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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs112458845
log Bayes Factor = 1.1883
Chromosome 3   position 138,675,741  (GRCh37) Explore rs112458845 on Ensembl!
Variant rs112458845 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
0.935 0.065 0.000
Chapter IX Diseases of the circulatory system
0.904 0.096 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.899 0.101 0.000
Chapter X Diseases of the respiratory system
0.897 0.103 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.883 0.117 0.000
J40-J47 Chronic lower respiratory diseases
0.856 0.144 0.000
I20-I25 Ischaemic heart diseases
0.850 0.150 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.849 0.151 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.843 0.157 0.000
Chapter XIV Diseases of the genitourinary system
0.825 0.175 0.000
I30-I52 Other forms of heart disease
0.803 0.197 0.000
R42 Dizziness and giddiness
0.802 0.198 0.000
J45 Asthma
0.794 0.206 0.000
I25 Chronic ischaemic heart disease
0.794 0.206 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.782 0.218 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.781 0.219 0.000
Chapter XX External causes of morbidity and mortality
0.762 0.238 0.000
E70-E90 Metabolic disorders
0.761 0.239 0.000
M20-M25 Other joint disorders
0.755 0.245 0.000
M05-M14 Inflammatory polyarthropathies
0.752 0.248 0.000
J45.9 Asthma, unspecified
0.750 0.250 0.000
Chapter VI Diseases of the nervous system
0.749 0.251 0.000
Chapter VII Diseases of the eye and adnexa
0.738 0.262 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.737 0.263 0.000
M70-M79 Other soft tissue disorders
0.735 0.265 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.728 0.272 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.725 0.275 0.000
E10-E14 Diabetes mellitus
0.721 0.279 0.000
J95-J99 Other diseases of the respiratory system
0.716 0.284 0.000
I05-I09 Chronic rheumatic heart diseases
0.715 0.285 0.000
Chapter II Neoplasms
0.709 0.291 0.000
I25.1 Atherosclerotic heart disease
0.705 0.295 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.705 0.295 0.000
J20-J22 Other acute lower respiratory infections
0.705 0.295 0.000
I20 Angina pectoris
0.698 0.302 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.695 0.305 0.000
Chapter VIII Diseases of the ear and mastoid process
0.693 0.307 0.000
J47 Bronchiectasis
0.691 0.309 0.000
M65-M68 Disorders of synovium and tendon
0.691 0.309 0.000
M50-M54 Other dorsopathies
0.687 0.313 0.000
I50 Heart failure
0.687 0.313 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.687 0.313 0.000
N17-N19 Renal failure
0.683 0.317 0.000
J44 Other chronic obstructive pulmonary disease
0.670 0.330 0.000
Chapter XXII Codes for special purposes
0.670 0.330 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.670 0.330 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.670 0.330 0.000
Chapter I Certain infectious and parasitic diseases
0.669 0.331 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.667 0.332 0.000
M45-M49 Spondylopathies
0.667 0.333 0.000
I60-I69 Cerebrovascular diseases
0.667 0.333 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.666 0.334 0.000
R10 Abdominal and pelvic pain
0.665 0.335 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.657 0.342 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.654 0.346 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.654 0.346 0.000
M06 Other rheumatoid arthritis
0.654 0.346 0.000
R00 Abnormalities of heart beat
0.651 0.349 0.000
I47 Paroxysmal tachycardia
0.651 0.349 0.000
I00-I02 Acute rheumatic fever
0.648 0.352 0.000
N30-N39 Other diseases of urinary system
0.647 0.353 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.645 0.355 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.645 0.355 0.000
R47-R49 Symptoms and signs involving speech and voice
0.645 0.355 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.643 0.357 0.000
J60-J70 Lung diseases due to external agents
0.643 0.357 0.000
J00-J06 Acute upper respiratory infections
0.643 0.357 0.000
R17 Unspecified jaundice
0.640 0.360 0.000
E86 Volume depletion
0.640 0.360 0.000
J90-J94 Other diseases of pleura
0.639 0.361 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.638 0.362 0.000
I25.2 Old myocardial infarction
0.638 0.362 0.000
J43 Emphysema
0.635 0.365 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.635 0.365 0.000
M75 Shoulder lesions
0.635 0.365 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.633 0.367 0.000
M91-M94 Chondropathies
0.633 0.367 0.000
M86-M90 Other osteopathies
0.633 0.367 0.000
M60-M63 Disorders of muscles
0.633 0.367 0.000
M40-M43 Deforming dorsopathies
0.633 0.367 0.000
M00-M03 Infectious arthropathies
0.633 0.367 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.629 0.371 0.000
M20 Acquired deformities of fingers and toes
0.627 0.373 0.000
R11 Nausea and vomiting
0.624 0.376 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.622 0.378 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.620 0.380 0.000
R10.2 Pelvic and perineal pain
0.618 0.382 0.000
M80-M85 Disorders of bone density and structure
0.614 0.386 0.000
J41 Simple and mucopurulent chronic bronchitis
0.614 0.386 0.000
J46 Status asthmaticus
0.614 0.386 0.000
J42 Unspecified chronic bronchitis
0.614 0.386 0.000
J40 Bronchitis, not specified as acute or chronic
0.614 0.386 0.000
G90-G99 Other disorders of the nervous system
0.611 0.389 0.000
M25 Other joint disorders, not elsewhere classified
0.610 0.390 0.000
I24 Other acute ischaemic heart diseases
0.609 0.390 0.000
I23 Certain current complications following acute myocardial infarction
0.609 0.390 0.000
I22 Subsequent myocardial infarction
0.609 0.390 0.000
R07 Pain in throat and chest
0.609 0.390 0.000
E50-E64 Other nutritional deficiencies
0.609 0.391 0.000
E40-E46 Malnutrition
0.609 0.391 0.000
E20-E35 Disorders of other endocrine glands
0.609 0.391 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.609 0.391 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.609 0.391 0.000
N95 Menopausal and other perimenopausal disorders
0.608 0.392 0.000
R46 Symptoms and signs involving appearance and behaviour
0.604 0.395 0.000
R45 Symptoms and signs involving emotional state
0.604 0.395 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.604 0.395 0.000
R43 Disturbances of smell and taste
0.604 0.395 0.000
R40 Somnolence, stupor and coma
0.604 0.395 0.000
E65-E68 Obesity and other hyperalimentation
0.604 0.396 0.000
J09-J18 Influenza and pneumonia
0.603 0.397 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.597 0.403 0.000
R05 Cough
0.597 0.403 0.000
I73 Other peripheral vascular diseases
0.596 0.404 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.595 0.405 0.000
N60-N64 Disorders of breast
0.594 0.405 0.000
N40-N51 Diseases of male genital organs
0.594 0.406 0.000
E11 Non-insulin-dependent diabetes mellitus
0.594 0.406 0.000
I51 Complications and ill-defined descriptions of heart disease
0.591 0.408 0.000
N99-N99 Other disorders of the genitourinary system
0.591 0.409 0.000
N25-N29 Other disorders of kidney and ureter
0.591 0.409 0.000
N10-N16 Renal tubulo-interstitial diseases
0.591 0.409 0.000
N00-N08 Glomerular diseases
0.591 0.409 0.000
R15 Faecal incontinence
0.591 0.409 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.589 0.411 0.000
N20-N23 Urolithiasis
0.588 0.412 0.000
J98 Other respiratory disorders
0.587 0.413 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.587 0.413 0.000
I21 Acute myocardial infarction
0.587 0.413 0.000
Chapter V Mental and behavioural disorders
0.586 0.414 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.584 0.416 0.000
M06.9 Rheumatoid arthritis, unspecified
0.584 0.416 0.000
I08 Multiple valve diseases
0.580 0.420 0.000
I10-I15 Hypertensive diseases
0.580 0.420 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.577 0.423 0.000
I52 Other heart disorders in diseases classified elsewhere
0.576 0.424 0.000
I49 Other cardiac arrhythmias
0.576 0.424 0.000
I48 Atrial fibrillation and flutter
0.576 0.424 0.000
I46 Cardiac arrest
0.576 0.424 0.000
I45 Other conduction disorders
0.576 0.424 0.000
I44 Atrioventricular and left bundle-branch block
0.576 0.424 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.576 0.424 0.000
I42 Cardiomyopathy
0.576 0.424 0.000
I41 Myocarditis in diseases classified elsewhere
0.576 0.424 0.000
I40 Acute myocarditis
0.576 0.424 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.576 0.424 0.000
I37 Pulmonary valve disorders
0.576 0.424 0.000
I36 Nonrheumatic tricuspid valve disorders
0.576 0.424 0.000
I35 Nonrheumatic aortic valve disorders
0.576 0.424 0.000
I34 Nonrheumatic mitral valve disorders
0.576 0.424 0.000
I33 Acute and subacute endocarditis
0.576 0.424 0.000
I32 Pericarditis in diseases classified elsewhere
0.576 0.424 0.000
I31 Other diseases of pericardium
0.576 0.424 0.000
I30 Acute pericarditis
0.576 0.424 0.000
I38 Endocarditis, valve unspecified
0.576 0.424 0.000
J30-J39 Other diseases of upper respiratory tract
0.575 0.425 0.000
E14 Unspecified diabetes mellitus
0.573 0.427 0.000
I50.9 Heart failure, unspecified
0.571 0.429 0.000
N18 Chronic renal failure
0.570 0.430 0.000
J45.8 Mixed asthma
0.569 0.430 0.000
J45.1 Nonallergic asthma
0.569 0.430 0.000
J45.0 Predominantly allergic asthma
0.569 0.430 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.569 0.430 0.000
I25.6 Silent myocardial ischaemia
0.569 0.431 0.000
I25.5 Ischaemic cardiomyopathy
0.569 0.431 0.000
I25.4 Coronary artery aneurysm
0.569 0.431 0.000
I25.3 Aneurysm of heart
0.569 0.431 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.569 0.431 0.000
I20.9 Angina pectoris, unspecified
0.567 0.433 0.000
J22 Unspecified acute lower respiratory infection
0.567 0.433 0.000
R00.2 Palpitations
0.564 0.436 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.562 0.438 0.000
M75.4 Impingement syndrome of shoulder
0.562 0.438 0.000
G40-G47 Episodic and paroxysmal disorders
0.561 0.439 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.561 0.439 0.000
R18 Ascites
0.561 0.439 0.000
R14 Flatulence and related conditions
0.561 0.439 0.000
R12 Heartburn
0.561 0.439 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.560 0.440 0.000
R04 Haemorrhage from respiratory passages
0.560 0.440 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.560 0.440 0.000
R01 Cardiac murmurs and other cardiac sounds
0.560 0.440 0.000
R02 Gangrene, not elsewhere classified
0.560 0.440 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.558 0.442 0.000
R06 Abnormalities of breathing
0.558 0.442 0.000
N83 Noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.557 0.443 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.557 0.443 0.000
N95.0 Postmenopausal bleeding
0.556 0.444 0.000
R19 Other symptoms and signs involving the digestive system and abdomen
0.556 0.444 0.000
M67 Other disorders of synovium and tendon
0.554 0.446 0.000
M54 Dorsalgia
0.551 0.449 0.000
S80-S89 Injuries to the knee and lower leg
0.549 0.451 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.549 0.451 0.000
W00-W19 Falls
0.549 0.451 0.000
M13 Other arthritis
0.548 0.452 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.547 0.453 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.547 0.453 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.547 0.453 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.547 0.453 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.547 0.453 0.000
Y35-Y36 Legal intervention and operations of war
0.547 0.453 0.000
Y10-Y34 Event of undetermined intent
0.547 0.453 0.000
Y00-Y09 Assault
0.547 0.453 0.000
X85-X99 Assault
0.547 0.453 0.000
X60-X84 Intentional self-harm
0.547 0.453 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.547 0.453 0.000
X50-X57 Overexertion, travel and privation
0.547 0.453 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.547 0.453 0.000
X30-X39 Exposure to forces of nature
0.547 0.453 0.000
X20-X29 Contact with venomous animals and plants
0.547 0.453 0.000
X10-X19 Contact with heat and hot substances
0.547 0.453 0.000
X00-X09 Exposure to smoke, fire and flames
0.547 0.453 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.547 0.453 0.000
W75-W84 Other accidental threats to breathing
0.547 0.453 0.000
W65-W74 Accidental drowning and submersion
0.547 0.453 0.000
W50-W64 Exposure to animate mechanical forces
0.547 0.453 0.000
W20-W49 Exposure to inanimate mechanical forces
0.547 0.453 0.000
V98-V99 Other and unspecified transport accidents
0.547 0.453 0.000
V95-V97 Air and space transport accidents
0.547 0.453 0.000
V90-V94 Water transport accidents
0.547 0.453 0.000
V80-V89 Other land transport accidents
0.547 0.453 0.000
V70-V79 Bus occupant injured in transport accident
0.547 0.453 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.547 0.453 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.547 0.453 0.000
V40-V49 Car occupant injured in transport accident
0.547 0.453 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.547 0.453 0.000
V20-V29 Motorcycle rider injured in transport accident
0.547 0.453 0.000
V10-V19 Pedal cyclist injured in transport accident
0.547 0.453 0.000
V01-V09 Pedestrian injured in transport accident
0.547 0.453 0.000
I50.0 Congestive heart failure
0.546 0.453 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.546 0.454 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.546 0.454 0.000
E88 Other metabolic disorders
0.546 0.454 0.000
E85 Amyloidosis
0.546 0.454 0.000
E84 Cystic fibrosis
0.546 0.454 0.000
E83 Disorders of mineral metabolism
0.546 0.454 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.546 0.454 0.000
E79 Disorders of purine and pyrimidine metabolism
0.546 0.454 0.000
E77 Disorders of glycoprotein metabolism
0.546 0.454 0.000
E76 Disorders of glycosaminoglycan metabolism
0.546 0.454 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.546 0.454 0.000
E74 Other disorders of carbohydrate metabolism
0.546 0.454 0.000
E73 Lactose intolerance
0.546 0.454 0.000
E72 Other disorders of amino-acid metabolism
0.546 0.454 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.546 0.454 0.000
E70 Disorders of aromatic amino-acid metabolism
0.546 0.454 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.546 0.454 0.000
E00-E07 Disorders of thyroid gland
0.546 0.454 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.546 0.454 0.000
C64-C68 Malignant neoplasms of urinary tract
0.545 0.455 0.000
Chapter XI Diseases of the digestive system
0.543 0.457 0.000
S70-S79 Injuries to the hip and thigh
0.542 0.458 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.542 0.458 0.000
I47.1 Supraventricular tachycardia
0.542 0.458 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.541 0.459 0.000
M35 Other systemic involvement of connective tissue
0.541 0.459 0.000
M34 Systemic sclerosis
0.541 0.459 0.000
M33 Dermatopolymyositis
0.541 0.459 0.000
M32 Systemic lupus erythematosus
0.541 0.459 0.000
M31 Other necrotising vasculopathies
0.541 0.459 0.000
M30 Polyarteritis nodosa and related conditions
0.541 0.459 0.000
M24 Other specific joint derangements
0.541 0.459 0.000
M22 Disorders of patella
0.541 0.459 0.000
M21 Other acquired deformities of limbs
0.541 0.459 0.000
H30-H36 Disorders of choroid and retina
0.539 0.460 0.000
M14 Arthropathies in other diseases classified elsewhere
0.539 0.461 0.000
M12 Other specific arthropathies
0.539 0.461 0.000
M11 Other crystal arthropathies
0.539 0.461 0.000
M10 Gout
0.539 0.461 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.539 0.461 0.000
M08 Juvenile arthritis
0.539 0.461 0.000
M07 Psoriatic and enteropathic arthropathies
0.539 0.461 0.000
M05 Seropositive rheumatoid arthritis
0.539 0.461 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.537 0.463 0.000
G70-G73 Diseases of myoneural junction and muscle
0.537 0.463 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.537 0.463 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.537 0.463 0.000
G30-G32 Other degenerative diseases of the nervous system
0.537 0.463 0.000
G20-G26 Extrapyramidal and movement disorders
0.537 0.463 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.537 0.463 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.537 0.463 0.000
J84 Other interstitial pulmonary diseases
0.536 0.464 0.000
D00-D09 In situ neoplasms
0.536 0.464 0.000
H25-H28 Disorders of lens
0.535 0.465 0.000
R07.3 Other chest pain
0.534 0.466 0.000
C15-C26 Malignant neoplasms of digestive organs
0.534 0.466 0.000
I20.0 Unstable angina
0.533 0.466 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.533 0.467 0.000
M72 Fibroblastic disorders
0.530 0.470 0.000
L60-L75 Disorders of skin appendages
0.530 0.470 0.000
D10-D36 Benign neoplasms
0.530 0.470 0.000
R30-R39 Symptoms and signs involving the urinary system
0.529 0.470 0.000
H55-H59 Other disorders of eye and adnexa
0.529 0.471 0.000
H53-H54 Visual disturbances and blindness
0.529 0.471 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.529 0.471 0.000
H43-H45 Disorders of vitreous body and globe
0.529 0.471 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.529 0.471 0.000
H10-H13 Disorders of conjunctiva
0.529 0.471 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.529 0.471 0.000
T79-T79 Certain early complications of trauma
0.529 0.471 0.000
T66-T78 Other and unspecified effects of external causes
0.529 0.471 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.529 0.471 0.000
T33-T35 Frostbite
0.529 0.471 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.529 0.471 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.529 0.471 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.529 0.471 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.529 0.471 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.529 0.471 0.000
T00-T07 Injuries involving multiple body regions
0.529 0.471 0.000
S90-S99 Injuries to the ankle and foot
0.529 0.471 0.000
S60-S69 Injuries to the wrist and hand
0.529 0.471 0.000
S40-S49 Injuries to the shoulder and upper arm
0.529 0.471 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.529 0.471 0.000
S20-S29 Injuries to the thorax
0.529 0.471 0.000
S10-S19 Injuries to the neck
0.529 0.471 0.000
M23 Internal derangement of knee
0.527 0.472 0.000
N19 Unspecified renal failure
0.527 0.473 0.000
M77 Other enthesopathies
0.527 0.473 0.000
M76 Enthesopathies of lower limb, excluding foot
0.527 0.473 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.527 0.473 0.000
M71 Other bursopathies
0.527 0.473 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.527 0.473 0.000
N35 Urethral stricture
0.524 0.476 0.000
N32 Other disorders of bladder
0.524 0.476 0.000
B35-B49 Mycoses
0.524 0.476 0.000
L50-L54 Urticaria and erythema
0.522 0.478 0.000
L40-L45 Papulosquamous disorders
0.522 0.478 0.000
L20-L30 Dermatitis and eczema
0.522 0.478 0.000
L10-L14 Bullous disorders
0.522 0.478 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.522 0.478 0.000
S00-S09 Injuries to the head
0.521 0.479 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.521 0.479 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.520 0.480 0.000
I78 Diseases of capillaries
0.520 0.480 0.000
I77 Other disorders of arteries and arterioles
0.520 0.480 0.000
I74 Arterial embolism and thrombosis
0.520 0.480 0.000
I72 Other aneurysm
0.520 0.480 0.000
I71 Aortic aneurysm and dissection
0.520 0.480 0.000
I70 Atherosclerosis
0.520 0.480 0.000
H90-H95 Other disorders of ear
0.519 0.480 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.519 0.481 0.000
E13 Other specified diabetes mellitus
0.517 0.483 0.000
E12 Malnutrition-related diabetes mellitus
0.517 0.483 0.000
E10 Insulin-dependent diabetes mellitus
0.517 0.483 0.000
S50-S59 Injuries to the elbow and forearm
0.515 0.485 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.514 0.486 0.000
J96 Respiratory failure, not elsewhere classified
0.514 0.486 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.514 0.486 0.000
I09 Other rheumatic heart diseases
0.513 0.487 0.000
I07 Rheumatic tricuspid valve diseases
0.513 0.487 0.000
I06 Rheumatic aortic valve diseases
0.513 0.487 0.000
I05 Rheumatic mitral valve diseases
0.513 0.487 0.000
M47 Spondylosis
0.513 0.487 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.512 0.488 0.000
G93 Other disorders of brain
0.511 0.489 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.511 0.489 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.508 0.492 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.508 0.492 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.508 0.492 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.508 0.492 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.508 0.492 0.000
C51-C58 Malignant neoplasms of female genital organs
0.508 0.492 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.508 0.492 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.508 0.492 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.508 0.492 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.508 0.492 0.000
R94 Abnormal results of function studies
0.507 0.493 0.000
M25.5 Pain in joint
0.506 0.494 0.000
Y83.6 Removal of other organ (partial) (total)
0.506 0.494 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.505 0.494 0.000
O85-O92 Complications predominantly related to the puerperium
0.505 0.494 0.000
O80-O84 Delivery
0.505 0.494 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.505 0.494 0.000
O00-O08 Pregnancy with abortive outcome
0.505 0.494 0.000
J21 Acute bronchiolitis
0.505 0.495 0.000
J20 Acute bronchitis
0.505 0.495 0.000
I73.9 Peripheral vascular disease, unspecified
0.504 0.496 0.000
C50-C50 Malignant neoplasm of breast
0.503 0.496 0.000
E11.9 Without complications
0.503 0.497 0.000
H40-H42 Glaucoma
0.503 0.497 0.000
R79 Other abnormal findings of blood chemistry
0.501 0.499 0.000
I20.8 Other forms of angina pectoris
0.500 0.499 0.000
I20.1 Angina pectoris with documented spasm
0.500 0.499 0.000
M20.1 Hallux valgus (acquired)
0.500 0.500 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.498 0.501 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.498 0.501 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.498 0.501 0.000
I63 Cerebral infarction
0.497 0.503 0.000
H80-H83 Diseases of inner ear
0.497 0.503 0.000
H65-H75 Diseases of middle ear and mastoid
0.497 0.503 0.000
H60-H62 Diseases of external ear
0.497 0.503 0.000
O60-O75 Complications of labour and delivery
0.497 0.503 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.495 0.504 0.000
M66 Spontaneous rupture of synovium and tendon
0.495 0.504 0.000
M65 Synovitis and tenosynovitis
0.495 0.504 0.000
J98.1 Pulmonary collapse
0.494 0.505 0.000
I50.1 Left ventricular failure
0.494 0.506 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.494 0.506 0.000
M53 Other dorsopathies, not elsewhere classified
0.493 0.507 0.000
M50 Cervical disk disorders
0.493 0.507 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.492 0.508 0.000
J81 Pulmonary oedema
0.492 0.508 0.000
J80 Adult respiratory distress syndrome
0.492 0.508 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.491 0.509 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.490 0.510 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.490 0.510 0.000
E87.5 Hyperkalaemia
0.489 0.511 0.000
M51 Other intervertebral disk disorders
0.487 0.512 0.000
R87 Abnormal findings in specimens from female genital organs
0.484 0.516 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.483 0.517 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.481 0.519 0.000
P90-P96 Other disorders originating in the perinatal period
0.480 0.519 0.000
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn
0.480 0.519 0.000
P75-P78 Digestive system disorders of fetus and newborn
0.480 0.519 0.000
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn
0.480 0.519 0.000
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn
0.480 0.519 0.000
P35-P39 Infections specific to the perinatal period
0.480 0.519 0.000
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period
0.480 0.519 0.000
P10-P15 Birth trauma
0.480 0.519 0.000
P05-P08 Disorders related to length of gestation and fetal growth
0.480 0.519 0.000
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
0.480 0.519 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.480 0.519 0.000
Q80-Q89 Other congenital malformations
0.480 0.519 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.480 0.519 0.000
Q60-Q64 Congenital malformations of the urinary system
0.480 0.519 0.000
Q50-Q56 Congenital malformations of genital organs
0.480 0.519 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.480 0.519 0.000
Q35-Q37 Cleft lip and cleft palate
0.480 0.519 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.480 0.519 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.480 0.519 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.480 0.519 0.000
Q00-Q07 Congenital malformations of the nervous system
0.480 0.519 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.480 0.519 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.480 0.519 0.000
B99-B99 Other infectious diseases
0.480 0.520 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.480 0.520 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.480 0.520 0.000
B65-B83 Helminthiases
0.480 0.520 0.000
B50-B64 Protozoal diseases
0.480 0.520 0.000
B25-B34 Other viral diseases
0.480 0.520 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.480 0.520 0.000
B15-B19 Viral hepatitis
0.480 0.520 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.480 0.520 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.480 0.520 0.000
A80-A89 Viral infections of the central nervous system
0.480 0.520 0.000
A75-A79 Rickettsioses
0.480 0.520 0.000
A70-A74 Other diseases caused by chlamydiae
0.480 0.520 0.000
A65-A69 Other spirochaetal diseases
0.480 0.520 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.480 0.520 0.000
A20-A28 Certain zoonotic bacterial diseases
0.480 0.520 0.000
A15-A19 Tuberculosis
0.480 0.520 0.000
N83.2 Other and unspecified ovarian cysts
0.479 0.521 0.000
M20.5 Other deformities of toe(s) (acquired)
0.479 0.521 0.000
R78 Findings of drugs and other substances, not normally found in blood
0.479 0.521 0.000
R77 Other abnormalities of plasma proteins
0.479 0.521 0.000
R76 Other abnormal immunological findings in serum
0.479 0.521 0.000
R74 Abnormal serum enzyme levels
0.479 0.521 0.000
R73 Elevated blood glucose level
0.479 0.521 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.479 0.521 0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]
0.479 0.521 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.479 0.521 0.000
R71 Abnormality of red blood cells
0.479 0.521 0.000
R26 Abnormalities of gait and mobility
0.478 0.521 0.000
M49 Spondylopathies in diseases classified elsewhere
0.478 0.522 0.000
M48 Other spondylopathies
0.478 0.522 0.000
M46 Other inflammatory spondylopathies
0.478 0.522 0.000
M45 Ankylosing spondylitis
0.478 0.522 0.000
I69 Sequelae of cerebrovascular disease
0.478 0.522 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.478 0.522 0.000
I67 Other cerebrovascular diseases
0.478 0.522 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.478 0.522 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.478 0.522 0.000
I62 Other nontraumatic intracranial haemorrhage
0.478 0.522 0.000
I61 Intracerebral haemorrhage
0.478 0.522 0.000
I60 Subarachnoid haemorrhage
0.478 0.522 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.478 0.522 0.000
R21 Rash and other nonspecific skin eruption
0.478 0.522 0.000
N98 Complications associated with artificial fertilisation
0.478 0.522 0.000
N97 Female infertility
0.478 0.522 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.478 0.522 0.000
N93 Other abnormal uterine and vaginal bleeding
0.478 0.522 0.000
N91 Absent, scanty and rare menstruation
0.478 0.522 0.000
N90 Other noninflammatory disorders of vulva and perineum
0.478 0.522 0.000
N89 Other noninflammatory disorders of vagina
0.478 0.522 0.000
N88 Other noninflammatory disorders of cervix uteri
0.478 0.522 0.000
N87 Dysplasia of cervix uteri
0.478 0.522 0.000
N82 Fistulae involving female genital tract
0.478 0.522 0.000
N80 Endometriosis
0.478 0.522 0.000
N96 Habitual aborter
0.478 0.522 0.000
N86 Erosion and ectropion of cervix uteri
0.478 0.522 0.000
J43.9 Emphysema, unspecified
0.477 0.523 0.000
R10.0 Acute abdomen
0.477 0.523 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.477 0.523 0.000
M20.2 Hallux rigidus
0.475 0.525 0.000
N95.2 Postmenopausal atrophic vaginitis
0.472 0.528 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.471 0.528 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.471 0.528 0.000
R86 Abnormal findings in specimens from male genital organs
0.471 0.528 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.471 0.528 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.471 0.528 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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