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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77525326
log Bayes Factor = 11.6055
Chromosome 5   position 95,445,855  (GRCh37) Explore rs77525326 on Ensembl!
Variant rs77525326 is part of Cluster X0133

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M50-M54 Other dorsopathies
1.000 0.000 0.000
M54 Dorsalgia
0.998 0.002 0.000
M25 Other joint disorders, not elsewhere classified
0.998 0.002 0.000
Chapter II Neoplasms
0.996 0.004 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.996 0.004 0.000
M15-M19 Arthrosis
0.995 0.005 0.000
M25.5 Pain in joint
0.993 0.007 0.000
M54.5 Low back pain
0.991 0.009 0.000
M70-M79 Other soft tissue disorders
0.984 0.016 0.000
M16 Coxarthrosis [arthrosis of hip]
0.982 0.018 0.000
Chapter VI Diseases of the nervous system
0.977 0.023 0.000
D00-D09 In situ neoplasms
0.975 0.025 0.000
S00-S09 Injuries to the head
0.972 0.028 0.000
D05 Carcinoma in situ of breast
0.963 0.037 0.000
M20 Acquired deformities of fingers and toes
0.963 0.037 0.000
M51 Other intervertebral disk disorders
0.961 0.039 0.000
M16.9 Coxarthrosis, unspecified
0.960 0.040 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.956 0.044 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.950 0.050 0.000
M54.56 Low back pain (Lumbar region)
0.949 0.051 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.948 0.052 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.940 0.060 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.940 0.060 0.000
M20.1 Hallux valgus (acquired)
0.930 0.070 0.000
D05.9 Carcinoma in situ of breast, unspecified
0.929 0.071 0.000
M19 Other arthrosis
0.929 0.071 0.000
M25.50 Pain in joint (Multiple sites)
0.929 0.071 0.000
S00 Superficial injury of head
0.929 0.071 0.000
C64-C68 Malignant neoplasms of urinary tract
0.927 0.073 0.000
M51.2 Other specified intervertebral disk displacement
0.927 0.073 0.000
M75 Shoulder lesions
0.925 0.075 0.000
E70-E90 Metabolic disorders
0.923 0.077 0.000
Chapter X Diseases of the respiratory system
0.916 0.084 0.000
M79.6 Pain in limb
0.913 0.087 0.000
M54.57 Low back pain (Lumbosacral region)
0.912 0.088 0.000
M19.9 Arthrosis, unspecified
0.904 0.096 0.000
Chapter VII Diseases of the eye and adnexa
0.903 0.097 0.000
M31 Other necrotising vasculopathies
0.901 0.099 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.900 0.100 0.000
M21 Other acquired deformities of limbs
0.899 0.101 0.000
E83 Disorders of mineral metabolism
0.898 0.102 0.000
M25.54 Pain in joint (Hand)
0.897 0.103 0.000
S00.8 Superficial injury of other parts of head
0.894 0.106 0.000
M16.0 Primary coxarthrosis, bilateral
0.891 0.109 0.000
M54.2 Cervicalgia
0.889 0.111 0.000
M54.1 Radiculopathy
0.889 0.111 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.888 0.112 0.000
S01 Open wound of head
0.886 0.114 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.885 0.115 0.000
G90-G99 Other disorders of the nervous system
0.884 0.116 0.000
M25.7 Osteophyte
0.878 0.122 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.872 0.128 0.000
M45-M49 Spondylopathies
0.870 0.130 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.867 0.133 0.000
S80-S89 Injuries to the knee and lower leg
0.867 0.133 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.866 0.134 0.000
M75.1 Rotator cuff syndrome
0.863 0.137 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.862 0.138 0.000
E20-E35 Disorders of other endocrine glands
0.860 0.140 0.000
J40-J47 Chronic lower respiratory diseases
0.857 0.143 0.000
G56 Mononeuropathies of upper limb
0.856 0.144 0.000
M65-M68 Disorders of synovium and tendon
0.855 0.145 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.853 0.147 0.000
C79 Secondary malignant neoplasm of other sites
0.846 0.154 0.000
S10-S19 Injuries to the neck
0.841 0.159 0.000
M25.53 Pain in joint (Forearm)
0.839 0.161 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.839 0.161 0.000
Chapter I Certain infectious and parasitic diseases
0.833 0.167 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.831 0.169 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.829 0.170 0.000
M31.6 Other giant cell arteritis
0.828 0.172 0.000
D05.1 Intraductal carcinoma in situ
0.828 0.172 0.000
H25-H28 Disorders of lens
0.823 0.177 0.000
C66 Malignant neoplasm of ureter
0.822 0.178 0.000
D05.0 Lobular carcinoma in situ
0.820 0.180 0.000
M20.0 Deformity of finger(s)
0.820 0.180 0.000
C78.7 Secondary malignant neoplasm of liver
0.819 0.181 0.000
M80-M85 Disorders of bone density and structure
0.819 0.181 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.817 0.183 0.000
M91-M94 Chondropathies
0.816 0.184 0.000
M79.8 Other specified soft tissue disorders
0.815 0.185 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.814 0.186 0.000
G56.2 Lesion of ulnar nerve
0.810 0.190 0.000
M54.22 Cervicalgia (Cervical region)
0.810 0.190 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.810 0.190 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.808 0.192 0.000
J30-J39 Other diseases of upper respiratory tract
0.807 0.193 0.000
E83.5 Disorders of calcium metabolism
0.806 0.194 0.000
M79.60 Pain in limb (Multiple sites)
0.804 0.196 0.000
S60-S69 Injuries to the wrist and hand
0.804 0.196 0.000
G30-G32 Other degenerative diseases of the nervous system
0.800 0.200 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.800 0.200 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.798 0.202 0.000
M51.9 Intervertebral disk disorder, unspecified
0.795 0.205 0.000
J40 Bronchitis, not specified as acute or chronic
0.793 0.207 0.000
M25.59 Pain in joint (Site unspecified)
0.793 0.207 0.000
M19.94 Arthrosis, unspecified (Hand)
0.792 0.208 0.000
M34 Systemic sclerosis
0.791 0.209 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.791 0.209 0.000
G95 Other diseases of spinal cord
0.789 0.211 0.000
M50 Cervical disk disorders
0.788 0.212 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.788 0.212 0.000
E83.1 Disorders of iron metabolism
0.787 0.213 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.783 0.217 0.000
M54.4 Lumbago with sciatica
0.783 0.217 0.000
S01.1 Open wound of eyelid and periocular area
0.783 0.217 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.783 0.217 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.780 0.220 0.000
M22 Disorders of patella
0.778 0.222 0.000
S01.8 Open wound of other parts of head
0.776 0.224 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.772 0.228 0.000
M18 Arthrosis of first carpometacarpal joint
0.767 0.233 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.767 0.233 0.000
M24 Other specific joint derangements
0.766 0.234 0.000
E83.3 Disorders of phosphorus metabolism
0.764 0.236 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.762 0.238 0.000
C44 Other malignant neoplasms of skin
0.762 0.238 0.000
M54.9 Dorsalgia, unspecified
0.761 0.239 0.000
C78.2 Secondary malignant neoplasm of pleura
0.759 0.241 0.000
H55-H59 Other disorders of eye and adnexa
0.759 0.241 0.000
M16.7 Other secondary coxarthrosis
0.758 0.242 0.000
Chapter XXII Codes for special purposes
0.756 0.244 0.000
C78.0 Secondary malignant neoplasm of lung
0.756 0.244 0.000
M75.3 Calcific tendinitis of shoulder
0.756 0.244 0.000
M67 Other disorders of synovium and tendon
0.755 0.245 0.000
M25.77 Osteophyte (Ankle and foot)
0.753 0.247 0.000
E86 Volume depletion
0.753 0.247 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.753 0.247 0.000
S40-S49 Injuries to the shoulder and upper arm
0.752 0.248 0.000
M25.8 Other specified joint disorders
0.752 0.248 0.000
T79-T79 Certain early complications of trauma
0.751 0.248 0.000
M25.9 Joint disorder, unspecified
0.750 0.249 0.000
M21.2 Flexion deformity
0.750 0.249 0.000
M25.76 Osteophyte (Lower leg)
0.749 0.251 0.000
M60-M63 Disorders of muscles
0.749 0.251 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.748 0.252 0.000
S01.5 Open wound of lip and oral cavity
0.748 0.252 0.000
M47 Spondylosis
0.747 0.253 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.744 0.256 0.000
S00.0 Superficial injury of scalp
0.742 0.258 0.000
M79.62 Pain in limb (Upper arm)
0.739 0.261 0.000
J42 Unspecified chronic bronchitis
0.739 0.261 0.000
M05-M14 Inflammatory polyarthropathies
0.739 0.261 0.000
M79.5 Residual foreign body in soft tissue
0.736 0.264 0.000
M54.59 Low back pain (Site unspecified)
0.736 0.264 0.000
M20.3 Other deformity of hallux (acquired)
0.734 0.265 0.000
M79.2 Neuralgia and neuritis, unspecified
0.734 0.265 0.000
M00-M03 Infectious arthropathies
0.734 0.266 0.000
J46 Status asthmaticus
0.733 0.267 0.000
M20.4 Other hammer toe(s) (acquired)
0.733 0.267 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.732 0.268 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.730 0.270 0.000
M54.6 Pain in thoracic spine
0.729 0.271 0.000
S12 Fracture of neck
0.728 0.272 0.000
M79.1 Myalgia
0.727 0.273 0.000
M54.19 Radiculopathy (Site unspecified)
0.724 0.276 0.000
H30-H36 Disorders of choroid and retina
0.724 0.276 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.724 0.276 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.723 0.277 0.000
H25 Senile cataract
0.723 0.277 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.723 0.277 0.000
M54.50 Low back pain (Multiple sites in spine)
0.722 0.278 0.000
M75.5 Bursitis of shoulder
0.722 0.278 0.000
C43 Malignant melanoma of skin
0.721 0.279 0.000
M25.78 Osteophyte (Other)
0.721 0.279 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.721 0.279 0.000
M25.52 Pain in joint (Upper arm)
0.719 0.281 0.000
S00.3 Superficial injury of nose
0.718 0.282 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C44.4 Skin of scalp and neck
0.717 0.283 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.716 0.284 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.716 0.284 0.000
M54.8 Other dorsalgia
0.716 0.284 0.000
M54.0 Panniculitis affecting regions of neck and back
0.716 0.284 0.000
M25.3 Other instability of joint
0.715 0.284 0.000
M25.2 Flail joint
0.715 0.284 0.000
M25.1 Fistula of joint
0.715 0.284 0.000
M25.0 Haemarthrosis
0.715 0.284 0.000
M40-M43 Deforming dorsopathies
0.715 0.285 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.715 0.285 0.000
G95.2 Cord compression, unspecified
0.715 0.285 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.714 0.285 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.714 0.285 0.000
M75.9 Shoulder lesion, unspecified
0.714 0.286 0.000
T33-T35 Frostbite
0.714 0.286 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.714 0.286 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.714 0.286 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.714 0.286 0.000
T00-T07 Injuries involving multiple body regions
0.714 0.286 0.000
G40-G47 Episodic and paroxysmal disorders
0.714 0.286 0.000
M21.3 Wrist or foot drop (acquired)
0.714 0.286 0.000
M25.51 Pain in joint (Shoulder region)
0.713 0.286 0.000
M15 Polyarthrosis
0.713 0.287 0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)
0.713 0.287 0.000
G58 Other mononeuropathies
0.713 0.287 0.000
E29 Testicular dysfunction
0.713 0.287 0.000
M25.58 Pain in joint (Other)
0.712 0.288 0.000
S05 Injury of eye and orbit
0.711 0.289 0.000
M54.55 Low back pain (Thoracolumbar region)
0.710 0.290 0.000
M54.54 Low back pain-Thoracic
0.710 0.290 0.000
M54.53 Low back pain-Cervicothoracic
0.710 0.290 0.000
M54.52 Low back pain-Cervical
0.710 0.290 0.000
M54.51 Low back pain-Occipit-atl-axl
0.710 0.290 0.000
Q80-Q89 Other congenital malformations
0.710 0.290 0.000
E85 Amyloidosis
0.710 0.290 0.000
S81 Open wound of lower leg
0.710 0.290 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.710 0.290 0.000
M54.16 Radiculopathy (Lumbar region)
0.708 0.292 0.000
M79.66 Pain in limb (Lower leg)
0.708 0.292 0.000
S90-S99 Injuries to the ankle and foot
0.707 0.293 0.000
G30 Alzheimer's disease
0.707 0.293 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.706 0.294 0.000
M76 Enthesopathies of lower limb, excluding foot
0.705 0.294 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.705 0.294 0.000
Q50-Q56 Congenital malformations of genital organs
0.705 0.295 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.704 0.296 0.000
M16.5 Other posttraumatic coxarthrosis
0.704 0.296 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.704 0.296 0.000
M16.3 Other dysplastic coxarthrosis
0.704 0.296 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.704 0.296 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.704 0.296 0.000
M50.3 Other cervical disk degeneration
0.704 0.296 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.699 0.301 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.699 0.301 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.699 0.301 0.000
M21.1 Varus deformity, not elsewhere classified
0.698 0.302 0.000
Chapter VIII Diseases of the ear and mastoid process
0.698 0.302 0.000
J34 Other disorders of nose and nasal sinuses
0.698 0.302 0.000
S08 Traumatic amputation of part of head
0.697 0.303 0.000
S07 Crushing injury of head
0.697 0.303 0.000
S04 Injury of cranial nerves
0.697 0.303 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.697 0.303 0.000
J20-J22 Other acute lower respiratory infections
0.696 0.304 0.000
S06 Intracranial injury
0.695 0.305 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.695 0.305 0.000
E40-E46 Malnutrition
0.694 0.306 0.000
M53 Other dorsopathies, not elsewhere classified
0.692 0.308 0.000
D09 Carcinoma in situ of other and unspecified sites
0.691 0.309 0.000
D05.7 Other carcinoma in situ of breast
0.691 0.309 0.000
G54 Nerve root and plexus disorders
0.690 0.309 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.690 0.310 0.000
M79.63 Pain in limb (Forearm)
0.690 0.310 0.000
H26 Other cataract
0.689 0.311 0.000
M51.3 Other specified intervertebral disk degeneration
0.689 0.311 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.689 0.311 0.000
M51.4 Schmorl's nodes
0.689 0.311 0.000
E23 Hypofunction and other disorders of pituitary gland
0.689 0.311 0.000
M54.17 Radiculopathy (Lumbosacral region)
0.689 0.311 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.689 0.311 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.689 0.311 0.000
E83.4 Disorders of magnesium metabolism
0.687 0.313 0.000
M21.6 Other acquired deformities of ankle and foot
0.687 0.313 0.000
E28 Ovarian dysfunction
0.686 0.314 0.000
M79.9 Soft tissue disorder, unspecified
0.685 0.314 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.685 0.314 0.000
M79.3 Panniculitis, unspecified
0.685 0.314 0.000
M94 Other disorders of cartilage
0.684 0.316 0.000
C09 Malignant neoplasm of tonsil
0.683 0.317 0.000
G97.8 Other postprocedural disorders of nervous system
0.683 0.317 0.000
T93 Sequelae of injuries of lower limb
0.683 0.317 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.682 0.318 0.000
M48 Other spondylopathies
0.681 0.319 0.000
E89.0 Postprocedural hypothyroidism
0.681 0.319 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.680 0.320 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.680 0.320 0.000
G52 Disorders of other cranial nerves
0.680 0.320 0.000
G57 Mononeuropathies of lower limb
0.679 0.321 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.678 0.322 0.000
E16 Other disorders of pancreatic internal secretion
0.676 0.324 0.000
S02 Fracture of skull and facial bones
0.676 0.324 0.000
D03 Melanoma in situ
0.675 0.325 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.675 0.325 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.674 0.326 0.000
T66-T78 Other and unspecified effects of external causes
0.674 0.326 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.673 0.326 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.671 0.329 0.000
S86 Injury of muscle and tendon at lower leg level
0.671 0.329 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.671 0.329 0.000
T92 Sequelae of injuries of upper limb
0.671 0.329 0.000
M67.8 Other specified disorders of synovium and tendon
0.671 0.329 0.000
E88 Other metabolic disorders
0.671 0.329 0.000
J60-J70 Lung diseases due to external agents
0.670 0.330 0.000
M84 Disorders of continuity of bone
0.669 0.331 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.668 0.332 0.000
H25.8 Other senile cataract
0.667 0.333 0.000
M10 Gout
0.667 0.333 0.000
M19.8 Other specified arthrosis
0.666 0.334 0.000
M19.2 Other secondary arthrosis
0.666 0.334 0.000
J43 Emphysema
0.666 0.334 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.666 0.334 0.000
S00.7 Multiple superficial injuries of head
0.666 0.334 0.000
S00.5 Superficial injury of lip and oral cavity
0.666 0.334 0.000
S00.4 Superficial injury of ear
0.666 0.334 0.000
J33 Nasal polyp
0.666 0.334 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.665 0.335 0.000
C65 Malignant neoplasm of renal pelvis
0.665 0.335 0.000
C44.3 Skin of other and unspecified parts of face
0.665 0.335 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.664 0.336 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.664 0.336 0.000
D04 Carcinoma in situ of skin
0.663 0.336 0.000
M75.8 Other shoulder lesions
0.663 0.337 0.000
J09-J18 Influenza and pneumonia
0.662 0.338 0.000
J37 Chronic laryngitis and laryngotracheitis
0.662 0.338 0.000
E84 Cystic fibrosis
0.662 0.338 0.000
E79 Disorders of purine and pyrimidine metabolism
0.662 0.338 0.000
E77 Disorders of glycoprotein metabolism
0.662 0.338 0.000
E76 Disorders of glycosaminoglycan metabolism
0.662 0.338 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.662 0.338 0.000
E74 Other disorders of carbohydrate metabolism
0.662 0.338 0.000
E73 Lactose intolerance
0.662 0.338 0.000
E72 Other disorders of amino-acid metabolism
0.662 0.338 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.662 0.338 0.000
E70 Disorders of aromatic amino-acid metabolism
0.662 0.338 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.662 0.338 0.000
E89.2 Postprocedural hypoparathyroidism
0.660 0.340 0.000
T90 Sequelae of injuries of head
0.660 0.340 0.000
H10-H13 Disorders of conjunctiva
0.659 0.341 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.658 0.342 0.000
E26 Hyperaldosteronism
0.658 0.342 0.000
A00-A09 Intestinal infectious diseases
0.658 0.342 0.000
S32 Fracture of lumbar spine and pelvis
0.657 0.342 0.000
M79.82 Other specified soft tissue disorders (Upper arm)
0.657 0.343 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.657 0.343 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.656 0.343 0.000
M71 Other bursopathies
0.655 0.345 0.000
M31.3 Wegener's granulomatosis
0.655 0.345 0.000
Q00-Q07 Congenital malformations of the nervous system
0.655 0.345 0.000
M79.68 Pain in limb (Other)
0.655 0.345 0.000
M79.61 Pain in limb (Shoulder region)
0.655 0.345 0.000
D10-D36 Benign neoplasms
0.654 0.346 0.000
G70-G73 Diseases of myoneural junction and muscle
0.654 0.346 0.000
E22 Hyperfunction of pituitary gland
0.653 0.347 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.653 0.347 0.000
M51.8 Other specified intervertebral disk disorders
0.653 0.347 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.653 0.347 0.000
J38.3 Other diseases of vocal cords
0.651 0.349 0.000
J30 Vasomotor and allergic rhinitis
0.651 0.349 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.651 0.349 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.650 0.350 0.000
S61 Open wound of wrist and hand
0.650 0.350 0.000
S00.1 Contusion of eyelid and periocular area
0.649 0.351 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.648 0.352 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.647 0.353 0.000
M31.9 Necrotising vasculopathy, unspecified
0.646 0.354 0.000
M31.8 Other specified necrotising vasculopathies
0.646 0.354 0.000
M31.7 Microscopic polyangiitis
0.646 0.354 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.646 0.354 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.646 0.354 0.000
M31.2 Lethal midline granuloma
0.646 0.354 0.000
M31.1 Thrombotic microangiopathy
0.646 0.354 0.000
M31.0 Hypersensitivity angiitis
0.646 0.354 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.646 0.354 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.646 0.354 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.645 0.355 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.645 0.355 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.644 0.355 0.000
M21.9 Acquired deformity of limb, unspecified
0.644 0.356 0.000
M21.8 Other specified acquired deformities of limbs
0.644 0.356 0.000
M21.7 Unequal limb length (acquired)
0.644 0.356 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.644 0.356 0.000
M21.4 Flat foot [pes planus] (acquired)
0.644 0.356 0.000
M21.27 Flexion deformity (Ankle and foot)
0.644 0.356 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.644 0.356 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.644 0.356 0.000
E83.8 Other disorders of mineral metabolism
0.644 0.356 0.000
E83.2 Disorders of zinc metabolism
0.644 0.356 0.000
E83.0 Disorders of copper metabolism
0.644 0.356 0.000
M77 Other enthesopathies
0.643 0.357 0.000
E24 Cushing's syndrome
0.642 0.358 0.000
M86-M90 Other osteopathies
0.642 0.358 0.000
S20-S29 Injuries to the thorax
0.642 0.358 0.000
G30.9 Alzheimer's disease, unspecified
0.641 0.359 0.000
M34.9 Systemic sclerosis, unspecified
0.641 0.359 0.000
M75.4 Impingement syndrome of shoulder
0.641 0.359 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.639 0.361 0.000
G12 Spinal muscular atrophy and related syndromes
0.638 0.361 0.000
M72 Fibroblastic disorders
0.638 0.362 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.638 0.362 0.000
M19.1 Posttraumatic arthrosis of other joints
0.638 0.362 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.637 0.362 0.000
M54.29 Cervicalgia-Site unspe
0.637 0.363 0.000
M54.28 Cervicalgia-Sacral/sacrococ
0.637 0.363 0.000
M54.27 Cervicalgia-Lumbosacral
0.637 0.363 0.000
M54.26 Cervicalgia-Lumbar
0.637 0.363 0.000
M54.25 Cervicalgia-Thoracolumbar
0.637 0.363 0.000
M54.24 Cervicalgia-Thoracic
0.637 0.363 0.000
M54.23 Cervicalgia (Cervicothoracic region)
0.637 0.363 0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)
0.637 0.363 0.000
M54.20 Cervicalgia-Mult site
0.637 0.363 0.000
M54.15 Radiculopathy (Thoracolumbar region)
0.637 0.363 0.000
M54.14 Radiculopathy (Thoracic region)
0.637 0.363 0.000
M54.13 Radiculopathy (Cervicothoracic region)
0.637 0.363 0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)
0.637 0.363 0.000
M54.10 Radiculopathy (Multiple sites in spine)
0.637 0.363 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.637 0.363 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.637 0.363 0.000
M21.0 Valgus deformity, not elsewhere classified
0.637 0.363 0.000
M79.67 Pain in limb (Ankle and foot)
0.636 0.364 0.000
S01.7 Multiple open wounds of head
0.635 0.364 0.000
S01.4 Open wound of cheek and temporomandibular area
0.635 0.364 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.634 0.365 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.634 0.366 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.634 0.366 0.000
G90 Disorders of autonomic nervous system
0.634 0.366 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.634 0.366 0.000
G92 Toxic encephalopathy
0.634 0.366 0.000
S70-S79 Injuries to the hip and thigh
0.633 0.367 0.000
D06 Carcinoma in situ of cervix uteri
0.632 0.368 0.000
J38.4 Oedema of larynx
0.632 0.368 0.000
M82 Osteoporosis in diseases classified elsewhere
0.631 0.369 0.000
D45 Polycythaemia vera
0.630 0.370 0.000
M25.79 Osteophyte (Site unspecified)
0.629 0.370 0.000
M25.73 Osteophyte (Forearm)
0.629 0.370 0.000
M25.72 Osteophyte (Upper arm)
0.629 0.370 0.000
M25.70 Osteophyte (Multiple sites)
0.629 0.370 0.000
M45 Ankylosing spondylitis
0.629 0.370 0.000
S64 Injury of nerves at wrist and hand level
0.629 0.371 0.000
A30-A49 Other bacterial diseases
0.629 0.371 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.628 0.372 0.000
M79.0 Rheumatism, unspecified
0.628 0.372 0.000
G56.8 Other mononeuropathies of upper limb
0.627 0.373 0.000
C80 Malignant neoplasm without specification of site
0.626 0.374 0.000
M79.69 Pain in limb (Site unspecified)
0.626 0.374 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.625 0.375 0.000
M22.2 Patellofemoral disorders
0.625 0.375 0.000
H35 Other retinal disorders
0.625 0.375 0.000
J90-J94 Other diseases of pleura
0.624 0.376 0.000
M49 Spondylopathies in diseases classified elsewhere
0.624 0.376 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.622 0.377 0.000
J34.3 Hypertrophy of nasal turbinates
0.623 0.377 0.000
M75.2 Bicipital tendinitis
0.622 0.377 0.000
B25-B34 Other viral diseases
0.622 0.378 0.000
S88 Traumatic amputation of lower leg
0.622 0.378 0.000
S87 Crushing injury of lower leg
0.622 0.378 0.000
S85 Injury of blood vessels at lower leg level
0.622 0.378 0.000
S84 Injury of nerves at lower leg level
0.622 0.378 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.621 0.379 0.000
H55 Nystagmus and other irregular eye movements
0.621 0.379 0.000
S09 Other and unspecified injuries of head
0.621 0.379 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.621 0.379 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.621 0.379 0.000
M46 Other inflammatory spondylopathies
0.620 0.380 0.000
B99-B99 Other infectious diseases
0.620 0.380 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.619 0.380 0.000
G51 Facial nerve disorders
0.619 0.381 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.619 0.381 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.618 0.382 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.618 0.382 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.618 0.382 0.000
Q35-Q37 Cleft lip and cleft palate
0.618 0.382 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.618 0.382 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.618 0.382 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.617 0.383 0.000
E34 Other endocrine disorders
0.617 0.383 0.000
E32 Diseases of thymus
0.617 0.383 0.000
E31 Polyglandular dysfunction
0.617 0.383 0.000
E30 Disorders of puberty, not elsewhere classified
0.617 0.383 0.000
E25 Adrenogenital disorders
0.617 0.383 0.000
E20 Hypoparathyroidism
0.617 0.383 0.000
M85 Other disorders of bone density and structure
0.617 0.383 0.000
M25.4 Effusion of joint
0.616 0.384 0.000
M10.9 Gout, unspecified
0.615 0.385 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.615 0.385 0.000
J41 Simple and mucopurulent chronic bronchitis
0.614 0.386 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.614 0.386 0.000
G56.4 Causalgia
0.614 0.386 0.000
G56.3 Lesion of radial nerve
0.614 0.386 0.000
G56.1 Other lesions of median nerve
0.614 0.386 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.613 0.387 0.000
M66 Spontaneous rupture of synovium and tendon
0.613 0.387 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.613 0.387 0.000
M23 Internal derangement of knee
0.612 0.388 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.612 0.388 0.000
B15-B19 Viral hepatitis
0.612 0.388 0.000
T98 Sequelae of other and unspecified effects of external causes
0.612 0.388 0.000
T95 Sequelae of burns, corrosions and frostbite
0.612 0.388 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.612 0.388 0.000
T91 Sequelae of injuries of neck and trunk
0.612 0.388 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.612 0.388 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.612 0.388 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.611 0.389 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.610 0.389 0.000
S80 Superficial injury of lower leg
0.610 0.390 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.609 0.390 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.609 0.391 0.000
G91 Hydrocephalus
0.608 0.392 0.000
B35-B49 Mycoses
0.608 0.392 0.000
S19 Other and unspecified injuries of neck
0.608 0.392 0.000
C92 Myeloid leukaemia
0.607 0.393 0.000
E29.1 Testicular hypofunction
0.607 0.393 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.607 0.393 0.000
C79.6 Secondary malignant neoplasm of ovary
0.606 0.394 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.606 0.394 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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