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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs117453948
log Bayes Factor = 17.5477
Chromosome 16   position 77,965,459  (GRCh37) Explore rs117453948 on Ensembl!
Variant rs117453948 is part of Cluster X0042

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.999 0.001 0.000
I30-I52 Other forms of heart disease
0.998 0.002 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.997 0.003 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.996 0.004 0.000
Chapter XX External causes of morbidity and mortality
0.995 0.005 0.000
M50-M54 Other dorsopathies
0.987 0.013 0.000
I50 Heart failure
0.981 0.019 0.000
Chapter XXI Factors influencing health status and contact with health services
0.980 0.020 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.980 0.020 0.000
M54 Dorsalgia
0.975 0.025 0.000
Chapter VII Diseases of the eye and adnexa
0.972 0.028 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.968 0.032 0.000
M54.5 Low back pain
0.965 0.035 0.000
I50.0 Congestive heart failure
0.965 0.035 0.000
C79 Secondary malignant neoplasm of other sites
0.964 0.036 0.000
S00-S09 Injuries to the head
0.964 0.036 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.963 0.037 0.000
R50-R69 General symptoms and signs
0.955 0.045 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.951 0.049 0.000
R51 Headache
0.949 0.051 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.946 0.054 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.944 0.056 0.000
M20-M25 Other joint disorders
0.942 0.058 0.000
I05-I09 Chronic rheumatic heart diseases
0.938 0.062 0.000
C78.7 Secondary malignant neoplasm of liver
0.937 0.063 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.934 0.066 0.000
M54.59 Low back pain (Site unspecified)
0.929 0.071 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.922 0.078 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.920 0.080 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.918 0.082 0.000
Chapter VIII Diseases of the ear and mastoid process
0.917 0.083 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.915 0.085 0.000
C77.2 Intra-abdominal lymph nodes
0.913 0.087 0.000
R42 Dizziness and giddiness
0.912 0.088 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.911 0.089 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.907 0.093 0.000
D70 Agranulocytosis
0.904 0.096 0.000
I42 Cardiomyopathy
0.903 0.097 0.000
R30-R39 Symptoms and signs involving the urinary system
0.902 0.098 0.000
C78.0 Secondary malignant neoplasm of lung
0.900 0.100 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.900 0.100 0.000
Z85 Personal history of malignant neoplasm
0.893 0.107 0.000
M25 Other joint disorders, not elsewhere classified
0.892 0.108 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.890 0.110 0.000
I51 Complications and ill-defined descriptions of heart disease
0.889 0.111 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.889 0.111 0.000
S20-S29 Injuries to the thorax
0.887 0.113 0.000
I50.9 Heart failure, unspecified
0.886 0.114 0.000
W00-W19 Falls
0.885 0.115 0.000
Chapter I Certain infectious and parasitic diseases
0.885 0.115 0.000
I87 Other disorders of veins
0.884 0.116 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.883 0.117 0.000
M22 Disorders of patella
0.880 0.120 0.000
H30-H36 Disorders of choroid and retina
0.879 0.121 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.878 0.122 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.877 0.123 0.000
M51 Other intervertebral disk disorders
0.866 0.134 0.000
I80 Phlebitis and thrombophlebitis
0.866 0.134 0.000
H53-H54 Visual disturbances and blindness
0.865 0.135 0.000
S80-S89 Injuries to the knee and lower leg
0.863 0.137 0.000
H40-H42 Glaucoma
0.863 0.137 0.000
R35 Polyuria
0.861 0.139 0.000
Chapter X Diseases of the respiratory system
0.861 0.139 0.000
I08 Multiple valve diseases
0.861 0.139 0.000
M45-M49 Spondylopathies
0.857 0.143 0.000
S09 Other and unspecified injuries of head
0.854 0.146 0.000
C77.5 Intrapelvic lymph nodes
0.853 0.147 0.000
Z85.6 Personal history of leukaemia
0.847 0.153 0.000
T39.1 4-Aminophenol derivatives
0.847 0.153 0.000
T43.2 Other and unspecified antidepressants
0.845 0.155 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.844 0.156 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.844 0.156 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.844 0.156 0.000
M54.57 Low back pain (Lumbosacral region)
0.842 0.158 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.839 0.161 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.839 0.161 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.836 0.164 0.000
M91-M94 Chondropathies
0.834 0.166 0.000
I44 Atrioventricular and left bundle-branch block
0.833 0.167 0.000
Z91.5 Personal history of self-harm
0.831 0.169 0.000
M25.7 Osteophyte
0.827 0.173 0.000
I34 Nonrheumatic mitral valve disorders
0.827 0.173 0.000
Z96 Presence of other functional implants
0.826 0.174 0.000
R32 Unspecified urinary incontinence
0.825 0.175 0.000
W20-W49 Exposure to inanimate mechanical forces
0.823 0.177 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.822 0.178 0.000
S01 Open wound of head
0.821 0.179 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.821 0.179 0.000
I51.9 Heart disease, unspecified
0.821 0.179 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.821 0.179 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.818 0.182 0.000
R26 Abnormalities of gait and mobility
0.817 0.183 0.000
Z85.1 Personal history of malignant neoplasm of trachea, bronchus and lung
0.817 0.183 0.000
Z83 Family history of other specific disorders
0.816 0.184 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.816 0.184 0.000
M54.56 Low back pain (Lumbar region)
0.815 0.185 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.810 0.190 0.000
H33 Retinal detachments and breaks
0.809 0.191 0.000
S06 Intracranial injury
0.809 0.191 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.808 0.192 0.000
Z60 Problems related to social environment
0.807 0.193 0.000
W19 Unspecified fall
0.807 0.193 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.806 0.194 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.806 0.194 0.000
H10-H13 Disorders of conjunctiva
0.806 0.194 0.000
Z92 Personal history of medical treatment
0.803 0.197 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.803 0.197 0.000
J90-J94 Other diseases of pleura
0.803 0.197 0.000
I47 Paroxysmal tachycardia
0.802 0.197 0.000
I85 Oesophageal varices
0.801 0.199 0.000
R06 Abnormalities of breathing
0.801 0.199 0.000
Z94 Transplanted organ and tissue status
0.801 0.199 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.798 0.202 0.000
M54.2 Cervicalgia
0.798 0.202 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.797 0.202 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.797 0.203 0.000
H65-H75 Diseases of middle ear and mastoid
0.797 0.203 0.000
Chapter XXII Codes for special purposes
0.796 0.204 0.000
M80-M85 Disorders of bone density and structure
0.793 0.207 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.791 0.209 0.000
S70-S79 Injuries to the hip and thigh
0.791 0.209 0.000
Y43 Primarily systemic agents
0.790 0.210 0.000
R00 Abnormalities of heart beat
0.790 0.210 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.790 0.210 0.000
Chapter VI Diseases of the nervous system
0.790 0.210 0.000
X60-X84 Intentional self-harm
0.787 0.213 0.000
R06.0 Dyspnoea
0.786 0.214 0.000
H40 Glaucoma
0.785 0.215 0.000
H53 Visual disturbances
0.784 0.216 0.000
M25.77 Osteophyte (Ankle and foot)
0.783 0.217 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.783 0.217 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.783 0.217 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.781 0.219 0.000
Chapter V Mental and behavioural disorders
0.781 0.219 0.000
I87.8 Other specified disorders of veins
0.781 0.219 0.000
M47 Spondylosis
0.779 0.221 0.000
R52 Pain, not elsewhere classified
0.779 0.221 0.000
C77.0 Lymph nodes of head, face and neck
0.777 0.223 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.776 0.224 0.000
S09.9 Unspecified injury of head
0.776 0.224 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.775 0.225 0.000
R93.4 Abnormal findings on diagnostic imaging of urinary organs
0.772 0.228 0.000
B25-B34 Other viral diseases
0.771 0.229 0.000
R60 Oedema, not elsewhere classified
0.769 0.231 0.000
M51.2 Other specified intervertebral disk displacement
0.769 0.231 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.769 0.231 0.000
Z51 Other medical care
0.769 0.231 0.000
I42.0 Dilated cardiomyopathy
0.768 0.232 0.000
I27 Other pulmonary heart diseases
0.767 0.233 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.766 0.234 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.766 0.234 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.765 0.235 0.000
C50-C50 Malignant neoplasm of breast
0.763 0.237 0.000
I05 Rheumatic mitral valve diseases
0.762 0.238 0.000
M22.2 Patellofemoral disorders
0.762 0.238 0.000
Z48 Other surgical follow-up care
0.762 0.238 0.000
M25.4 Effusion of joint
0.761 0.239 0.000
I86 Varicose veins of other sites
0.761 0.239 0.000
Z97 Presence of other devices
0.760 0.240 0.000
R00.1 Bradycardia, unspecified
0.759 0.241 0.000
I08.0 Disorders of both mitral and aortic valves
0.757 0.243 0.000
S40-S49 Injuries to the shoulder and upper arm
0.757 0.243 0.000
Z60.2 Living alone
0.756 0.244 0.000
R25 Abnormal involuntary movements
0.753 0.246 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.752 0.248 0.000
I30 Acute pericarditis
0.752 0.248 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.752 0.248 0.000
Z98 Other postsurgical states
0.751 0.249 0.000
C64-C68 Malignant neoplasms of urinary tract
0.751 0.249 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.751 0.249 0.000
S50-S59 Injuries to the elbow and forearm
0.751 0.249 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.751 0.249 0.000
S20 Superficial injury of thorax
0.750 0.250 0.000
D75 Other diseases of blood and blood-forming organs
0.750 0.250 0.000
Z51.5 Palliative care
0.749 0.251 0.000
S00 Superficial injury of head
0.749 0.251 0.000
S10-S19 Injuries to the neck
0.749 0.251 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.749 0.251 0.000
C80 Malignant neoplasm without specification of site
0.748 0.252 0.000
H90-H95 Other disorders of ear
0.747 0.253 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.744 0.256 0.000
R57 Shock, not elsewhere classified
0.743 0.256 0.000
M22.8 Other disorders of patella
0.743 0.257 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.743 0.257 0.000
I34.0 Mitral (valve) insufficiency
0.743 0.257 0.000
Z95.4 Presence of other heart-valve replacement
0.743 0.257 0.000
Z51.8 Other specified medical care
0.743 0.257 0.000
I31 Other diseases of pericardium
0.743 0.257 0.000
R45 Symptoms and signs involving emotional state
0.742 0.257 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.742 0.258 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.741 0.259 0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.740 0.260 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.740 0.260 0.000
C78.2 Secondary malignant neoplasm of pleura
0.738 0.262 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.737 0.263 0.000
T40.2 Other opioids
0.736 0.264 0.000
C79.2 Secondary malignant neoplasm of skin
0.735 0.264 0.000
Z85.4 Personal history of malignant neoplasm of genital organs
0.735 0.265 0.000
R63 Symptoms and signs concerning food and fluid intake
0.734 0.266 0.000
Z91.6 Personal history of other physical trauma
0.734 0.266 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.734 0.266 0.000
E00-E07 Disorders of thyroid gland
0.734 0.266 0.000
C77.1 Intrathoracic lymph nodes
0.734 0.266 0.000
H40.2 Primary angle-closure glaucoma
0.733 0.267 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.731 0.269 0.000
M47.8 Other spondylosis
0.730 0.270 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.729 0.270 0.000
I26 Pulmonary embolism
0.728 0.272 0.000
Z83.3 Family history of diabetes mellitus
0.727 0.273 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.726 0.274 0.000
Z96.0 Presence of urogenital implants
0.726 0.274 0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract
0.726 0.274 0.000
H33.0 Retinal detachment with retinal break
0.725 0.275 0.000
T51 Toxic effect of alcohol
0.724 0.276 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.724 0.276 0.000
Y52 Agents primarily affecting the cardiovascular system
0.724 0.276 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.723 0.277 0.000
Z93 Artificial opening status
0.722 0.278 0.000
M86-M90 Other osteopathies
0.721 0.279 0.000
T39.0 Salicylates
0.721 0.279 0.000
B65-B83 Helminthiases
0.720 0.280 0.000
Y84.0 Cardiac catheterisation
0.720 0.280 0.000
I33 Acute and subacute endocarditis
0.719 0.281 0.000
R02 Gangrene, not elsewhere classified
0.719 0.281 0.000
R05 Cough
0.718 0.282 0.000
H80-H83 Diseases of inner ear
0.718 0.282 0.000
B95-B98 Bacterial, viral and other infectious agents
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T79-T79 Certain early complications of trauma
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.717 0.283 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
J90 Pleural effusion, not elsewhere classified
0.717 0.283 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.716 0.284 0.000
Y84.8 Other medical procedures
0.716 0.284 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.284 0.000
I48 Atrial fibrillation and flutter
0.716 0.284 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.284 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.284 0.000
I40 Acute myocarditis
0.716 0.284 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.284 0.000
I37 Pulmonary valve disorders
0.716 0.284 0.000
I36 Nonrheumatic tricuspid valve disorders
0.716 0.284 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.284 0.000
M60-M63 Disorders of muscles
0.715 0.285 0.000
M00-M03 Infectious arthropathies
0.715 0.285 0.000
I42.9 Cardiomyopathy, unspecified
0.715 0.285 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.714 0.286 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.714 0.286 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.714 0.286 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.714 0.286 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.714 0.286 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.714 0.286 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.714 0.286 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.714 0.286 0.000
T36 Poisoning by systemic antibiotics
0.714 0.286 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.714 0.286 0.000
Y35-Y36 Legal intervention and operations of war
0.714 0.286 0.000
Y10-Y34 Event of undetermined intent
0.714 0.286 0.000
Y00-Y09 Assault
0.714 0.286 0.000
X85-X99 Assault
0.714 0.286 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.714 0.286 0.000
X50-X57 Overexertion, travel and privation
0.714 0.286 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.714 0.286 0.000
X30-X39 Exposure to forces of nature
0.714 0.286 0.000
X20-X29 Contact with venomous animals and plants
0.714 0.286 0.000
X10-X19 Contact with heat and hot substances
0.714 0.286 0.000
X00-X09 Exposure to smoke, fire and flames
0.714 0.286 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.714 0.286 0.000
W75-W84 Other accidental threats to breathing
0.714 0.286 0.000
W65-W74 Accidental drowning and submersion
0.714 0.286 0.000
W50-W64 Exposure to animate mechanical forces
0.714 0.286 0.000
V98-V99 Other and unspecified transport accidents
0.714 0.286 0.000
V95-V97 Air and space transport accidents
0.714 0.286 0.000
V90-V94 Water transport accidents
0.714 0.286 0.000
V80-V89 Other land transport accidents
0.714 0.286 0.000
V70-V79 Bus occupant injured in transport accident
0.714 0.286 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.714 0.286 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.714 0.286 0.000
V40-V49 Car occupant injured in transport accident
0.714 0.286 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.714 0.286 0.000
V20-V29 Motorcycle rider injured in transport accident
0.714 0.286 0.000
V01-V09 Pedestrian injured in transport accident
0.714 0.286 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.713 0.287 0.000
Z48.8 Other specified surgical follow-up care
0.713 0.287 0.000
H43-H45 Disorders of vitreous body and globe
0.712 0.288 0.000
R40 Somnolence, stupor and coma
0.711 0.288 0.000
R94 Abnormal results of function studies
0.710 0.290 0.000
C43 Malignant melanoma of skin
0.710 0.290 0.000
Z89 Acquired absence of limb
0.710 0.290 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.710 0.290 0.000
S90-S99 Injuries to the ankle and foot
0.710 0.290 0.000
I07 Rheumatic tricuspid valve diseases
0.710 0.290 0.000
M22.4 Chondromalacia patellae
0.709 0.291 0.000
I60-I69 Cerebrovascular diseases
0.709 0.291 0.000
C60-C63 Malignant neoplasms of male genital organs
0.708 0.292 0.000
M53 Other dorsopathies, not elsewhere classified
0.707 0.292 0.000
S60-S69 Injuries to the wrist and hand
0.708 0.292 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.707 0.293 0.000
D73 Diseases of spleen
0.707 0.293 0.000
S81 Open wound of lower leg
0.706 0.294 0.000
I44.2 Atrioventricular block, complete
0.706 0.294 0.000
I45 Other conduction disorders
0.706 0.294 0.000
M54.3 Sciatica
0.705 0.295 0.000
C77.4 Inguinal and lower limb lymph nodes
0.705 0.295 0.000
S29 Other and unspecified injuries of thorax
0.704 0.296 0.000
R56 Convulsions, not elsewhere classified
0.703 0.296 0.000
E03 Other hypothyroidism
0.703 0.297 0.000
I38 Endocarditis, valve unspecified
0.703 0.297 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.702 0.297 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.702 0.297 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.702 0.297 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.702 0.297 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.701 0.299 0.000
M23 Internal derangement of knee
0.700 0.300 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.700 0.300 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.699 0.300 0.000
M54.8 Other dorsalgia
0.699 0.301 0.000
M54.6 Pain in thoracic spine
0.699 0.301 0.000
M54.4 Lumbago with sciatica
0.699 0.301 0.000
M54.0 Panniculitis affecting regions of neck and back
0.699 0.301 0.000
Y43.3 Other antineoplastic drugs
0.698 0.302 0.000
I85.9 Oesophageal varices without bleeding
0.697 0.303 0.000
M93 Other osteochondropathies
0.697 0.303 0.000
H55-H59 Other disorders of eye and adnexa
0.697 0.303 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.695 0.305 0.000
S02 Fracture of skull and facial bones
0.695 0.305 0.000
R46 Symptoms and signs involving appearance and behaviour
0.694 0.306 0.000
R43 Disturbances of smell and taste
0.694 0.306 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.694 0.306 0.000
W19.4 Street and highway
0.693 0.307 0.000
H73 Other disorders of tympanic membrane
0.692 0.308 0.000
M54.55 Low back pain (Thoracolumbar region)
0.692 0.308 0.000
M54.54 Low back pain-Thoracic
0.692 0.308 0.000
M54.53 Low back pain-Cervicothoracic
0.692 0.308 0.000
M54.52 Low back pain-Cervical
0.692 0.308 0.000
M54.51 Low back pain-Occipit-atl-axl
0.692 0.308 0.000
M54.50 Low back pain (Multiple sites in spine)
0.692 0.308 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.692 0.308 0.000
C79.6 Secondary malignant neoplasm of ovary
0.691 0.308 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.691 0.308 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.691 0.308 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.691 0.308 0.000
S08 Traumatic amputation of part of head
0.691 0.309 0.000
S07 Crushing injury of head
0.691 0.309 0.000
S05 Injury of eye and orbit
0.691 0.309 0.000
S04 Injury of cranial nerves
0.691 0.309 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.691 0.309 0.000
Y57 Other and unspecified drugs and medicaments
0.690 0.310 0.000
C77.8 Lymph nodes of multiple regions
0.690 0.310 0.000
M21 Other acquired deformities of limbs
0.689 0.311 0.000
Z94.8 Other transplanted organ and tissue status
0.689 0.311 0.000
Z95.3 Presence of xenogenic heart valve
0.688 0.312 0.000
R21 Rash and other nonspecific skin eruption
0.687 0.313 0.000
R47-R49 Symptoms and signs involving speech and voice
0.687 0.313 0.000
M40-M43 Deforming dorsopathies
0.685 0.315 0.000
D37.6 Liver, gallbladder and bile ducts
0.685 0.315 0.000
H53.2 Diplopia
0.685 0.315 0.000
S01.0 Open wound of scalp
0.685 0.315 0.000
M05-M14 Inflammatory polyarthropathies
0.685 0.315 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.685 0.315 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.685 0.315 0.000
R62 Lack of expected normal physiological development
0.685 0.315 0.000
R64 Cachexia
0.685 0.315 0.000
R58 Haemorrhage, not elsewhere classified
0.685 0.315 0.000
W19.9 Unspecified place
0.685 0.315 0.000
J93 Pneumothorax
0.685 0.315 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.684 0.316 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.684 0.316 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.682 0.318 0.000
R73 Elevated blood glucose level
0.682 0.318 0.000
Z84 Family history of other conditions
0.682 0.318 0.000
Z81 Family history of mental and behavioural disorders
0.682 0.318 0.000
E03.9 Hypothyroidism, unspecified
0.681 0.319 0.000
Y84.6 Urinary catheterisation
0.681 0.319 0.000
I88 Nonspecific lymphadenitis
0.678 0.322 0.000
I82 Other venous embolism and thrombosis
0.678 0.322 0.000
I81 Portal vein thrombosis
0.678 0.322 0.000
M47.86 Other spondylosis (Lumbar region)
0.678 0.322 0.000
G40-G47 Episodic and paroxysmal disorders
0.678 0.322 0.000
T43.9 Psychotropic drug, unspecified
0.677 0.323 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.677 0.323 0.000
T43.6 Psychostimulants with abuse potential
0.677 0.323 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.677 0.323 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.677 0.323 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.677 0.323 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.677 0.323 0.000
A30-A49 Other bacterial diseases
0.677 0.323 0.000
R82 Other abnormal findings in urine
0.676 0.324 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.675 0.325 0.000
M34 Systemic sclerosis
0.675 0.325 0.000
M33 Dermatopolymyositis
0.675 0.325 0.000
M32 Systemic lupus erythematosus
0.675 0.325 0.000
M31 Other necrotising vasculopathies
0.675 0.325 0.000
M30 Polyarteritis nodosa and related conditions
0.675 0.325 0.000
R68 Other general symptoms and signs
0.675 0.325 0.000
Z95.2 Presence of prosthetic heart valve
0.674 0.326 0.000
I47.1 Supraventricular tachycardia
0.673 0.327 0.000
H33.5 Other retinal detachments
0.673 0.327 0.000
R52.1 Chronic intractable pain
0.673 0.327 0.000
D72 Other disorders of white blood cells
0.673 0.327 0.000
H11 Other disorders of conjunctiva
0.673 0.327 0.000
I09 Other rheumatic heart diseases
0.673 0.327 0.000
I06 Rheumatic aortic valve diseases
0.673 0.327 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.672 0.328 0.000
I73 Other peripheral vascular diseases
0.671 0.329 0.000
M54.22 Cervicalgia (Cervical region)
0.671 0.329 0.000
Z92.3 Personal history of irradiation
0.670 0.330 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.670 0.330 0.000
D80-D89 Certain disorders involving the immune mechanism
0.670 0.330 0.000
D55-D59 Haemolytic anaemias
0.670 0.330 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.670 0.330 0.000
R61 Hyperhidrosis
0.670 0.330 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.669 0.331 0.000
V10-V19 Pedal cyclist injured in transport accident
0.668 0.331 0.000
Y40 Systemic antibiotics
0.668 0.331 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.668 0.332 0.000
C71 Malignant neoplasm of brain
0.667 0.332 0.000
I46 Cardiac arrest
0.667 0.333 0.000
I27.0 Primary pulmonary hypertension
0.666 0.334 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.666 0.334 0.000
M54.9 Dorsalgia, unspecified
0.665 0.335 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.665 0.335 0.000
B34 Viral infection of unspecified site
0.665 0.335 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.664 0.336 0.000
M51.8 Other specified intervertebral disk disorders
0.664 0.336 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.664 0.336 0.000
M65-M68 Disorders of synovium and tendon
0.664 0.336 0.000
R41.3 Other amnesia
0.664 0.336 0.000
W22 Striking against or struck by other objects
0.663 0.337 0.000
T42.4 Benzodiazepines
0.661 0.339 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.661 0.339 0.000
D74 Methaemoglobinaemia
0.661 0.339 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.661 0.339 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.661 0.339 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.659 0.341 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.659 0.341 0.000
T39.4 Antirheumatics, not elsewhere classified
0.659 0.341 0.000
T39.2 Pyrazolone derivatives
0.659 0.341 0.000
Y44 Agents primarily affecting blood constituents
0.659 0.341 0.000
Z96.8 Presence of other specified functional implants
0.659 0.341 0.000
D45 Polycythaemia vera
0.658 0.342 0.000
Y59 Other and unspecified vaccines and biological substances
0.658 0.342 0.000
Y58 Bacterial vaccines
0.658 0.342 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.658 0.342 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.658 0.342 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.658 0.342 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.658 0.342 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.658 0.342 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.658 0.342 0.000
Y48 Anaesthetics and therapeutic gases
0.658 0.342 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.658 0.342 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.658 0.342 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.658 0.342 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.658 0.342 0.000
R60.0 Localised oedema
0.658 0.342 0.000
H60-H62 Diseases of external ear
0.657 0.342 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.656 0.344 0.000
Y95 Nosocomial condition
0.656 0.344 0.000
H35 Other retinal disorders
0.655 0.344 0.000
C51-C58 Malignant neoplasms of female genital organs
0.655 0.345 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.653 0.347 0.000
D46 Myelodysplastic syndromes
0.653 0.347 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.653 0.347 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.653 0.347 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.653 0.347 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.653 0.347 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.653 0.347 0.000
I51.8 Other ill-defined heart diseases
0.653 0.347 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.653 0.347 0.000
J60-J70 Lung diseases due to external agents
0.652 0.347 0.000
T66-T78 Other and unspecified effects of external causes
0.652 0.348 0.000
Z83.5 Family history of eye and ear disorders
0.652 0.348 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.651 0.349 0.000
M54.1 Radiculopathy
0.651 0.349 0.000
S89 Other and unspecified injuries of lower leg
0.651 0.349 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.651 0.349 0.000
D00-D09 In situ neoplasms
0.650 0.350 0.000
Z96.6 Presence of orthopaedic joint implants
0.650 0.350 0.000
M24 Other specific joint derangements
0.650 0.350 0.000
C77.9 Lymph node, unspecified
0.650 0.350 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.649 0.351 0.000
M25.46 Effusion of joint (Lower leg)
0.649 0.351 0.000
G90-G99 Other disorders of the nervous system
0.648 0.352 0.000
I42.8 Other cardiomyopathies
0.647 0.353 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.647 0.353 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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