TreeWAS – Variant ID: rs77580845

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
Z88.0 Personal history of allergy to penicillin	0.999	0.001	0.000
M20-M25 Other joint disorders	0.997	0.003	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.997	0.003	0.000
Chapter V Mental and behavioural disorders	0.996	0.004	0.000
Chapter XIV Diseases of the genitourinary system	0.996	0.004	0.000
M05-M14 Inflammatory polyarthropathies	0.991	0.009	0.000
M25 Other joint disorders, not elsewhere classified	0.986	0.014	0.000
M70-M79 Other soft tissue disorders	0.983	0.017	0.000
M13 Other arthritis	0.981	0.019	0.000
N10-N16 Renal tubulo-interstitial diseases	0.978	0.022	0.000
M13.9 Arthritis, unspecified	0.975	0.025	0.000
N60-N64 Disorders of breast	0.967	0.033	0.000
Chapter I Certain infectious and parasitic diseases	0.967	0.033	0.000
M25.7 Osteophyte	0.962	0.038	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.958	0.042	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.955	0.045	0.000
F30-F39 Mood [affective] disorders	0.954	0.046	0.000
N13 Obstructive and reflux uropathy	0.950	0.050	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.949	0.051	0.000
N80-N98 Noninflammatory disorders of female genital tract	0.944	0.056	0.000
Chapter II Neoplasms	0.940	0.060	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.937	0.063	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.933	0.067	0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle	0.932	0.068	0.000
M75 Shoulder lesions	0.930	0.070	0.000
S60-S69 Injuries to the wrist and hand	0.927	0.073	0.000
M13.94 Arthritis, unspecified (Hand)	0.925	0.075	0.000
N94.6 Dysmenorrhoea, unspecified	0.924	0.076	0.000
N64 Other disorders of breast	0.921	0.079	0.000
Chapter VI Diseases of the nervous system	0.915	0.085	0.000
M50-M54 Other dorsopathies	0.913	0.087	0.000
N13.3 Other and unspecified hydronephrosis	0.911	0.089	0.000
E65-E68 Obesity and other hyperalimentation	0.907	0.093	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.907	0.093	0.000
N85 Other noninflammatory disorders of uterus, except cervix	0.906	0.094	0.000
M65-M68 Disorders of synovium and tendon	0.902	0.098	0.000
F33 Recurrent depressive disorder	0.899	0.101	0.000
M45-M49 Spondylopathies	0.889	0.111	0.000
M20 Acquired deformities of fingers and toes	0.885	0.115	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.884	0.116	0.000
M24 Other specific joint derangements	0.883	0.117	0.000
M75.4 Impingement syndrome of shoulder	0.881	0.119	0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.879	0.121	0.000
M25.76 Osteophyte (Lower leg)	0.874	0.126	0.000
E66 Obesity	0.874	0.126	0.000
M40-M43 Deforming dorsopathies	0.873	0.127	0.000
N85.4 Malposition of uterus	0.870	0.130	0.000
A30-A49 Other bacterial diseases	0.870	0.130	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.870	0.130	0.000
F41 Other anxiety disorders	0.864	0.136	0.000
S70-S79 Injuries to the hip and thigh	0.861	0.139	0.000
R02 Gangrene, not elsewhere classified	0.861	0.139	0.000
Chapter XXII Codes for special purposes	0.860	0.140	0.000
E70-E90 Metabolic disorders	0.852	0.148	0.000
B95-B98 Bacterial, viral and other infectious agents	0.851	0.149	0.000
F31 Bipolar affective disorder	0.850	0.150	0.000
M20.5 Other deformities of toe(s) (acquired)	0.848	0.152	0.000
D00-D09 In situ neoplasms	0.848	0.152	0.000
E66.9 Obesity, unspecified	0.846	0.154	0.000
N64.1 Fat necrosis of breast	0.846	0.154	0.000
S00-S09 Injuries to the head	0.842	0.158	0.000
S80-S89 Injuries to the knee and lower leg	0.842	0.158	0.000
F41.2 Mixed anxiety and depressive disorder	0.841	0.159	0.000
F43 Reaction to severe stress, and adjustment disorders	0.841	0.159	0.000
D45 Polycythaemia vera	0.840	0.160	0.000
F33.9 Recurrent depressive disorder, unspecified	0.840	0.160	0.000
M25.5 Pain in joint	0.837	0.163	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.837	0.163	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.835	0.165	0.000
M13.98 Arthritis, unspecified (Other)	0.832	0.168	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.831	0.169	0.000
M05 Seropositive rheumatoid arthritis	0.828	0.172	0.000
S66 Injury of muscle and tendon at wrist and hand level	0.828	0.172	0.000
M54 Dorsalgia	0.827	0.173	0.000
N62 Hypertrophy of breast	0.825	0.175	0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.825	0.175	0.000
N97 Female infertility	0.824	0.176	0.000
G20-G26 Extrapyramidal and movement disorders	0.822	0.178	0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.822	0.178	0.000
T79-T79 Certain early complications of trauma	0.819	0.181	0.000
N10 Acute tubulo-interstitial nephritis	0.818	0.182	0.000
M72 Fibroblastic disorders	0.818	0.182	0.000
M25.77 Osteophyte (Ankle and foot)	0.813	0.187	0.000
B15-B19 Viral hepatitis	0.813	0.187	0.000
G90-G99 Other disorders of the nervous system	0.811	0.189	0.000
M80-M85 Disorders of bone density and structure	0.811	0.189	0.000
E89.0 Postprocedural hypothyroidism	0.809	0.191	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.807	0.193	0.000
E20-E35 Disorders of other endocrine glands	0.806	0.194	0.000
N60 Benign mammary dysplasia	0.800	0.199	0.000
S64 Injury of nerves at wrist and hand level	0.800	0.200	0.000
M91-M94 Chondropathies	0.800	0.200	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.799	0.201	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.797	0.203	0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle	0.796	0.204	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.794	0.206	0.000
M14 Arthropathies in other diseases classified elsewhere	0.793	0.207	0.000
N13.8 Other obstructive and reflux uropathy	0.792	0.208	0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.789	0.211	0.000
F03 Unspecified dementia	0.789	0.211	0.000
C09 Malignant neoplasm of tonsil	0.788	0.212	0.000
A41 Other septicaemia	0.787	0.212	0.000
M23 Internal derangement of knee	0.785	0.215	0.000
N20-N23 Urolithiasis	0.785	0.215	0.000
M47 Spondylosis	0.783	0.217	0.000
M13.90 Arthritis, unspecified (Multiple sites)	0.782	0.218	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.782	0.218	0.000
N89 Other noninflammatory disorders of vagina	0.781	0.219	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.781	0.219	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.780	0.220	0.000
B25-B34 Other viral diseases	0.780	0.220	0.000
S40-S49 Injuries to the shoulder and upper arm	0.780	0.220	0.000
F40 Phobic anxiety disorders	0.777	0.223	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.776	0.224	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.776	0.224	0.000
S20-S29 Injuries to the thorax	0.776	0.224	0.000
B35-B49 Mycoses	0.775	0.225	0.000
M75.2 Bicipital tendinitis	0.773	0.227	0.000
G20 Parkinson's disease	0.773	0.227	0.000
N64.5 Other signs and symptoms in breast	0.772	0.228	0.000
R01 Cardiac murmurs and other cardiac sounds	0.768	0.232	0.000
N99-N99 Other disorders of the genitourinary system	0.768	0.232	0.000
M25.3 Other instability of joint	0.768	0.232	0.000
M67 Other disorders of synovium and tendon	0.767	0.233	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.766	0.234	0.000
M43 Other deforming dorsopathies	0.764	0.236	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.763	0.237	0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.762	0.238	0.000
M51 Other intervertebral disk disorders	0.762	0.238	0.000
M48 Other spondylopathies	0.761	0.239	0.000
M25.56 Pain in joint (Lower leg)	0.760	0.240	0.000
Chapter VII Diseases of the eye and adnexa	0.760	0.240	0.000
R05 Cough	0.760	0.240	0.000
F80-F89 Disorders of psychological development	0.759	0.241	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.758	0.242	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.754	0.246	0.000
M25.78 Osteophyte (Other)	0.754	0.246	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.753	0.247	0.000
S06 Intracranial injury	0.751	0.249	0.000
M21 Other acquired deformities of limbs	0.751	0.249	0.000
T66-T78 Other and unspecified effects of external causes	0.751	0.249	0.000
M00-M03 Infectious arthropathies	0.750	0.250	0.000
M77 Other enthesopathies	0.750	0.250	0.000
E40-E46 Malnutrition	0.749	0.251	0.000
Chapter X Diseases of the respiratory system	0.749	0.251	0.000
R06 Abnormalities of breathing	0.748	0.252	0.000
E50-E64 Other nutritional deficiencies	0.747	0.252	0.000
S10-S19 Injuries to the neck	0.747	0.253	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.745	0.255	0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.742	0.258	0.000
M06 Other rheumatoid arthritis	0.742	0.258	0.000
M25.74 Osteophyte (Hand)	0.741	0.259	0.000
M76 Enthesopathies of lower limb, excluding foot	0.741	0.259	0.000
N91 Absent, scanty and rare menstruation	0.741	0.259	0.000
M25.71 Osteophyte (Shoulder region)	0.740	0.260	0.000
N13.4 Hydroureter	0.738	0.262	0.000
H53-H54 Visual disturbances and blindness	0.738	0.262	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.737	0.263	0.000
M86-M90 Other osteopathies	0.737	0.263	0.000
M54.2 Cervicalgia	0.736	0.264	0.000
D04 Carcinoma in situ of skin	0.735	0.265	0.000
N13.2 Hydronephrosis with renal and ureteral calculous obstruction	0.734	0.266	0.000
T43.2 Other and unspecified antidepressants	0.733	0.267	0.000
M75.0 Adhesive capsulitis of shoulder	0.733	0.267	0.000
M65 Synovitis and tenosynovitis	0.731	0.269	0.000
C09.9 Tonsil, unspecified	0.730	0.270	0.000
S70 Superficial injury of hip and thigh	0.729	0.271	0.000
N85.6 Intra-uterine synechiae	0.729	0.271	0.000
N85.2 Hypertrophy of uterus	0.729	0.271	0.000
G99 Other disorders of nervous system in diseases classified elsewhere	0.729	0.271	0.000
N92 Excessive, frequent and irregular menstruation	0.728	0.272	0.000
H53 Visual disturbances	0.727	0.273	0.000
N13.9 Obstructive and reflux uropathy, unspecified	0.726	0.274	0.000
N11 Chronic tubulo-interstitial nephritis	0.725	0.275	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.722	0.278	0.000
D06 Carcinoma in situ of cervix uteri	0.722	0.278	0.000
N70-N77 Inflammatory diseases of female pelvic organs	0.721	0.279	0.000
N64.9 Disorder of breast, unspecified	0.720	0.279	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.718	0.282	0.000
M60-M63 Disorders of muscles	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
N85.8 Other specified noninflammatory disorders of uterus	0.716	0.284	0.000
C01 Malignant neoplasm of base of tongue	0.716	0.284	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.715	0.285	0.000
M34 Systemic sclerosis	0.715	0.285	0.000
M33 Dermatopolymyositis	0.715	0.285	0.000
M32 Systemic lupus erythematosus	0.715	0.285	0.000
M30 Polyarteritis nodosa and related conditions	0.715	0.285	0.000
T33-T35 Frostbite	0.714	0.285	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.714	0.285	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.714	0.285	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.714	0.285	0.000
T00-T07 Injuries involving multiple body regions	0.714	0.285	0.000
F99-F99 Unspecified mental disorder	0.714	0.286	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.714	0.286	0.000
F70-F79 Mental retardation	0.714	0.286	0.000
F60-F69 Disorders of adult personality and behaviour	0.714	0.286	0.000
C15-C26 Malignant neoplasms of digestive organs	0.713	0.287	0.000
A80-A89 Viral infections of the central nervous system	0.712	0.288	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.712	0.288	0.000
F31.9 Bipolar affective disorder, unspecified	0.712	0.288	0.000
F33.1 Recurrent depressive disorder, current episode moderate	0.711	0.289	0.000
F00 Dementia in Alzheimer's disease	0.711	0.289	0.000
M24.2 Disorder of ligament	0.711	0.289	0.000
M12 Other specific arthropathies	0.711	0.289	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.711	0.289	0.000
M08 Juvenile arthritis	0.711	0.289	0.000
M31 Other necrotising vasculopathies	0.711	0.289	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.709	0.291	0.000
M25.9 Joint disorder, unspecified	0.707	0.293	0.000
M25.2 Flail joint	0.707	0.293	0.000
M25.1 Fistula of joint	0.707	0.293	0.000
M25.0 Haemarthrosis	0.707	0.293	0.000
M75.1 Rotator cuff syndrome	0.706	0.294	0.000
M66 Spontaneous rupture of synovium and tendon	0.706	0.294	0.000
M71 Other bursopathies	0.705	0.295	0.000
N60.8 Other benign mammary dysplasias	0.705	0.295	0.000
A41.5 Septicaemia due to other Gram-negative organisms	0.705	0.295	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.705	0.295	0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level	0.704	0.296	0.000
M13.8 Other specified arthritis	0.704	0.296	0.000
M13.1 Monoarthritis, not elsewhere classified	0.704	0.296	0.000
M13.0 Polyarthritis, unspecified	0.704	0.296	0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere	0.701	0.299	0.000
N15 Other renal tubulo-interstitial diseases	0.701	0.299	0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions	0.701	0.299	0.000
Chapter XX External causes of morbidity and mortality	0.701	0.299	0.000
R47-R49 Symptoms and signs involving speech and voice	0.700	0.300	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.700	0.300	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.699	0.300	0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]	0.699	0.301	0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.699	0.301	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.699	0.301	0.000
M13.93 Arthritis, unspecified (Forearm)	0.699	0.301	0.000
M13.92 Arthritis, unspecified (Upper arm)	0.699	0.301	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.698	0.302	0.000
R06.5 Mouth breathing	0.697	0.303	0.000
S71 Open wound of hip and thigh	0.696	0.304	0.000
M22 Disorders of patella	0.695	0.304	0.000
M25.8 Other specified joint disorders	0.694	0.306	0.000
G30-G32 Other degenerative diseases of the nervous system	0.693	0.307	0.000
B99-B99 Other infectious diseases	0.693	0.307	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.693	0.307	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.693	0.307	0.000
B65-B83 Helminthiases	0.693	0.307	0.000
B50-B64 Protozoal diseases	0.693	0.307	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.693	0.307	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.693	0.307	0.000
A75-A79 Rickettsioses	0.693	0.307	0.000
A70-A74 Other diseases caused by chlamydiae	0.693	0.307	0.000
A65-A69 Other spirochaetal diseases	0.693	0.307	0.000
A20-A28 Certain zoonotic bacterial diseases	0.693	0.307	0.000
A15-A19 Tuberculosis	0.693	0.307	0.000
S01 Open wound of head	0.693	0.307	0.000
D41.4 Bladder	0.692	0.308	0.000
T79 Certain early complications of trauma, not elsewhere classified	0.692	0.308	0.000
F43.2 Adjustment disorders	0.692	0.308	0.000
S61 Open wound of wrist and hand	0.692	0.308	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.691	0.309	0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters	0.691	0.309	0.000
D48.5 Skin	0.690	0.310	0.000
N97.9 Female infertility, unspecified	0.690	0.310	0.000
C51-C58 Malignant neoplasms of female genital organs	0.690	0.310	0.000
M25.79 Osteophyte (Site unspecified)	0.689	0.311	0.000
M25.73 Osteophyte (Forearm)	0.689	0.311	0.000
M25.72 Osteophyte (Upper arm)	0.689	0.311	0.000
M25.70 Osteophyte (Multiple sites)	0.689	0.311	0.000
R01.1 Cardiac murmur, unspecified	0.689	0.311	0.000
E86 Volume depletion	0.689	0.311	0.000
F43.1 Posttraumatic stress disorder	0.688	0.311	0.000
R26 Abnormalities of gait and mobility	0.688	0.312	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.688	0.312	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.688	0.312	0.000
S02 Fracture of skull and facial bones	0.688	0.312	0.000
D41.0 Kidney	0.687	0.313	0.000
M20.0 Deformity of finger(s)	0.687	0.313	0.000
F48 Other neurotic disorders	0.687	0.313	0.000
F45 Somatoform disorders	0.687	0.313	0.000
F44 Dissociative [conversion] disorders	0.687	0.313	0.000
F42 Obsessive-compulsive disorder	0.687	0.313	0.000
M43.1 Spondylolisthesis	0.687	0.313	0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.685	0.315	0.000
F38 Other mood [affective] disorders	0.684	0.316	0.000
F34 Persistent mood [affective] disorders	0.684	0.316	0.000
F30 Manic episode	0.684	0.316	0.000
F39 Unspecified mood [affective] disorder	0.684	0.316	0.000
R04 Haemorrhage from respiratory passages	0.682	0.318	0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.682	0.318	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.682	0.318	0.000
J09-J18 Influenza and pneumonia	0.681	0.319	0.000
N95 Menopausal and other perimenopausal disorders	0.681	0.319	0.000
N13.7 Vesicoureteral-reflux-associated uropathy	0.681	0.319	0.000
N13.6 Pyonephrosis	0.681	0.319	0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.681	0.319	0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters	0.681	0.319	0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.681	0.319	0.000
M07 Psoriatic and enteropathic arthropathies	0.680	0.320	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.679	0.321	0.000
S82 Fracture of lower leg, including ankle	0.679	0.321	0.000
U80 Agent resistant to penicillin and related antibiotics	0.679	0.321	0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters	0.678	0.322	0.000
M54.5 Low back pain	0.677	0.323	0.000
M20.4 Other hammer toe(s) (acquired)	0.677	0.323	0.000
N98 Complications associated with artificial fertilisation	0.677	0.323	0.000
N82 Fistulae involving female genital tract	0.677	0.323	0.000
N96 Habitual aborter	0.677	0.323	0.000
S50-S59 Injuries to the elbow and forearm	0.676	0.323	0.001
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.675	0.325	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.675	0.325	0.000
M85 Other disorders of bone density and structure	0.674	0.326	0.000
N60.3 Fibrosclerosis of breast	0.674	0.326	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.674	0.326	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.674	0.326	0.000
N97.1 Female infertility of tubal origin	0.674	0.326	0.000
E83 Disorders of mineral metabolism	0.673	0.327	0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters	0.673	0.327	0.000
S62 Fracture at wrist and hand level	0.672	0.327	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.672	0.328	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.672	0.328	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.672	0.328	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.672	0.328	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.672	0.328	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.672	0.328	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.672	0.328	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.672	0.328	0.000
T36 Poisoning by systemic antibiotics	0.672	0.328	0.000
N61 Inflammatory disorders of breast	0.672	0.328	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.671	0.329	0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.671	0.329	0.000
M11 Other crystal arthropathies	0.671	0.329	0.000
M54.22 Cervicalgia (Cervical region)	0.671	0.329	0.000
G99.2 Myelopathy in diseases classified elsewhere	0.670	0.330	0.000
R00 Abnormalities of heart beat	0.670	0.330	0.000
M48.0 Spinal stenosis	0.669	0.330	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.669	0.331	0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.669	0.331	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.669	0.331	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.669	0.331	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.669	0.331	0.000
N94.5 Secondary dysmenorrhoea	0.668	0.332	0.000
N94.4 Primary dysmenorrhoea	0.668	0.332	0.000
N94.3 Premenstrual tension syndrome	0.668	0.332	0.000
N94.2 Vaginismus	0.668	0.332	0.000
N94.0 Mittelschmerz	0.668	0.332	0.000
F01 Vascular dementia	0.668	0.332	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.668	0.332	0.000
D37.7 Other digestive organs	0.668	0.332	0.000
M84 Disorders of continuity of bone	0.667	0.333	0.000
G62 Other polyneuropathies	0.667	0.333	0.000
M75.8 Other shoulder lesions	0.667	0.333	0.000
M75.9 Shoulder lesion, unspecified	0.667	0.333	0.000
D03 Melanoma in situ	0.667	0.333	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.665	0.334	0.000
M41 Scoliosis	0.665	0.335	0.000
B18 Chronic viral hepatitis	0.665	0.335	0.000
S69 Other and unspecified injuries of wrist and hand	0.665	0.335	0.000
S67 Crushing injury of wrist and hand	0.665	0.335	0.000
S65 Injury of blood vessels at wrist and hand level	0.665	0.335	0.000
N85.9 Noninflammatory disorder of uterus, unspecified	0.664	0.335	0.000
H53.8 Other visual disturbances	0.663	0.337	0.000
A49 Bacterial infection of unspecified site	0.662	0.337	0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms	0.662	0.338	0.000
T39.1 4-Aminophenol derivatives	0.662	0.338	0.000
E89.2 Postprocedural hypoparathyroidism	0.661	0.339	0.000
N64.4 Mastodynia	0.660	0.339	0.000
N64.3 Galactorrhoea not associated with childbirth	0.660	0.339	0.000
N64.2 Atrophy of breast	0.660	0.339	0.000
N64.0 Fissure and fistula of nipple	0.660	0.339	0.000
N86 Erosion and ectropion of cervix uteri	0.660	0.340	0.000
N64.8 Other specified disorders of breast	0.660	0.340	0.000
C71 Malignant neoplasm of brain	0.659	0.341	0.000
M25.53 Pain in joint (Forearm)	0.657	0.343	0.000
N25-N29 Other disorders of kidney and ureter	0.657	0.343	0.000
S66.8 Injury of other muscles and tendons at wrist and hand level	0.657	0.343	0.000
H53.1 Subjective visual disturbances	0.657	0.343	0.000
M94 Other disorders of cartilage	0.657	0.343	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.657	0.343	0.000
N21 Calculus of lower urinary tract	0.656	0.344	0.000
N80 Endometriosis	0.656	0.344	0.000
R09.1 Pleurisy	0.656	0.344	0.000
M13.91 Arthritis, unspecified (Shoulder region)	0.655	0.345	0.000
E29 Testicular dysfunction	0.655	0.345	0.000
M53 Other dorsopathies, not elsewhere classified	0.655	0.345	0.000
S20 Superficial injury of thorax	0.655	0.345	0.000
E66.8 Other obesity	0.654	0.346	0.000
N94.9 Unspecified condition associated with female genital organs and menstrual cycle	0.654	0.346	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.653	0.346	0.000
M25.4 Effusion of joint	0.653	0.346	0.000
M23.3 Other meniscus derangements	0.653	0.347	0.000
D46 Myelodysplastic syndromes	0.652	0.348	0.000
S06.5 Traumatic subdural haemorrhage	0.651	0.349	0.000
M79.7 Fibromyalgia	0.651	0.349	0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.651	0.349	0.000
E67 Other hyperalimentation	0.650	0.349	0.000
E68 Sequelae of hyperalimentation	0.650	0.349	0.000
E65 Localised adiposity	0.650	0.349	0.000
M14.6 Neuropathic arthropathy	0.650	0.349	0.000
D37.4 Colon	0.650	0.350	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.650	0.350	0.000
F02 Dementia in other diseases classified elsewhere	0.650	0.350	0.000
F09 Unspecified organic or symptomatic mental disorder	0.650	0.350	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.650	0.350	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.650	0.350	0.000
N85.7 Haematometra	0.649	0.350	0.000
N85.5 Inversion of uterus	0.649	0.350	0.000
N85.3 Subinvolution of uterus	0.649	0.350	0.000
G93 Other disorders of brain	0.649	0.351	0.000
M54.6 Pain in thoracic spine	0.649	0.351	0.000
M25.51 Pain in joint (Shoulder region)	0.649	0.351	0.000
H53.0 Amblyopia ex anopsia	0.648	0.352	0.000
D48.1 Connective and other soft tissue	0.648	0.352	0.000
N92.4 Excessive bleeding in the premenopausal period	0.648	0.352	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.647	0.353	0.000
F40.2 Specific (isolated) phobias	0.647	0.353	0.000
S90-S99 Injuries to the ankle and foot	0.647	0.353	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.647	0.353	0.000
S64.0 Injury of ulnar nerve at wrist and hand level	0.647	0.353	0.000
S80 Superficial injury of lower leg	0.647	0.353	0.000
S60 Superficial injury of wrist and hand	0.646	0.353	0.000
M54.1 Radiculopathy	0.646	0.354	0.000
B34 Viral infection of unspecified site	0.645	0.354	0.000
C50-C50 Malignant neoplasm of breast	0.645	0.354	0.000
F33.8 Other recurrent depressive disorders	0.644	0.356	0.000
F33.4 Recurrent depressive disorder, currently in remission	0.644	0.356	0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms	0.644	0.356	0.000
F33.0 Recurrent depressive disorder, current episode mild	0.644	0.356	0.000
A41.1 Septicaemia due to other specified staphylococcus	0.644	0.356	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.641	0.359	0.000
B17 Other acute viral hepatitis	0.641	0.359	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.640	0.360	0.000
D47.2 Monoclonal gammopathy	0.640	0.360	0.000
S81 Open wound of lower leg	0.639	0.361	0.000
M20.1 Hallux valgus (acquired)	0.639	0.361	0.000
M25.50 Pain in joint (Multiple sites)	0.639	0.361	0.000
Q80-Q89 Other congenital malformations	0.638	0.362	0.000
M49 Spondylopathies in diseases classified elsewhere	0.637	0.363	0.000
D07 Carcinoma in situ of other and unspecified genital organs	0.637	0.363	0.000
B37 Candidiasis	0.637	0.363	0.000
M51.2 Other specified intervertebral disk displacement	0.637	0.363	0.000
S42 Fracture of shoulder and upper arm	0.636	0.364	0.000
E22 Hyperfunction of pituitary gland	0.636	0.364	0.000
S70.9 Superficial injury of hip and thigh, unspecified	0.635	0.365	0.000
M20.3 Other deformity of hallux (acquired)	0.635	0.365	0.000
E88 Other metabolic disorders	0.634	0.366	0.000
D48.0 Bone and articular cartilage	0.634	0.366	0.000
M47.9 Spondylosis, unspecified	0.634	0.366	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.634	0.366	0.000
M24.9 Joint derangement, unspecified	0.633	0.367	0.000
M24.7 Protrusio acetabuli	0.633	0.367	0.000
M24.6 Ankylosis of joint	0.633	0.367	0.000
M24.5 Contracture of joint	0.633	0.367	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.633	0.367	0.000
M24.0 Loose body in joint	0.633	0.367	0.000
M67.8 Other specified disorders of synovium and tendon	0.632	0.368	0.000
D06.9 Cervix, unspecified	0.632	0.368	0.000
E23 Hypofunction and other disorders of pituitary gland	0.632	0.368	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.630	0.370	0.000
F43.0 Acute stress reaction	0.630	0.370	0.000
S64.4 Injury of digital nerve of other finger	0.629	0.371	0.000
N71 Inflammatory disease of uterus, except cervix	0.629	0.371	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.629	0.371	0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.627	0.372	0.000
E34 Other endocrine disorders	0.627	0.372	0.000
C73 Malignant neoplasm of thyroid gland	0.627	0.373	0.000
S79 Other and unspecified injuries of hip and thigh	0.627	0.373	0.000
E66.2 Extreme obesity with alveolar hypoventilation	0.626	0.374	0.000
E66.1 Drug-induced obesity	0.626	0.374	0.000
E66.0 Obesity due to excess calories	0.626	0.374	0.000
M42 Spinal osteochondrosis	0.626	0.374	0.000
M40 Kyphosis and lordosis	0.626	0.374	0.000
M47.8 Other spondylosis	0.625	0.375	0.000
G70-G73 Diseases of myoneural junction and muscle	0.625	0.375	0.000
A48 Other bacterial diseases, not elsewhere classified	0.624	0.376	0.000
A44 Bartonellosis	0.624	0.376	0.000
A43 Nocardiosis	0.624	0.376	0.000
A42 Actinomycosis	0.624	0.376	0.000
A40 Streptococcal septicaemia	0.624	0.376	0.000
A39 Meningococcal infection	0.624	0.376	0.000
A37 Whooping cough	0.624	0.376	0.000
A36 Diphtheria	0.624	0.376	0.000
A32 Listeriosis	0.624	0.376	0.000
A31 Infection due to other mycobacteria	0.624	0.376	0.000
A30 Leprosy [Hansen's disease]	0.624	0.376	0.000
A46 Erysipelas	0.624	0.376	0.000
A38 Scarlet fever	0.624	0.376	0.000
A35 Other tetanus	0.624	0.376	0.000
A34 Obstetrical tetanus	0.624	0.376	0.000
A33 Tetanus neonatorum	0.624	0.376	0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.623	0.376	0.000
C13 Malignant neoplasm of hypopharynx	0.623	0.376	0.000
C11 Malignant neoplasm of nasopharynx	0.623	0.376	0.000
C10 Malignant neoplasm of oropharynx	0.623	0.376	0.000
C08 Malignant neoplasm of other and unspecified major salivary glands	0.623	0.376	0.000
C06 Malignant neoplasm of other and unspecified parts of mouth	0.623	0.376	0.000
C05 Malignant neoplasm of palate	0.623	0.376	0.000
C04 Malignant neoplasm of floor of mouth	0.623	0.376	0.000
C03 Malignant neoplasm of gum	0.623	0.376	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.623	0.376	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations