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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs34734558
log Bayes Factor = 8.30255
Chromosome 4   position 100,530,143  (GRCh37) Explore rs34734558 on Ensembl!
Variant rs34734558 is part of Cluster X0191

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M50-M54 Other dorsopathies
0.999 0.001 0.000
M45-M49 Spondylopathies
0.999 0.001 0.000
S00-S09 Injuries to the head
0.999 0.001 0.000
S09 Other and unspecified injuries of head
0.996 0.004 0.000
M47 Spondylosis
0.996 0.004 0.000
S40-S49 Injuries to the shoulder and upper arm
0.995 0.005 0.000
S09.9 Unspecified injury of head
0.994 0.006 0.000
M54 Dorsalgia
0.993 0.007 0.000
Chapter XX External causes of morbidity and mortality
0.992 0.008 0.000
Chapter VI Diseases of the nervous system
0.971 0.029 0.000
M20-M25 Other joint disorders
0.969 0.031 0.000
M54.5 Low back pain
0.968 0.032 0.000
S20-S29 Injuries to the thorax
0.957 0.043 0.000
M50 Cervical disk disorders
0.955 0.045 0.000
M47.2 Other spondylosis with radiculopathy
0.953 0.047 0.000
S40 Superficial injury of shoulder and upper arm
0.948 0.052 0.000
M47.9 Spondylosis, unspecified
0.948 0.052 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.944 0.056 0.000
S42 Fracture of shoulder and upper arm
0.942 0.058 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.939 0.061 0.000
M48 Other spondylopathies
0.935 0.065 0.000
M25 Other joint disorders, not elsewhere classified
0.934 0.066 0.000
S06 Intracranial injury
0.934 0.066 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.931 0.069 0.000
M24 Other specific joint derangements
0.931 0.069 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.928 0.072 0.000
W00-W19 Falls
0.926 0.074 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.921 0.079 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.913 0.087 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.912 0.088 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.907 0.093 0.000
M70-M79 Other soft tissue disorders
0.906 0.094 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.895 0.105 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.892 0.108 0.000
S20 Superficial injury of thorax
0.890 0.110 0.000
M54.55 Low back pain (Thoracolumbar region)
0.883 0.117 0.000
M47.8 Other spondylosis
0.882 0.118 0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)
0.881 0.119 0.000
M65-M68 Disorders of synovium and tendon
0.880 0.120 0.000
M54.56 Low back pain (Lumbar region)
0.879 0.121 0.000
M40-M43 Deforming dorsopathies
0.877 0.123 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.877 0.123 0.000
S05 Injury of eye and orbit
0.875 0.125 0.000
M48.0 Spinal stenosis
0.875 0.125 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.866 0.134 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.865 0.135 0.000
M91-M94 Chondropathies
0.865 0.135 0.000
M50.3 Other cervical disk degeneration
0.864 0.136 0.000
M47.82 Other spondylosis (Cervical region)
0.864 0.136 0.000
R25 Abnormal involuntary movements
0.860 0.140 0.000
M54.3 Sciatica
0.858 0.142 0.000
G90-G99 Other disorders of the nervous system
0.857 0.143 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.856 0.144 0.000
S42.0 Fracture of clavicle
0.856 0.144 0.000
S40.9 Superficial injury of shoulder and upper arm, unspecified
0.853 0.147 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.852 0.148 0.000
S40.0 Contusion of shoulder and upper arm
0.852 0.148 0.000
S02 Fracture of skull and facial bones
0.851 0.149 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.849 0.151 0.000
Chapter IX Diseases of the circulatory system
0.847 0.153 0.000
M54.9 Dorsalgia, unspecified
0.847 0.153 0.000
M34 Systemic sclerosis
0.847 0.153 0.000
R94 Abnormal results of function studies
0.838 0.162 0.000
W19 Unspecified fall
0.837 0.163 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.831 0.169 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.831 0.169 0.000
S42.3 Fracture of shaft of humerus
0.829 0.171 0.000
M50.2 Other cervical disk displacement
0.828 0.172 0.000
M25.8 Other specified joint disorders
0.827 0.173 0.000
M51 Other intervertebral disk disorders
0.826 0.174 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.825 0.175 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.817 0.183 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.817 0.183 0.000
T79-T79 Certain early complications of trauma
0.816 0.184 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.815 0.185 0.000
S06.5 Traumatic subdural haemorrhage
0.814 0.186 0.000
Chapter V Mental and behavioural disorders
0.813 0.187 0.000
M25.5 Pain in joint
0.813 0.187 0.000
M54.59 Low back pain (Site unspecified)
0.811 0.189 0.000
R47-R49 Symptoms and signs involving speech and voice
0.811 0.189 0.000
M45 Ankylosing spondylitis
0.810 0.190 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.808 0.192 0.000
V20-V29 Motorcycle rider injured in transport accident
0.808 0.192 0.000
G57 Mononeuropathies of lower limb
0.807 0.193 0.000
X20-X29 Contact with venomous animals and plants
0.806 0.194 0.000
M80-M85 Disorders of bone density and structure
0.804 0.196 0.000
I60-I69 Cerebrovascular diseases
0.804 0.196 0.000
M53 Other dorsopathies, not elsewhere classified
0.802 0.198 0.000
M54.6 Pain in thoracic spine
0.802 0.198 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.799 0.201 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.797 0.203 0.000
S06.8 Other intracranial injuries
0.796 0.204 0.000
M24.2 Disorder of ligament
0.796 0.204 0.000
W20-W49 Exposure to inanimate mechanical forces
0.794 0.206 0.000
S10-S19 Injuries to the neck
0.794 0.206 0.000
V80-V89 Other land transport accidents
0.794 0.206 0.000
S42.00 Fracture of clavicle (closed)
0.793 0.207 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.791 0.209 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.791 0.209 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.790 0.210 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.789 0.211 0.000
M24.5 Contracture of joint
0.789 0.211 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.786 0.214 0.000
M54.4 Lumbago with sciatica
0.786 0.214 0.000
M22 Disorders of patella
0.786 0.214 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.783 0.217 0.000
M25.56 Pain in joint (Lower leg)
0.781 0.219 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.778 0.222 0.000
M47.22 Other spondylosis with radiculopathy (Cervical region)
0.777 0.223 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.777 0.223 0.000
M94 Other disorders of cartilage
0.776 0.224 0.000
F41 Other anxiety disorders
0.775 0.225 0.000
S06.2 Diffuse brain injury
0.775 0.225 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.774 0.226 0.000
M47.94 Spondylosis, unspecified (Thoracic region)
0.773 0.227 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.773 0.227 0.000
M24.1 Other articular cartilage disorders
0.770 0.230 0.000
S20.8 Superficial injuries of other and unspecified parts of thorax
0.770 0.230 0.000
X50-X57 Overexertion, travel and privation
0.769 0.231 0.000
Y45.1 Salicylates
0.769 0.231 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.766 0.234 0.000
W19.9 Unspecified place
0.766 0.234 0.000
R25.2 Cramp and spasm
0.765 0.235 0.000
M25.3 Other instability of joint
0.764 0.235 0.000
F41.9 Anxiety disorder, unspecified
0.763 0.237 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.763 0.237 0.000
M48.02 Spinal stenosis (Cervical region)
0.761 0.239 0.000
W50-W64 Exposure to animate mechanical forces
0.760 0.240 0.000
W13 Fall from, out of or through building or structure
0.759 0.240 0.000
M49 Spondylopathies in diseases classified elsewhere
0.759 0.241 0.000
R94.5 Abnormal results of liver function studies
0.757 0.243 0.000
S42.1 Fracture of scapula
0.757 0.243 0.000
Chapter XXII Codes for special purposes
0.756 0.244 0.000
I69 Sequelae of cerebrovascular disease
0.754 0.246 0.000
R27 Other lack of coordination
0.754 0.246 0.000
M50.1 Cervical disk disorder with radiculopathy
0.752 0.248 0.000
G96 Other disorders of central nervous system
0.752 0.248 0.000
Chapter X Diseases of the respiratory system
0.752 0.248 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.751 0.248 0.000
Chapter VIII Diseases of the ear and mastoid process
0.750 0.249 0.000
M47.1 Other spondylosis with myelopathy
0.749 0.251 0.000
S42.30 Fracture of shaft of humerus (closed)
0.747 0.253 0.000
R47 Speech disturbances, not elsewhere classified
0.747 0.253 0.000
Y00-Y09 Assault
0.745 0.255 0.000
S46.0 Injury of tendon of the rotator cuff of shoulder
0.744 0.256 0.000
M54.50 Low back pain (Multiple sites in spine)
0.743 0.257 0.000
M30 Polyarteritis nodosa and related conditions
0.742 0.258 0.000
R94.3 Abnormal results of cardiovascular function studies
0.742 0.258 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.738 0.262 0.000
S20.3 Other superficial injuries of front wall of thorax
0.737 0.263 0.000
V10-V19 Pedal cyclist injured in transport accident
0.737 0.263 0.000
M79.1 Myalgia
0.737 0.263 0.000
W10 Fall on and from stairs and steps
0.736 0.264 0.000
R29.6 Tendency to fall, not elsewhere classified
0.736 0.264 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.736 0.264 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.735 0.265 0.000
J30-J39 Other diseases of upper respiratory tract
0.735 0.265 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.734 0.266 0.000
M34.9 Systemic sclerosis, unspecified
0.733 0.267 0.000
Y44 Agents primarily affecting blood constituents
0.732 0.268 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.732 0.268 0.000
G12 Spinal muscular atrophy and related syndromes
0.732 0.268 0.000
M21 Other acquired deformities of limbs
0.731 0.269 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.729 0.271 0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)
0.729 0.271 0.000
M60-M63 Disorders of muscles
0.728 0.271 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.728 0.272 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.728 0.272 0.000
M67 Other disorders of synovium and tendon
0.727 0.273 0.000
Y52 Agents primarily affecting the cardiovascular system
0.727 0.273 0.000
S20.2 Contusion of thorax
0.726 0.274 0.000
J34 Other disorders of nose and nasal sinuses
0.726 0.274 0.000
S02.4 Fracture of malar and maxillary bones
0.725 0.275 0.000
R44.1 Visual hallucinations
0.725 0.275 0.000
F80-F89 Disorders of psychological development
0.724 0.276 0.000
R45 Symptoms and signs involving emotional state
0.724 0.276 0.000
M43 Other deforming dorsopathies
0.724 0.276 0.000
M00-M03 Infectious arthropathies
0.723 0.277 0.000
M72 Fibroblastic disorders
0.723 0.277 0.000
G40-G47 Episodic and paroxysmal disorders
0.722 0.278 0.000
S22.4 Multiple fractures of ribs
0.722 0.278 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.721 0.279 0.000
M54.39 Sciatica (Site unspecified)
0.721 0.279 0.000
M65 Synovitis and tenosynovitis
0.720 0.280 0.000
S05.9 Injury of eye and orbit, part unspecified
0.720 0.280 0.000
M25.0 Haemarthrosis
0.720 0.280 0.000
J34.2 Deviated nasal septum
0.719 0.281 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
X60-X84 Intentional self-harm
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I95 Hypotension
0.717 0.283 0.000
S08 Traumatic amputation of part of head
0.716 0.284 0.000
S07 Crushing injury of head
0.716 0.284 0.000
S04 Injury of cranial nerves
0.716 0.284 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.716 0.284 0.000
W08 Fall involving other furniture
0.716 0.284 0.000
S09.8 Other specified injuries of head
0.714 0.286 0.000
S09.7 Multiple injuries of head
0.714 0.286 0.000
S09.2 Traumatic rupture of ear drum
0.714 0.286 0.000
S09.1 Injury of muscle and tendon of head
0.714 0.286 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.714 0.286 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.714 0.286 0.000
S48 Traumatic amputation of shoulder and upper arm
0.713 0.286 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.713 0.286 0.000
S44 Injury of nerves at shoulder and upper arm level
0.713 0.286 0.000
S41 Open wound of shoulder and upper arm
0.713 0.286 0.000
S47 Crushing injury of shoulder and upper arm
0.713 0.286 0.000
R40 Somnolence, stupor and coma
0.713 0.287 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.713 0.287 0.000
R25.3 Fasciculation
0.713 0.287 0.000
M54.1 Radiculopathy
0.713 0.287 0.000
S30.1 Contusion of abdominal wall
0.713 0.287 0.000
Q80-Q89 Other congenital malformations
0.712 0.288 0.000
M41 Scoliosis
0.712 0.288 0.000
M54.8 Other dorsalgia
0.712 0.288 0.000
M54.0 Panniculitis affecting regions of neck and back
0.712 0.288 0.000
R90.0 Intracranial space-occupying lesion
0.711 0.289 0.000
Y35-Y36 Legal intervention and operations of war
0.711 0.289 0.000
Y10-Y34 Event of undetermined intent
0.711 0.289 0.000
X85-X99 Assault
0.711 0.289 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.711 0.289 0.000
X30-X39 Exposure to forces of nature
0.711 0.289 0.000
X10-X19 Contact with heat and hot substances
0.711 0.289 0.000
X00-X09 Exposure to smoke, fire and flames
0.711 0.289 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.711 0.289 0.000
W75-W84 Other accidental threats to breathing
0.711 0.289 0.000
W65-W74 Accidental drowning and submersion
0.711 0.289 0.000
V98-V99 Other and unspecified transport accidents
0.711 0.289 0.000
V95-V97 Air and space transport accidents
0.711 0.289 0.000
V90-V94 Water transport accidents
0.711 0.289 0.000
V70-V79 Bus occupant injured in transport accident
0.711 0.289 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.711 0.289 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.711 0.289 0.000
V40-V49 Car occupant injured in transport accident
0.711 0.289 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.711 0.289 0.000
V01-V09 Pedestrian injured in transport accident
0.711 0.289 0.000
S29 Other and unspecified injuries of thorax
0.710 0.290 0.000
S31 Open wound of abdomen, lower back and pelvis
0.709 0.291 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.708 0.292 0.000
S50-S59 Injuries to the elbow and forearm
0.707 0.293 0.000
W18 Other fall on same level
0.704 0.296 0.000
M48.09 Spinal stenosis (Site unspecified)
0.704 0.296 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.704 0.296 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.702 0.298 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.700 0.300 0.000
S06.80 Other intracranial injuries (without open intracranial wound)
0.698 0.302 0.000
Y40 Systemic antibiotics
0.697 0.303 0.000
T66-T78 Other and unspecified effects of external causes
0.696 0.304 0.000
L57 Skin changes due to chronic exposure to nonionising radiation
0.696 0.304 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.695 0.305 0.000
M33 Dermatopolymyositis
0.695 0.305 0.000
M32 Systemic lupus erythematosus
0.695 0.305 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.694 0.306 0.000
M54.54 Low back pain-Thoracic
0.694 0.306 0.000
M54.53 Low back pain-Cervicothoracic
0.694 0.306 0.000
M54.52 Low back pain-Cervical
0.694 0.306 0.000
M54.51 Low back pain-Occipit-atl-axl
0.694 0.306 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.694 0.306 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.692 0.308 0.000
M05-M14 Inflammatory polyarthropathies
0.692 0.308 0.000
H80-H83 Diseases of inner ear
0.692 0.308 0.000
S05.8 Other injuries of eye and orbit
0.692 0.308 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.691 0.309 0.000
M22.4 Chondromalacia patellae
0.691 0.309 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.689 0.311 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.686 0.314 0.000
S26 Injury of heart
0.686 0.314 0.000
S25 Injury of blood vessels of thorax
0.686 0.314 0.000
S24 Injury of nerves and spinal cord at thorax level
0.686 0.314 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.686 0.314 0.000
S21 Open wound of thorax
0.686 0.314 0.000
R25.8 Other and unspecified abnormal involuntary movements
0.686 0.314 0.000
Y45.5 4-Aminophenol derivatives
0.685 0.315 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.685 0.315 0.000
S05.1 Contusion of eyeball and orbital tissues
0.685 0.315 0.000
M50.9 Cervical disk disorder, unspecified
0.685 0.315 0.000
M50.8 Other cervical disk disorders
0.685 0.315 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.684 0.316 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.684 0.316 0.000
M50.0 Cervical disk disorder with myelopathy
0.683 0.317 0.000
M47.29 Other spondylosis with radiculopathy (Site unspecified)
0.683 0.317 0.000
M47.28 Other spondylosis with radiculopathy (Sacral and sacrococcygeal region)
0.683 0.317 0.000
M47.25 Other spondylosis with radiculopathy (Thoracolumbar region)
0.683 0.317 0.000
M47.24 Other spondylosis with radiculopathy (Thoracic region)
0.683 0.317 0.000
M47.23 Other spondylosis with radiculopathy (Cervicothoracic region)
0.683 0.317 0.000
M47.21 Other spondylosis with radiculopathy (Occipito-atlanto-axial region)
0.683 0.317 0.000
M47.20 Other spondylosis with radiculopathy (Multiple sites in spine)
0.683 0.317 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.682 0.318 0.000
I62 Other nontraumatic intracranial haemorrhage
0.682 0.318 0.000
M54.36 Sciatica (Lumbar region)
0.682 0.318 0.000
M25.86 Other specified joint disorders (Lower leg)
0.680 0.320 0.000
S40.8 Other superficial injuries of shoulder and upper arm
0.679 0.320 0.000
S40.7 Multiple superficial injuries of shoulder and upper arm
0.679 0.320 0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)
0.679 0.321 0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)
0.679 0.321 0.000
M47.93 Spondylosis, unspecified (Cervicothoracic region)
0.679 0.321 0.000
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)
0.679 0.321 0.000
M24.24 Disorder of ligament (Hand)
0.679 0.321 0.000
I95.1 Orthostatic hypotension
0.678 0.322 0.000
M46 Other inflammatory spondylopathies
0.678 0.322 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.678 0.322 0.000
S42.9 Fracture of shoulder girdle, part unspecified
0.677 0.322 0.000
Y59 Other and unspecified vaccines and biological substances
0.677 0.323 0.000
Y58 Bacterial vaccines
0.677 0.323 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.677 0.323 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.677 0.323 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.677 0.323 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.677 0.323 0.000
Y48 Anaesthetics and therapeutic gases
0.677 0.323 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.677 0.323 0.000
L60-L75 Disorders of skin appendages
0.677 0.323 0.000
F41.2 Mixed anxiety and depressive disorder
0.677 0.323 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.676 0.324 0.000
S42.8 Fracture of other parts of shoulder and upper arm
0.676 0.324 0.000
S42.7 Multiple fractures of clavicle, scapula and humerus
0.676 0.324 0.000
M24.0 Loose body in joint
0.676 0.324 0.000
M54.57 Low back pain (Lumbosacral region)
0.675 0.325 0.000
S43.1 Dislocation of acromioclavicular joint
0.674 0.326 0.000
S22.3 Fracture of rib
0.673 0.326 0.000
G52 Disorders of other cranial nerves
0.673 0.327 0.000
X23 Contact with hornets, wasps and bees
0.673 0.327 0.000
T17 Foreign body in respiratory tract
0.672 0.328 0.000
S27 Injury of other and unspecified intrathoracic organs
0.671 0.329 0.000
M48.9 Spondylopathy, unspecified
0.671 0.329 0.000
M48.8 Other specified spondylopathies
0.671 0.329 0.000
M48.4 Fatigue fracture of vertebra
0.671 0.329 0.000
M48.3 Traumatic spondylopathy
0.671 0.329 0.000
M48.2 Kissing spine
0.671 0.329 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.671 0.329 0.000
S70-S79 Injuries to the hip and thigh
0.671 0.329 0.000
R47.8 Other and unspecified speech disturbances
0.670 0.330 0.000
M25.9 Joint disorder, unspecified
0.670 0.330 0.000
M25.2 Flail joint
0.670 0.330 0.000
M25.1 Fistula of joint
0.670 0.330 0.000
S06.9 Intracranial injury, unspecified
0.669 0.330 0.000
S06.7 Intracranial injury with prolonged coma
0.669 0.330 0.000
S06.4 Epidural haemorrhage
0.669 0.330 0.000
S06.1 Traumatic cerebral oedema
0.669 0.330 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.670 0.330 0.000
M94.8 Other specified disorders of cartilage
0.668 0.332 0.000
I99 Other and unspecified disorders of circulatory system
0.668 0.332 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.667 0.332 0.000
M24.9 Joint derangement, unspecified
0.667 0.332 0.000
M24.7 Protrusio acetabuli
0.667 0.332 0.000
M24.6 Ankylosis of joint
0.667 0.332 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.667 0.332 0.000
S90-S99 Injuries to the ankle and foot
0.667 0.333 0.000
S02.3 Fracture of orbital floor
0.666 0.333 0.000
M84 Disorders of continuity of bone
0.666 0.333 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.665 0.335 0.000
M25.53 Pain in joint (Forearm)
0.665 0.335 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.665 0.335 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.664 0.335 0.000
I60 Subarachnoid haemorrhage
0.664 0.335 0.000
W17 Other fall from one level to another
0.664 0.336 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.664 0.336 0.000
W15 Fall from cliff
0.664 0.336 0.000
W14 Fall from tree
0.664 0.336 0.000
W12 Fall on and from scaffolding
0.664 0.336 0.000
W11 Fall on and from ladder
0.664 0.336 0.000
W09 Fall involving playground equipment
0.664 0.336 0.000
W05 Fall involving wheelchair
0.664 0.336 0.000
W04 Fall while being carried or supported by other persons
0.664 0.336 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.664 0.336 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.664 0.336 0.000
W00 Fall on same level involving ice and snow
0.664 0.336 0.000
I05-I09 Chronic rheumatic heart diseases
0.664 0.336 0.000
R46 Symptoms and signs involving appearance and behaviour
0.662 0.337 0.000
G57.8 Other mononeuropathies of lower limb
0.662 0.338 0.000
M34.8 Other forms of systemic sclerosis
0.662 0.338 0.000
L57.0 Actinic keratosis
0.661 0.339 0.000
G93 Other disorders of brain
0.661 0.339 0.000
S06.20 Diffuse brain injury (without open intracranial wound)
0.661 0.339 0.000
M40 Kyphosis and lordosis
0.660 0.339 0.000
M66 Spontaneous rupture of synovium and tendon
0.660 0.339 0.000
G12.2 Motor neuron disease
0.660 0.340 0.000
M71 Other bursopathies
0.660 0.340 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.660 0.340 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.660 0.340 0.000
Y57 Other and unspecified drugs and medicaments
0.660 0.340 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.659 0.341 0.000
M48.06 Spinal stenosis (Lumbar region)
0.659 0.341 0.000
G90 Disorders of autonomic nervous system
0.658 0.342 0.000
S02.6 Fracture of mandible
0.657 0.343 0.000
S06.3 Focal brain injury
0.656 0.344 0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis
0.656 0.344 0.000
R47.0 Dysphasia and aphasia
0.655 0.345 0.000
S80-S89 Injuries to the knee and lower leg
0.654 0.346 0.000
S02.1 Fracture of base of skull
0.654 0.346 0.000
S42.4 Fracture of lower end of humerus
0.654 0.346 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.654 0.346 0.000
S37 Injury of urinary and pelvic organs
0.654 0.346 0.000
S36 Injury of intra-abdominal organs
0.654 0.346 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.654 0.346 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.654 0.346 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.654 0.346 0.000
G70-G73 Diseases of myoneural junction and muscle
0.653 0.347 0.000
R40.2 Coma, unspecified
0.653 0.347 0.000
G96.0 Cerebrospinal fluid leak
0.652 0.348 0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.652 0.348 0.000
V80 Animal-rider or occupant of animal-drawn vehicle injured in transport accident
0.651 0.349 0.000
I77 Other disorders of arteries and arterioles
0.650 0.350 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.649 0.350 0.000
M75 Shoulder lesions
0.650 0.350 0.000
M24.57 Contracture of joint (Ankle and foot)
0.649 0.351 0.000
M47.89 Other spondylosis (Site unspecified)
0.649 0.351 0.000
W19.1 Residential institution
0.648 0.352 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.648 0.352 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.648 0.352 0.000
S22.40 Multiple fractures of ribs (closed)
0.647 0.353 0.000
M94.2 Chondromalacia
0.647 0.353 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.646 0.353 0.000
M76 Enthesopathies of lower limb, excluding foot
0.645 0.355 0.000
W19.4 Street and highway
0.644 0.356 0.000
M25.4 Effusion of joint
0.644 0.356 0.000
M79.10 Myalgia (Multiple sites)
0.644 0.356 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.643 0.357 0.000
M25.37 Other instability of joint (Ankle and foot)
0.643 0.357 0.000
R29.4 Clicking hip
0.642 0.358 0.000
R29.3 Abnormal posture
0.642 0.358 0.000
R29.2 Abnormal reflex
0.642 0.358 0.000
R29.1 Meningismus
0.642 0.358 0.000
R29.0 Tetany
0.642 0.358 0.000
S19 Other and unspecified injuries of neck
0.642 0.358 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.641 0.358 0.000
H83 Other diseases of inner ear
0.641 0.359 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.641 0.359 0.000
W13.9 Unspecified place
0.640 0.360 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.639 0.361 0.000
S20.7 Multiple superficial injuries of thorax
0.638 0.362 0.000
S20.4 Other superficial injuries of back wall of thorax
0.638 0.362 0.000
S20.1 Other and unspecified superficial injuries of breast
0.638 0.362 0.000
S20.0 Contusion of breast
0.638 0.362 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.637 0.362 0.000
G50 Disorders of trigeminal nerve
0.636 0.364 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.636 0.364 0.000
W06 Fall involving bed
0.634 0.366 0.000
W44 Foreign body entering into or through eye or natural orifice
0.634 0.366 0.000
M70.6 Trochanteric bursitis
0.634 0.366 0.000
G57.6 Lesion of plantar nerve
0.634 0.366 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.633 0.367 0.000
S02.0 Fracture of vault of skull
0.633 0.367 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.632 0.368 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.632 0.368 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.632 0.368 0.000
M47.84 Other spondylosis (Thoracic region)
0.632 0.368 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.632 0.368 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.632 0.368 0.000
M21.2 Flexion deformity
0.632 0.368 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.632 0.368 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.631 0.369 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.631 0.369 0.000
J34.3 Hypertrophy of nasal turbinates
0.631 0.369 0.000
M79.11 Myalgia (Shoulder region)
0.630 0.369 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.630 0.370 0.000
M42 Spinal osteochondrosis
0.629 0.371 0.000
Q00-Q07 Congenital malformations of the nervous system
0.628 0.372 0.000
S05.7 Avulsion of eye
0.628 0.372 0.000
S05.6 Penetrating wound of eyeball without foreign body
0.628 0.372 0.000
S05.5 Penetrating wound of eyeball with foreign body
0.628 0.372 0.000
S05.4 Penetrating wound of orbit with or without foreign body
0.628 0.372 0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue
0.628 0.372 0.000
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue
0.628 0.372 0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body
0.628 0.372 0.000
F81 Specific developmental disorders of scholastic skills
0.628 0.372 0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.627 0.372 0.000
M48.05 Spinal stenosis (Thoracolumbar region)
0.627 0.372 0.000
M48.04 Spinal stenosis (Thoracic region)
0.627 0.372 0.000
M48.03 Spinal stenosis (Cervicothoracic region)
0.627 0.372 0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)
0.627 0.372 0.000
M25.52 Pain in joint (Upper arm)
0.627 0.373 0.000
M24.56 Contracture of joint (Lower leg)
0.627 0.373 0.000
H60-H62 Diseases of external ear
0.627 0.373 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.626 0.374 0.000
M70.5 Other bursitis of knee
0.626 0.374 0.000
M25.81 Other specified joint disorders (Shoulder region)
0.625 0.375 0.000
G91 Hydrocephalus
0.625 0.375 0.000
M51.9 Intervertebral disk disorder, unspecified
0.625 0.375 0.000
M54.37 Sciatica (Lumbosacral region)
0.624 0.376 0.000
M25.87 Other specified joint disorders (Ankle and foot)
0.624 0.376 0.000
S42.10 Fracture of scapula (closed)
0.624 0.376 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.624 0.376 0.000
G00 Bacterial meningitis, not elsewhere classified
0.623 0.377 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.623 0.377 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.622 0.378 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.621 0.379 0.000
X50 Overexertion and strenuous or repetitive movements
0.621 0.379 0.000
W22 Striking against or struck by other objects
0.621 0.379 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.621 0.379 0.000
Y45.8 Other analgesics and antipyretics
0.621 0.379 0.000
Y45.4 Antirheumatics
0.621 0.379 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.620 0.379 0.000
R45.1 Restlessness and agitation
0.620 0.379 0.000
M92 Other juvenile osteochondrosis
0.620 0.380 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.620 0.380 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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