations of kidney
0.695 0.305 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.695 0.305 0.000
M53 Other dorsopathies, not elsewhere classified
0.694 0.306 0.000
R55 Syncope and collapse
0.694 0.306 0.000
F31 Bipolar affective disorder
0.693 0.307 0.000
Y86 Sequelae of other accidents
0.693 0.307 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.693 0.307 0.000
R10.0 Acute abdomen
0.692 0.308 0.000
F10.2 Dependence syndrome
0.692 0.308 0.000
S61 Open wound of wrist and hand
0.692 0.308 0.000
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level
0.692 0.308 0.000
Z02 Examination and encounter for administrative purposes
0.691 0.309 0.000
H60-H62 Diseases of external ear
0.690 0.310 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.690 0.310 0.000
N18.8 Other chronic renal failure
0.689 0.311 0.000
N18.1 Chronic kidney disease, stage 1
0.689 0.311 0.000
T92 Sequelae of injuries of upper limb
0.689 0.311 0.000
R52 Pain, not elsewhere classified
0.689 0.311 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.689 0.311 0.000
E78.2 Mixed hyperlipidaemia
0.688 0.311 0.000
Q50-Q56 Congenital malformations of genital organs
0.688 0.312 0.000
M84 Disorders of continuity of bone
0.688 0.312 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.687 0.313 0.000
S69 Other and unspecified injuries of wrist and hand
0.687 0.313 0.000
S67 Crushing injury of wrist and hand
0.687 0.313 0.000
S65 Injury of blood vessels at wrist and hand level
0.687 0.313 0.000
S01.7 Multiple open wounds of head
0.686 0.313 0.000
S01.4 Open wound of cheek and temporomandibular area
0.686 0.313 0.000
I35.0 Aortic (valve) stenosis
0.686 0.314 0.000
N31.2 Flaccid neuropathic bladder, not elsewhere classified
0.686 0.314 0.000
O20.0 Threatened abortion
0.685 0.315 0.000
R46 Symptoms and signs involving appearance and behaviour
0.685 0.315 0.000
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation
0.685 0.315 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.684 0.316 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.684 0.316 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.683 0.316 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.683 0.317 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.682 0.318 0.000
W19 Unspecified fall
0.682 0.318 0.000
N30.2 Other chronic cystitis
0.682 0.318 0.000
R73 Elevated blood glucose level
0.682 0.318 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.681 0.318 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.681 0.319 0.000
S02.8 Fractures of other skull and facial bones
0.680 0.320 0.000
M25.54 Pain in joint (Hand)
0.679 0.320 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.679 0.321 0.000
S90-S99 Injuries to the ankle and foot
0.679 0.321 0.000
S06.8 Other intracranial injuries
0.678 0.321 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.678 0.322 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.678 0.322 0.000
M45-M49 Spondylopathies
0.676 0.324 0.000
T98 Sequelae of other and unspecified effects of external causes
0.674 0.326 0.000
T95 Sequelae of burns, corrosions and frostbite
0.674 0.326 0.000
T91 Sequelae of injuries of neck and trunk
0.674 0.326 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.674 0.326 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.674 0.326 0.000
W13 Fall from, out of or through building or structure
0.674 0.326 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.674 0.326 0.000
R12 Heartburn
0.673 0.327 0.000
I34.1 Mitral (valve) prolapse
0.673 0.327 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.673 0.327 0.000
R54 Senility
0.673 0.327 0.000
N30.0 Acute cystitis
0.672 0.328 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.671 0.329 0.000
I10-I15 Hypertensive diseases
0.671 0.329 0.000
S06.2 Diffuse brain injury
0.670 0.329 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.670 0.330 0.000
H34 Retinal vascular occlusions
0.670 0.330 0.000
X60-X84 Intentional self-harm
0.670 0.330 0.000
V80-V89 Other land transport accidents
0.670 0.330 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.669 0.331 0.000
F03 Unspecified dementia
0.668 0.332 0.000
R02 Gangrene, not elsewhere classified
0.668 0.332 0.000
Z10 Routine general health check-up of defined subpopulation
0.667 0.333 0.000
I49.8 Other specified cardiac arrhythmias
0.665 0.334 0.000
N03 Chronic nephritic syndrome
0.665 0.335 0.000
I08 Multiple valve diseases
0.664 0.336 0.000
N73 Other female pelvic inflammatory diseases
0.662 0.338 0.000
R20 Disturbances of skin sensation
0.660 0.339 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.660 0.340 0.000
Y35-Y36 Legal intervention and operations of war
0.660 0.340 0.000
Y10-Y34 Event of undetermined intent
0.660 0.340 0.000
Y00-Y09 Assault
0.660 0.340 0.000
X85-X99 Assault
0.660 0.340 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.660 0.340 0.000
X50-X57 Overexertion, travel and privation
0.660 0.340 0.000
X30-X39 Exposure to forces of nature
0.660 0.340 0.000
X20-X29 Contact with venomous animals and plants
0.660 0.340 0.000
X10-X19 Contact with heat and hot substances
0.660 0.340 0.000
X00-X09 Exposure to smoke, fire and flames
0.660 0.340 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.660 0.340 0.000
W75-W84 Other accidental threats to breathing
0.660 0.340 0.000
W65-W74 Accidental drowning and submersion
0.660 0.340 0.000
W50-W64 Exposure to animate mechanical forces
0.660 0.340 0.000
V98-V99 Other and unspecified transport accidents
0.660 0.340 0.000
V95-V97 Air and space transport accidents
0.660 0.340 0.000
V90-V94 Water transport accidents
0.660 0.340 0.000
V70-V79 Bus occupant injured in transport accident
0.660 0.340 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.660 0.340 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.660 0.340 0.000
V40-V49 Car occupant injured in transport accident
0.660 0.340 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.660 0.340 0.000
V20-V29 Motorcycle rider injured in transport accident
0.660 0.340 0.000
V01-V09 Pedestrian injured in transport accident
0.660 0.340 0.000
R47 Speech disturbances, not elsewhere classified
0.660 0.340 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.660 0.340 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.660 0.340 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.660 0.340 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.660 0.340 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.660 0.340 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.660 0.340 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.660 0.340 0.000
F11 Mental and behavioural disorders due to use of opioids
0.660 0.340 0.000
I49.0 Ventricular fibrillation and flutter
0.660 0.340 0.000
I20.0 Unstable angina
0.659 0.341 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.659 0.341 0.000
M66 Spontaneous rupture of synovium and tendon
0.659 0.341 0.000
O30 Multiple gestation
0.658 0.342 0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract
0.658 0.342 0.000
N48.0 Leukoplakia of penis
0.657 0.343 0.000
S42.9 Fracture of shoulder girdle, part unspecified
0.657 0.343 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.657 0.343 0.000
Q80-Q89 Other congenital malformations
0.657 0.343 0.000
Q35-Q37 Cleft lip and cleft palate
0.657 0.343 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.657 0.343 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.657 0.343 0.000
Q00-Q07 Congenital malformations of the nervous system
0.657 0.343 0.000
H65-H75 Diseases of middle ear and mastoid
0.657 0.343 0.000
S80 Superficial injury of lower leg
0.657 0.343 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.656 0.343 0.000
N35 Urethral stricture
0.656 0.344 0.000
H90-H95 Other disorders of ear
0.656 0.344 0.000
T90.5 Sequelae of intracranial injury
0.655 0.345 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.655 0.345 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.654 0.346 0.000
I44.1 Atrioventricular block, second degree
0.653 0.347 0.000
Z34.8 Supervision of other normal pregnancy
0.653 0.347 0.000
R45 Symptoms and signs involving emotional state
0.653 0.347 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.653 0.347 0.000
H53 Visual disturbances
0.653 0.347 0.000
Z39 Postpartum care and examination
0.652 0.348 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.652 0.348 0.000
W08 Fall involving other furniture
0.650 0.350 0.000
O15 Eclampsia
0.650 0.350 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.650 0.350 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.650 0.350 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.650 0.350 0.000
W25 Contact with sharp glass
0.650 0.350 0.000
S70-S79 Injuries to the hip and thigh
0.650 0.350 0.000
V10-V19 Pedal cyclist injured in transport accident
0.649 0.350 0.000
S40 Superficial injury of shoulder and upper arm
0.649 0.350 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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