TreeWAS – Variant ID: rs74378727

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	1.000	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	1.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
I30-I52 Other forms of heart disease	0.999	0.001
R50-R69 General symptoms and signs	0.998	0.002
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.997	0.003
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.994	0.006
Chapter XII Diseases of the skin and subcutaneous tissue	0.994	0.006
Chapter XX External causes of morbidity and mortality	0.994	0.006
R55 Syncope and collapse	0.991	0.009
Chapter VI Diseases of the nervous system	0.989	0.011
L80-L99 Other disorders of the skin and subcutaneous tissue	0.988	0.012
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.978	0.022
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.976	0.024
I50 Heart failure	0.968	0.032
M70-M79 Other soft tissue disorders	0.967	0.033
M20-M25 Other joint disorders	0.966	0.034
Chapter IV Endocrine, nutritional and metabolic diseases	0.957	0.043
R00 Abnormalities of heart beat	0.954	0.046
L82 Seborrhoeic keratosis	0.952	0.048
R00.1 Bradycardia, unspecified	0.949	0.051
M25 Other joint disorders, not elsewhere classified	0.939	0.061
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.930	0.070
R42 Dizziness and giddiness	0.928	0.072
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.927	0.073
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.926	0.074
E10-E14 Diabetes mellitus	0.926	0.074
S60-S69 Injuries to the wrist and hand	0.923	0.077
T36-T50 Poisoning by drugs, medicaments and biological substances	0.920	0.080
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.920	0.080
I34 Nonrheumatic mitral valve disorders	0.917	0.082
R50 Fever of unknown origin	0.913	0.087
M25.5 Pain in joint	0.910	0.090
M79 Other soft tissue disorders, not elsewhere classified	0.910	0.090
L97 Ulcer of lower limb, not elsewhere classified	0.909	0.091
I70-I79 Diseases of arteries, arterioles and capillaries	0.907	0.093
I49 Other cardiac arrhythmias	0.906	0.094
Chapter XV Pregnancy, childbirth and the puerperium	0.901	0.099
T81 Complications of procedures, not elsewhere classified	0.895	0.105
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.887	0.113
G90-G99 Other disorders of the nervous system	0.887	0.113
I50.1 Left ventricular failure	0.886	0.114
Y86 Sequelae of other accidents	0.883	0.117
G40-G47 Episodic and paroxysmal disorders	0.882	0.118
I95-I99 Other and unspecified disorders of the circulatory system	0.880	0.120
I34.0 Mitral (valve) insufficiency	0.878	0.122
I50.0 Congestive heart failure	0.878	0.122
Chapter V Mental and behavioural disorders	0.875	0.125
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.872	0.128
Chapter VII Diseases of the eye and adnexa	0.872	0.128
I31 Other diseases of pericardium	0.872	0.128
R07 Pain in throat and chest	0.866	0.134
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.866	0.134
L50-L54 Urticaria and erythema	0.863	0.137
E20-E35 Disorders of other endocrine glands	0.862	0.138
S40-S49 Injuries to the shoulder and upper arm	0.859	0.141
M75 Shoulder lesions	0.856	0.144
R41 Other symptoms and signs involving cognitive functions and awareness	0.856	0.144
T81.8 Other complications of procedures, not elsewhere classified	0.855	0.145
M25.57 Pain in joint (Ankle and foot)	0.852	0.148
R59 Enlarged lymph nodes	0.852	0.148
O60-O75 Complications of labour and delivery	0.847	0.153
Chapter XXI Factors influencing health status and contact with health services	0.846	0.154
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.844	0.156
I42 Cardiomyopathy	0.843	0.157
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.842	0.158
Chapter VIII Diseases of the ear and mastoid process	0.840	0.160
M79.8 Other specified soft tissue disorders	0.836	0.164
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.833	0.167
M25.55 Pain in joint (Pelvic region and thigh)	0.830	0.170
E50-E64 Other nutritional deficiencies	0.830	0.170
R63 Symptoms and signs concerning food and fluid intake	0.828	0.172
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.826	0.174
Chapter II Neoplasms	0.826	0.174
R50.9 Fever, unspecified	0.825	0.175
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.824	0.176
R07.4 Chest pain, unspecified	0.824	0.176
M20 Acquired deformities of fingers and toes	0.821	0.179
I47 Paroxysmal tachycardia	0.820	0.180
M40-M43 Deforming dorsopathies	0.818	0.182
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.814	0.186
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.812	0.188
E11 Non-insulin-dependent diabetes mellitus	0.812	0.188
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.812	0.188
I20-I25 Ischaemic heart diseases	0.811	0.189
M22 Disorders of patella	0.810	0.190
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status	0.808	0.192
Z80 Family history of malignant neoplasm	0.808	0.192
R56 Convulsions, not elsewhere classified	0.805	0.195
I73 Other peripheral vascular diseases	0.804	0.196
E14 Unspecified diabetes mellitus	0.800	0.200
G30-G32 Other degenerative diseases of the nervous system	0.798	0.202
G80-G83 Cerebral palsy and other paralytic syndromes	0.797	0.203
T85 Complications of other internal prosthetic devices, implants and grafts	0.796	0.204
L90 Atrophic disorders of skin	0.796	0.204
V10-V19 Pedal cyclist injured in transport accident	0.795	0.205
E10 Insulin-dependent diabetes mellitus	0.793	0.207
R03 Abnormal blood-pressure reading, without diagnosis	0.792	0.208
T80 Complications following infusion, transfusion and therapeutic injection	0.792	0.208
S64 Injury of nerves at wrist and hand level	0.792	0.208
D00-D09 In situ neoplasms	0.791	0.209
R21 Rash and other nonspecific skin eruption	0.790	0.210
F00-F09 Organic, including symptomatic, mental disorders	0.789	0.211
Z80.0 Family history of malignant neoplasm of digestive organs	0.789	0.211
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.788	0.212
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.788	0.212
M45-M49 Spondylopathies	0.787	0.213
M05-M14 Inflammatory polyarthropathies	0.786	0.214
R02 Gangrene, not elsewhere classified	0.784	0.216
G93 Other disorders of brain	0.784	0.216
Chapter X Diseases of the respiratory system	0.784	0.216
L89 Decubitus ulcer	0.783	0.217
R41.0 Disorientation, unspecified	0.782	0.218
I33 Acute and subacute endocarditis	0.781	0.219
L93 Lupus erythematosus	0.781	0.219
I49.3 Ventricular premature depolarisation	0.780	0.220
Chapter XI Diseases of the digestive system	0.778	0.222
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.777	0.223
T66-T78 Other and unspecified effects of external causes	0.777	0.223
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.777	0.223
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.776	0.224
S66 Injury of muscle and tendon at wrist and hand level	0.775	0.225
Y95 Nosocomial condition	0.774	0.226
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.774	0.226
I51 Complications and ill-defined descriptions of heart disease	0.773	0.227
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.772	0.228
G00-G09 Inflammatory diseases of the central nervous system	0.770	0.230
H04 Disorders of lachrymal system	0.769	0.231
W20-W49 Exposure to inanimate mechanical forces	0.769	0.231
M25.6 Stiffness of joint, not elsewhere classified	0.766	0.234
S42 Fracture of shoulder and upper arm	0.766	0.234
I95 Hypotension	0.766	0.234
O72 Postpartum haemorrhage	0.765	0.235
L92 Granulomatous disorders of skin and subcutaneous tissue	0.762	0.237
R59.0 Localised enlarged lymph nodes	0.762	0.238
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.762	0.238
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.759	0.240
M77 Other enthesopathies	0.758	0.242
H02 Other disorders of eyelid	0.757	0.243
S20-S29 Injuries to the thorax	0.756	0.244
X40-X49 Accidental poisoning by and exposure to noxious substances	0.756	0.244
M79.86 Other specified soft tissue disorders (Lower leg)	0.754	0.246
G40 Epilepsy	0.752	0.248
G91 Hydrocephalus	0.751	0.249
M86-M90 Other osteopathies	0.749	0.251
I31.9 Disease of pericardium, unspecified	0.746	0.254
I50.9 Heart failure, unspecified	0.746	0.254
M75.4 Impingement syndrome of shoulder	0.745	0.255
L85 Other epidermal thickening	0.745	0.255
T88 Other complications of surgical and medical care, not elsewhere classified	0.744	0.256
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.743	0.257
M80-M85 Disorders of bone density and structure	0.742	0.258
I38 Endocarditis, valve unspecified	0.735	0.265
R44 Other symptoms and signs involving general sensations and perceptions	0.735	0.265
Chapter XIV Diseases of the genitourinary system	0.734	0.266
M79.0 Rheumatism, unspecified	0.734	0.266
M65-M68 Disorders of synovium and tendon	0.730	0.270
R51 Headache	0.729	0.271
L40-L45 Papulosquamous disorders	0.729	0.271
K13 Other diseases of lip and oral mucosa	0.729	0.271
I47.2 Ventricular tachycardia	0.729	0.271
I49.1 Atrial premature depolarisation	0.728	0.271
G45 Transient cerebral ischaemic attacks and related syndromes	0.728	0.272
I45 Other conduction disorders	0.727	0.272
L50 Urticaria	0.727	0.273
G62 Other polyneuropathies	0.726	0.274
L20-L30 Dermatitis and eczema	0.726	0.274
G35-G37 Demyelinating diseases of the central nervous system	0.726	0.274
T83.3 Mechanical complication of intra-uterine contraceptive device	0.725	0.275
D05 Carcinoma in situ of breast	0.725	0.275
T83.0 Mechanical complication of urinary (indwelling) catheter	0.725	0.275
M20.1 Hallux valgus (acquired)	0.725	0.275
O63 Long labour	0.723	0.277
I74 Arterial embolism and thrombosis	0.723	0.277
T15-T19 Effects of foreign body entering through natural orifice	0.723	0.277
I26 Pulmonary embolism	0.722	0.278
L91 Hypertrophic disorders of skin	0.721	0.279
M35 Other systemic involvement of connective tissue	0.721	0.279
M79.1 Myalgia	0.721	0.279
R45 Symptoms and signs involving emotional state	0.720	0.280
R63.4 Abnormal weight loss	0.720	0.280
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.718	0.282
K14 Diseases of tongue	0.718	0.282
M50-M54 Other dorsopathies	0.717	0.283
S42.2 Fracture of upper end of humerus	0.717	0.283
Chapter XXII Codes for special purposes	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
R95-R99 Ill-defined and unknown causes of mortality	0.717	0.283
T79-T79 Certain early complications of trauma	0.717	0.283
T33-T35 Frostbite	0.717	0.283
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.717	0.283
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283
T20-T25 Burns and corrosions of external body surface, specified by site	0.717	0.283
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.717	0.283
T00-T07 Injuries involving multiple body regions	0.717	0.283
S90-S99 Injuries to the ankle and foot	0.717	0.283
S10-S19 Injuries to the neck	0.717	0.283
I00-I02 Acute rheumatic fever	0.717	0.283
R50.8 Other specified fever	0.716	0.284
I52 Other heart disorders in diseases classified elsewhere	0.716	0.284
I48 Atrial fibrillation and flutter	0.716	0.284
I43 Cardiomyopathy in diseases classified elsewhere	0.716	0.284
I41 Myocarditis in diseases classified elsewhere	0.716	0.284
I40 Acute myocarditis	0.716	0.284
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.716	0.284
I37 Pulmonary valve disorders	0.716	0.284
I36 Nonrheumatic tricuspid valve disorders	0.716	0.284
I32 Pericarditis in diseases classified elsewhere	0.716	0.284
I30 Acute pericarditis	0.716	0.284
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.716	0.284
E55 Vitamin D deficiency	0.716	0.284
R68 Other general symptoms and signs	0.716	0.284
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.716	0.284
R62 Lack of expected normal physiological development	0.716	0.284
R57 Shock, not elsewhere classified	0.716	0.284
R64 Cachexia	0.716	0.284
R58 Haemorrhage, not elsewhere classified	0.716	0.284
R07.0 Pain in throat	0.715	0.285
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.715	0.285
M91-M94 Chondropathies	0.715	0.285
M60-M63 Disorders of muscles	0.715	0.285
M00-M03 Infectious arthropathies	0.715	0.285
I46 Cardiac arrest	0.715	0.285
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.715	0.285
G50-G59 Nerve, nerve root and plexus disorders	0.714	0.286
M25.7 Osteophyte	0.714	0.286
M25.53 Pain in joint (Forearm)	0.713	0.287
H80-H83 Diseases of inner ear	0.713	0.287
T87 Complications peculiar to reattachment and amputation	0.713	0.287
T86 Failure and rejection of transplanted organs and tissues	0.713	0.287
L10-L14 Bullous disorders	0.713	0.287
R00.8 Other and unspecified abnormalities of heart beat	0.713	0.287
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.713	0.287
Y35-Y36 Legal intervention and operations of war	0.713	0.287
Y10-Y34 Event of undetermined intent	0.713	0.287
Y00-Y09 Assault	0.713	0.287
X85-X99 Assault	0.713	0.287
X60-X84 Intentional self-harm	0.713	0.287
X58-X59 Accidental exposure to other and unspecified factors	0.713	0.287
X50-X57 Overexertion, travel and privation	0.713	0.287
X30-X39 Exposure to forces of nature	0.713	0.287
X20-X29 Contact with venomous animals and plants	0.713	0.287
X10-X19 Contact with heat and hot substances	0.713	0.287
X00-X09 Exposure to smoke, fire and flames	0.713	0.287
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.713	0.287
W75-W84 Other accidental threats to breathing	0.713	0.287
W65-W74 Accidental drowning and submersion	0.713	0.287
W50-W64 Exposure to animate mechanical forces	0.713	0.287
V98-V99 Other and unspecified transport accidents	0.713	0.287
V95-V97 Air and space transport accidents	0.713	0.287
V90-V94 Water transport accidents	0.713	0.287
V80-V89 Other land transport accidents	0.713	0.287
V70-V79 Bus occupant injured in transport accident	0.713	0.287
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.713	0.287
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.713	0.287
V40-V49 Car occupant injured in transport accident	0.713	0.287
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.713	0.287
V20-V29 Motorcycle rider injured in transport accident	0.713	0.287
V01-V09 Pedestrian injured in transport accident	0.713	0.287
E14.9 Without complications	0.713	0.287
E13 Other specified diabetes mellitus	0.712	0.288
S50-S59 Injuries to the elbow and forearm	0.711	0.289
L84 Corns and callosities	0.711	0.289
R47-R49 Symptoms and signs involving speech and voice	0.710	0.290
I49.9 Cardiac arrhythmia, unspecified	0.710	0.290
G70-G73 Diseases of myoneural junction and muscle	0.709	0.291
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.709	0.291
S62 Fracture at wrist and hand level	0.709	0.291
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.708	0.292
L95 Vasculitis limited to skin, not elsewhere classified	0.708	0.292
L94 Other localised connective tissue disorders	0.708	0.292
L87 Transepidermal elimination disorders	0.708	0.292
L88 Pyoderma gangrenosum	0.708	0.292
L86 Keratoderma in diseases classified elsewhere	0.708	0.292
L83 Acanthosis nigricans	0.708	0.292
L80 Vitiligo	0.708	0.292
H60-H62 Diseases of external ear	0.707	0.293
E23 Hypofunction and other disorders of pituitary gland	0.706	0.293
I71 Aortic aneurysm and dissection	0.706	0.293
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.706	0.294
O72.1 Other immediate postpartum haemorrhage	0.705	0.295
I49.0 Ventricular fibrillation and flutter	0.704	0.296
I42.0 Dilated cardiomyopathy	0.703	0.297
C15-C26 Malignant neoplasms of digestive organs	0.703	0.297
N17-N19 Renal failure	0.703	0.297
J20-J22 Other acute lower respiratory infections	0.702	0.298
E11.4 With neurological complications	0.701	0.298
F80-F89 Disorders of psychological development	0.701	0.299
Z80.5 Family history of malignant neoplasm of urinary tract	0.701	0.299
R46 Symptoms and signs involving appearance and behaviour	0.700	0.300
R43 Disturbances of smell and taste	0.700	0.300
I25 Chronic ischaemic heart disease	0.698	0.302
S64.4 Injury of digital nerve of other finger	0.697	0.303
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.696	0.304
R54 Senility	0.696	0.304
R01 Cardiac murmurs and other cardiac sounds	0.696	0.304
E29 Testicular dysfunction	0.696	0.304
L53 Other erythematous conditions	0.695	0.305
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.695	0.305
L90.0 Lichen sclerosus et atrophicus	0.694	0.306
R52 Pain, not elsewhere classified	0.694	0.306
H02.6 Xanthelasma of eyelid	0.694	0.306
I99 Other and unspecified disorders of circulatory system	0.694	0.306
I31.3 Pericardial effusion (noninflammatory)	0.693	0.307
M76 Enthesopathies of lower limb, excluding foot	0.693	0.307
M73 Soft tissue disorders in diseases classified elsewhere	0.693	0.307
M71 Other bursopathies	0.693	0.307
M70 Soft tissue disorders related to use, overuse and pressure	0.693	0.307
S80-S89 Injuries to the knee and lower leg	0.693	0.307
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.693	0.307
M34 Systemic sclerosis	0.693	0.307
M33 Dermatopolymyositis	0.693	0.307
M32 Systemic lupus erythematosus	0.693	0.307
M30 Polyarteritis nodosa and related conditions	0.693	0.307
M21 Other acquired deformities of limbs	0.693	0.307
Y84.0 Cardiac catheterisation	0.692	0.308
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.692	0.308
O69 Labour and delivery complicated by umbilical cord complications	0.691	0.309
Z94 Transplanted organ and tissue status	0.691	0.309
R40 Somnolence, stupor and coma	0.690	0.310
H04.2 Epiphora	0.689	0.311
S00-S09 Injuries to the head	0.688	0.312
L00-L08 Infections of the skin and subcutaneous tissue	0.688	0.312
I73.9 Peripheral vascular disease, unspecified	0.688	0.312
S70-S79 Injuries to the hip and thigh	0.688	0.312
G47 Sleep disorders	0.687	0.312
R22.2 Localised swelling, mass and lump, trunk	0.687	0.313
I77 Other disorders of arteries and arterioles	0.687	0.313
E40-E46 Malnutrition	0.686	0.314
T81.3 Disruption of operation wound, not elsewhere classified	0.684	0.316
S42.20 Fracture of upper end of humerus (closed)	0.682	0.318
Y60-Y69 Misadventures to patients during surgical and medical care	0.682	0.318
O75 Other complications of labour and delivery, not elsewhere classified	0.682	0.318
G20-G26 Extrapyramidal and movement disorders	0.681	0.319
T42.4 Benzodiazepines	0.679	0.321
R50.0 Fever with chills	0.678	0.322
K13.0 Diseases of lips	0.677	0.323
Y85 Sequelae of transport accidents	0.677	0.323
F30-F39 Mood [affective] disorders	0.676	0.324
S68 Traumatic amputation of wrist and hand	0.675	0.324
I51.9 Heart disease, unspecified	0.675	0.325
S61 Open wound of wrist and hand	0.675	0.325
M24 Other specific joint derangements	0.675	0.325
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.675	0.325
M75.1 Rotator cuff syndrome	0.675	0.325
N18 Chronic renal failure	0.674	0.326
R53 Malaise and fatigue	0.674	0.326
E27 Other disorders of adrenal gland	0.673	0.327
M25.9 Joint disorder, unspecified	0.673	0.327
M25.8 Other specified joint disorders	0.673	0.327
M25.3 Other instability of joint	0.673	0.327
M25.2 Flail joint	0.673	0.327
M25.1 Fistula of joint	0.673	0.327
M25.0 Haemarthrosis	0.673	0.327
O20-O29 Other maternal disorders predominantly related to pregnancy	0.673	0.327
I60-I69 Cerebrovascular diseases	0.673	0.327
F05 Delirium, not induced by alcohol and other psychoactive substances	0.673	0.327
T92 Sequelae of injuries of upper limb	0.673	0.327
R69 Unknown and unspecified causes of morbidity	0.673	0.327
H43-H45 Disorders of vitreous body and globe	0.673	0.327
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.672	0.328
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.672	0.328
Z80.8 Family history of malignant neoplasm of other organs or systems	0.672	0.328
M22.4 Chondromalacia patellae	0.672	0.328
L60-L75 Disorders of skin appendages	0.671	0.329
M43 Other deforming dorsopathies	0.669	0.331
Z00-Z13 Persons encountering health services for examination and investigation	0.668	0.332
Y89 Sequelae of other external causes	0.667	0.333
Y88 Sequelae of surgical and medical care as external cause	0.667	0.333
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.667	0.333
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension	0.667	0.333
R56.8 Other and unspecified convulsions	0.666	0.334
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.665	0.335
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.665	0.335
T82.4 Mechanical complication of vascular dialysis catheter	0.665	0.335
T82.3 Mechanical complication of other vascular grafts	0.665	0.335
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.665	0.335
T82.1 Mechanical complication of cardiac electronic device	0.665	0.335
T82.0 Mechanical complication of heart valve prosthesis	0.665	0.335
Z80.4 Family history of malignant neoplasm of genital organs	0.664	0.336
R23 Other skin changes	0.664	0.336
M75.3 Calcific tendinitis of shoulder	0.664	0.336
E10.3 With ophthalmic complications	0.664	0.336
E12 Malnutrition-related diabetes mellitus	0.664	0.336
M25.54 Pain in joint (Hand)	0.663	0.337
M20.5 Other deformities of toe(s) (acquired)	0.663	0.337
M79.87 Other specified soft tissue disorders (Ankle and foot)	0.662	0.338
D37-D48 Neoplasms of uncertain or unknown behaviour	0.662	0.338
S69 Other and unspecified injuries of wrist and hand	0.662	0.338
S67 Crushing injury of wrist and hand	0.662	0.338
S65 Injury of blood vessels at wrist and hand level	0.662	0.338
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.662	0.338
S60 Superficial injury of wrist and hand	0.662	0.338
H04.5 Stenosis and insufficiency of lachrymal passages	0.662	0.338
R22.9 Localised swelling, mass and lump, unspecified	0.662	0.338
M20.3 Other deformity of hallux (acquired)	0.661	0.339
R25 Abnormal involuntary movements	0.661	0.339
C15 Malignant neoplasm of oesophagus	0.661	0.339
K14.8 Other diseases of tongue	0.661	0.339
E22 Hyperfunction of pituitary gland	0.660	0.340
I73.0 Raynaud's syndrome	0.660	0.340
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.660	0.340
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.660	0.340
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.660	0.340
T46 Poisoning by agents primarily affecting the cardiovascular system	0.660	0.340
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.660	0.340
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.660	0.340
T41 Poisoning by anaesthetics and therapeutic gases	0.660	0.340
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.660	0.340
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.660	0.340
T36 Poisoning by systemic antibiotics	0.660	0.340
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.659	0.341
O36 Maternal care for other known or suspected foetal problems	0.658	0.342
R22.4 Localised swelling, mass and lump, lower limb	0.658	0.342
R22.1 Localised swelling, mass and lump, neck	0.658	0.342
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.658	0.342
I34.8 Other nonrheumatic mitral valve disorders	0.658	0.342
I34.2 Nonrheumatic mitral (valve) stenosis	0.658	0.342
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.657	0.343
S30 Superficial injury of abdomen, lower back and pelvis	0.657	0.343
R50.2 Drug-induced fever	0.655	0.345
R50.1 Persistent fever	0.655	0.345
D09 Carcinoma in situ of other and unspecified sites	0.654	0.346
I42.9 Cardiomyopathy, unspecified	0.654	0.346
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.654	0.346
L81 Other disorders of pigmentation	0.654	0.346
G91.9 Hydrocephalus, unspecified	0.654	0.346
G45.4 Transient global amnesia	0.654	0.346
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.653	0.347
I70 Atherosclerosis	0.653	0.347
V18 Pedal cyclist injured in noncollision transport accident	0.653	0.347
M25.59 Pain in joint (Site unspecified)	0.652	0.348
M25.58 Pain in joint (Other)	0.652	0.348
M25.52 Pain in joint (Upper arm)	0.652	0.348
M25.50 Pain in joint (Multiple sites)	0.652	0.348
M79.9 Soft tissue disorder, unspecified	0.652	0.348
M79.5 Residual foreign body in soft tissue	0.652	0.348
M79.4 Hypertrophy of (infrapatellar) fat pad	0.652	0.348
M79.3 Panniculitis, unspecified	0.652	0.348
M79.2 Neuralgia and neuritis, unspecified	0.652	0.348
Z95 Presence of cardiac and vascular implants and grafts	0.651	0.349
K08 Other disorders of teeth and supporting structures	0.651	0.349
Z80.3 Family history of malignant neoplasm of breast	0.650	0.350
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.650	0.350
I72 Other aneurysm	0.650	0.350
M75.0 Adhesive capsulitis of shoulder	0.650	0.350
Z89 Acquired absence of limb	0.650	0.350
I49.8 Other specified cardiac arrhythmias	0.649	0.350
I49.4 Other and unspecified premature depolarisation	0.649	0.350
I49.2 Junctional premature depolarisation	0.649	0.350
I95.9 Hypotension, unspecified	0.648	0.352
Z97 Presence of other devices	0.648	0.352
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.647	0.353
M47 Spondylosis	0.647	0.353
T80.8 Other complications following infusion, transfusion and therapeutic injection	0.646	0.353
I25.8 Other forms of chronic ischaemic heart disease	0.646	0.354
M31 Other necrotising vasculopathies	0.646	0.354
O85-O92 Complications predominantly related to the puerperium	0.646	0.354
E10.5 With peripheral circulatory complications	0.645	0.355
O63.0 Prolonged first stage (of labour)	0.644	0.356
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.644	0.356
F03 Unspecified dementia	0.644	0.356
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.644	0.356
R41.3 Other amnesia	0.644	0.356
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.644	0.356
Y83.4 Other reconstructive surgery	0.644	0.356
J22 Unspecified acute lower respiratory infection	0.644	0.356
H55-H59 Other disorders of eye and adnexa	0.643	0.357
M79.6 Pain in limb	0.642	0.357
O94-O99 Other obstetric conditions, not elsewhere classified	0.642	0.358
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.642	0.358
E53 Deficiency of other B group vitamins	0.642	0.358
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.642	0.358
T81.9 Unspecified complication of procedure	0.641	0.358
T81.7 Vascular complications following a procedure, not elsewhere classified	0.641	0.358
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.641	0.358
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.641	0.358
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.641	0.358
G93.0 Cerebral cysts	0.641	0.359
G62.9 Polyneuropathy, unspecified	0.641	0.359
J40-J47 Chronic lower respiratory diseases	0.639	0.361
Y83.5 Amputation of limb(s)	0.636	0.364
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.636	0.364
G96 Other disorders of central nervous system	0.636	0.364
G95 Other diseases of spinal cord	0.636	0.364
G94 Other disorders of brain in diseases classified elsewhere	0.636	0.364
G90 Disorders of autonomic nervous system	0.636	0.364
G98 Other disorders of nervous system, not elsewhere classified	0.636	0.364
G92 Toxic encephalopathy	0.636	0.364
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.636	0.364
R60 Oedema, not elsewhere classified	0.636	0.364
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.636	0.364
L89.1 Stage II decubitus ulcer	0.636	0.364
G63 Polyneuropathy in diseases classified elsewhere	0.635	0.365
E55.9 Vitamin D deficiency, unspecified	0.634	0.366
G40.9 Epilepsy, unspecified	0.634	0.366
M79.7 Fibromyalgia	0.633	0.366
R22.0 Localised swelling, mass and lump, head	0.634	0.366
Y83.1 Surgical operation with implant of artificial internal device	0.633	0.367

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations