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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs117956319
log Bayes Factor = 13.4307
Chromosome 8   position 32,191,896  (GRCh37) Explore rs117956319 on Ensembl!
Variant rs117956319 is part of Cluster X0222

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I30-I52 Other forms of heart disease
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
M70-M79 Other soft tissue disorders
0.999 0.001 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
I50 Heart failure
0.995 0.005 0.000
I34 Nonrheumatic mitral valve disorders
0.992 0.008 0.000
M75 Shoulder lesions
0.991 0.009 0.000
M20-M25 Other joint disorders
0.988 0.012 0.000
I44 Atrioventricular and left bundle-branch block
0.985 0.015 0.000
H30-H36 Disorders of choroid and retina
0.984 0.016 0.000
Chapter II Neoplasms
0.979 0.021 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.979 0.021 0.000
I34.0 Mitral (valve) insufficiency
0.978 0.022 0.000
I42 Cardiomyopathy
0.969 0.031 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.964 0.036 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.963 0.037 0.000
H35 Other retinal disorders
0.959 0.041 0.000
I50.1 Left ventricular failure
0.958 0.042 0.000
Chapter VIII Diseases of the ear and mastoid process
0.958 0.042 0.000
E10-E14 Diabetes mellitus
0.953 0.047 0.000
M80-M85 Disorders of bone density and structure
0.949 0.051 0.000
Chapter VI Diseases of the nervous system
0.949 0.051 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.946 0.054 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.944 0.056 0.000
H40-H42 Glaucoma
0.939 0.061 0.000
H35.3 Degeneration of macula and posterior pole
0.937 0.063 0.000
M75.0 Adhesive capsulitis of shoulder
0.934 0.066 0.000
E50-E64 Other nutritional deficiencies
0.933 0.067 0.000
M75.1 Rotator cuff syndrome
0.932 0.068 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.931 0.069 0.000
I42.0 Dilated cardiomyopathy
0.922 0.078 0.000
I50.0 Congestive heart failure
0.921 0.079 0.000
I51 Complications and ill-defined descriptions of heart disease
0.918 0.082 0.000
H90-H95 Other disorders of ear
0.915 0.085 0.000
I44.7 Left bundle-branch block, unspecified
0.915 0.085 0.000
M77 Other enthesopathies
0.912 0.088 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.904 0.096 0.000
H40 Glaucoma
0.896 0.104 0.000
E11 Non-insulin-dependent diabetes mellitus
0.893 0.107 0.000
I51.8 Other ill-defined heart diseases
0.891 0.109 0.000
I50.9 Heart failure, unspecified
0.889 0.111 0.000
M22 Disorders of patella
0.887 0.113 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.881 0.119 0.000
E10 Insulin-dependent diabetes mellitus
0.881 0.119 0.000
M79.0 Rheumatism, unspecified
0.879 0.121 0.000
M35 Other systemic involvement of connective tissue
0.878 0.122 0.000
I34.1 Mitral (valve) prolapse
0.878 0.122 0.000
I77 Other disorders of arteries and arterioles
0.876 0.124 0.000
Chapter XX External causes of morbidity and mortality
0.873 0.127 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.865 0.135 0.000
M20 Acquired deformities of fingers and toes
0.863 0.137 0.000
C15-C26 Malignant neoplasms of digestive organs
0.862 0.138 0.000
I05-I09 Chronic rheumatic heart diseases
0.860 0.140 0.000
H40.9 Glaucoma, unspecified
0.860 0.140 0.000
I45 Other conduction disorders
0.857 0.143 0.000
I44.0 Atrioventricular block, first degree
0.856 0.144 0.000
H53-H54 Visual disturbances and blindness
0.854 0.146 0.000
M85 Other disorders of bone density and structure
0.854 0.146 0.000
H36 Retinal disorders in diseases classified elsewhere
0.854 0.146 0.000
I49 Other cardiac arrhythmias
0.852 0.148 0.000
I71 Aortic aneurysm and dissection
0.848 0.152 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.845 0.155 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.842 0.158 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.838 0.161 0.000
E11.4 With neurological complications
0.837 0.163 0.000
M50-M54 Other dorsopathies
0.831 0.169 0.000
M05-M14 Inflammatory polyarthropathies
0.831 0.169 0.000
M79.09 Rheumatism, unspecified (Site unspecified)
0.830 0.170 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.830 0.170 0.000
H90 Conductive and sensorineural hearing loss
0.829 0.171 0.000
C78.7 Secondary malignant neoplasm of liver
0.822 0.178 0.000
I77.1 Stricture of artery
0.822 0.178 0.000
H91 Other hearing loss
0.822 0.178 0.000
M77.1 Lateral epicondylitis
0.822 0.178 0.000
E20-E35 Disorders of other endocrine glands
0.822 0.178 0.000
C78.0 Secondary malignant neoplasm of lung
0.821 0.179 0.000
H65-H75 Diseases of middle ear and mastoid
0.819 0.181 0.000
I44.6 Other and unspecified fascicular block
0.819 0.181 0.000
I35 Nonrheumatic aortic valve disorders
0.819 0.181 0.000
I44.1 Atrioventricular block, second degree
0.818 0.182 0.000
E53 Deficiency of other B group vitamins
0.814 0.186 0.000
Chapter X Diseases of the respiratory system
0.814 0.186 0.000
S70-S79 Injuries to the hip and thigh
0.813 0.187 0.000
E55 Vitamin D deficiency
0.806 0.194 0.000
S80-S89 Injuries to the knee and lower leg
0.805 0.195 0.000
H33 Retinal detachments and breaks
0.803 0.197 0.000
C18 Malignant neoplasm of colon
0.802 0.198 0.000
C78.2 Secondary malignant neoplasm of pleura
0.802 0.198 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.801 0.199 0.000
I46 Cardiac arrest
0.801 0.199 0.000
G30-G32 Other degenerative diseases of the nervous system
0.801 0.199 0.000
I42.9 Cardiomyopathy, unspecified
0.801 0.199 0.000
M22.4 Chondromalacia patellae
0.799 0.201 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.798 0.202 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.796 0.204 0.000
E10.9 Without complications
0.796 0.204 0.000
J09-J18 Influenza and pneumonia
0.792 0.208 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.792 0.208 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.790 0.209 0.000
M75.3 Calcific tendinitis of shoulder
0.790 0.210 0.000
M21 Other acquired deformities of limbs
0.789 0.211 0.000
M23 Internal derangement of knee
0.788 0.211 0.000
M35.0 Sicca syndrome [Sjogren]
0.787 0.213 0.000
M85.8 Other specified disorders of bone density and structure
0.786 0.214 0.000
I26 Pulmonary embolism
0.785 0.215 0.000
E61 Deficiency of other nutrient elements
0.784 0.216 0.000
M80 Osteoporosis with pathological fracture
0.784 0.216 0.000
C51-C58 Malignant neoplasms of female genital organs
0.782 0.218 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.781 0.219 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.780 0.220 0.000
D50-D53 Nutritional anaemias
0.778 0.222 0.000
I37 Pulmonary valve disorders
0.778 0.222 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.777 0.223 0.000
J18 Pneumonia, organism unspecified
0.777 0.223 0.000
M81 Osteoporosis without pathological fracture
0.777 0.223 0.000
H52 Disorders of refraction and accommodation
0.776 0.224 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.775 0.225 0.000
H40.1 Primary open-angle glaucoma
0.774 0.226 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.772 0.228 0.000
M20.4 Other hammer toe(s) (acquired)
0.770 0.230 0.000
S00-S09 Injuries to the head
0.770 0.230 0.000
S10-S19 Injuries to the neck
0.768 0.232 0.000
M31 Other necrotising vasculopathies
0.768 0.232 0.000
M86-M90 Other osteopathies
0.767 0.233 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.764 0.236 0.000
M75.4 Impingement syndrome of shoulder
0.764 0.236 0.000
I30 Acute pericarditis
0.760 0.239 0.000
H36.0 Diabetic retinopathy
0.760 0.240 0.000
M45-M49 Spondylopathies
0.759 0.241 0.000
C77.2 Intra-abdominal lymph nodes
0.758 0.242 0.000
M77.12 Lateral epicondylitis (Upper arm)
0.757 0.243 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.755 0.244 0.000
H91.9 Hearing loss, unspecified
0.755 0.245 0.000
I49.3 Ventricular premature depolarisation
0.755 0.245 0.000
M50 Cervical disk disorders
0.754 0.246 0.000
H33.0 Retinal detachment with retinal break
0.754 0.246 0.000
J18.9 Pneumonia, unspecified
0.754 0.246 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.753 0.247 0.000
I08 Multiple valve diseases
0.753 0.247 0.000
C77.5 Intrapelvic lymph nodes
0.753 0.247 0.000
M75.2 Bicipital tendinitis
0.751 0.249 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.750 0.250 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.750 0.250 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.748 0.252 0.000
I44.3 Other and unspecified atrioventricular block
0.748 0.252 0.000
H43-H45 Disorders of vitreous body and globe
0.748 0.252 0.000
M65-M68 Disorders of synovium and tendon
0.748 0.252 0.000
H35.9 Retinal disorder, unspecified
0.747 0.253 0.000
E11.5 With peripheral circulatory complications
0.745 0.255 0.000
M75.5 Bursitis of shoulder
0.742 0.258 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.742 0.258 0.000
I42.2 Other hypertrophic cardiomyopathy
0.741 0.259 0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)
0.737 0.263 0.000
D80-D89 Certain disorders involving the immune mechanism
0.735 0.265 0.000
S20-S29 Injuries to the thorax
0.734 0.266 0.000
M77.0 Medial epicondylitis
0.733 0.267 0.000
T79-T79 Certain early complications of trauma
0.732 0.268 0.000
G57 Mononeuropathies of lower limb
0.732 0.268 0.000
H10-H13 Disorders of conjunctiva
0.731 0.269 0.000
S50-S59 Injuries to the elbow and forearm
0.731 0.269 0.000
M35.7 Hypermobility syndrome
0.730 0.270 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.730 0.270 0.000
E53.8 Deficiency of other specified B group vitamins
0.729 0.271 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.728 0.272 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.728 0.272 0.000
H55-H59 Other disorders of eye and adnexa
0.725 0.275 0.000
E11.6 With other specified complications
0.724 0.276 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.724 0.276 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.723 0.277 0.000
H35.8 Other specified retinal disorders
0.723 0.277 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.722 0.278 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.720 0.280 0.000
M91-M94 Chondropathies
0.719 0.281 0.000
M79.1 Myalgia
0.719 0.281 0.000
I45.1 Other and unspecified right bundle-branch block
0.719 0.281 0.000
H54 Blindness and low vision
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.717 0.283 0.000
M76 Enthesopathies of lower limb, excluding foot
0.716 0.284 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.716 0.284 0.000
M71 Other bursopathies
0.716 0.284 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.716 0.284 0.000
E11.3 With ophthalmic complications
0.716 0.284 0.000
H93 Other disorders of ear, not elsewhere classified
0.715 0.285 0.000
E55.9 Vitamin D deficiency, unspecified
0.714 0.286 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.712 0.288 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.711 0.289 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.711 0.289 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.711 0.289 0.000
M75.8 Other shoulder lesions
0.711 0.289 0.000
M75.9 Shoulder lesion, unspecified
0.711 0.289 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.711 0.289 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.710 0.290 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.710 0.290 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.708 0.291 0.000
M34 Systemic sclerosis
0.708 0.291 0.000
M33 Dermatopolymyositis
0.708 0.291 0.000
M32 Systemic lupus erythematosus
0.708 0.291 0.000
M30 Polyarteritis nodosa and related conditions
0.708 0.291 0.000
C80 Malignant neoplasm without specification of site
0.707 0.293 0.000
M50.3 Other cervical disk degeneration
0.707 0.293 0.000
E13 Other specified diabetes mellitus
0.706 0.294 0.000
I44.5 Left posterior fascicular block
0.706 0.294 0.000
I44.4 Left anterior fascicular block
0.706 0.294 0.000
E40-E46 Malnutrition
0.706 0.294 0.000
M25 Other joint disorders, not elsewhere classified
0.705 0.295 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.705 0.295 0.000
H31 Other disorders of choroid
0.705 0.295 0.000
H30 Chorioretinal inflammation
0.705 0.295 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.705 0.295 0.000
D00-D09 In situ neoplasms
0.702 0.297 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.702 0.298 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.702 0.298 0.000
M07 Psoriatic and enteropathic arthropathies
0.701 0.299 0.000
M22.8 Other disorders of patella
0.701 0.299 0.000
M20.1 Hallux valgus (acquired)
0.701 0.299 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.700 0.300 0.000
H52.1 Myopia
0.700 0.300 0.000
W20-W49 Exposure to inanimate mechanical forces
0.699 0.301 0.000
J60-J70 Lung diseases due to external agents
0.698 0.302 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.698 0.302 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.696 0.304 0.000
I33 Acute and subacute endocarditis
0.695 0.305 0.000
I46.0 Cardiac arrest with successful resuscitation
0.695 0.305 0.000
I42.8 Other cardiomyopathies
0.695 0.305 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.695 0.305 0.000
I42.6 Alcoholic cardiomyopathy
0.695 0.305 0.000
I42.5 Other restrictive cardiomyopathy
0.695 0.305 0.000
I42.4 Endocardial fibroelastosis
0.695 0.305 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.695 0.305 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.693 0.307 0.000
G90-G99 Other disorders of the nervous system
0.693 0.307 0.000
Chapter XXII Codes for special purposes
0.692 0.307 0.000
G54 Nerve root and plexus disorders
0.692 0.308 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.691 0.309 0.000
T33-T35 Frostbite
0.690 0.309 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.690 0.309 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.690 0.309 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.690 0.309 0.000
T00-T07 Injuries involving multiple body regions
0.690 0.309 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.690 0.309 0.000
M79.8 Other specified soft tissue disorders
0.690 0.310 0.000
I05 Rheumatic mitral valve diseases
0.690 0.310 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.690 0.310 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.689 0.311 0.000
M84 Disorders of continuity of bone
0.689 0.311 0.000
G70-G73 Diseases of myoneural junction and muscle
0.688 0.311 0.000
E10.3 With ophthalmic complications
0.688 0.312 0.000
M40-M43 Deforming dorsopathies
0.688 0.312 0.000
H35.7 Separation of retinal layers
0.688 0.312 0.000
H35.6 Retinal haemorrhage
0.688 0.312 0.000
H35.5 Hereditary retinal dystrophy
0.688 0.312 0.000
H35.2 Other proliferative retinopathy
0.688 0.312 0.000
H35.1 Retinopathy of prematurity
0.688 0.312 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.687 0.313 0.000
C18.9 Colon, unspecified
0.687 0.313 0.000
J18.1 Lobar pneumonia, unspecified
0.687 0.313 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.686 0.314 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.686 0.314 0.000
C91 Lymphoid leukaemia
0.685 0.315 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.685 0.315 0.000
E12 Malnutrition-related diabetes mellitus
0.684 0.316 0.000
E10.5 With peripheral circulatory complications
0.683 0.316 0.000
I44.2 Atrioventricular block, complete
0.683 0.317 0.000
H35.0 Background retinopathy and retinal vascular changes
0.681 0.319 0.000
D55-D59 Haemolytic anaemias
0.681 0.319 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.681 0.319 0.000
M53 Other dorsopathies, not elsewhere classified
0.681 0.319 0.000
M83 Adult osteomalacia
0.680 0.319 0.000
M82 Osteoporosis in diseases classified elsewhere
0.680 0.319 0.000
H50 Other strabismus
0.680 0.320 0.000
H90.2 Conductive hearing loss, unspecified
0.679 0.321 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.678 0.322 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.678 0.322 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.678 0.322 0.000
I45.9 Conduction disorder, unspecified
0.678 0.322 0.000
E61.1 Iron deficiency
0.677 0.323 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.677 0.323 0.000
C18.0 Caecum
0.677 0.323 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.677 0.323 0.000
I72 Other aneurysm
0.677 0.323 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.675 0.325 0.000
D50 Iron deficiency anaemia
0.675 0.325 0.000
E11.2 With renal complications
0.673 0.327 0.000
H42 Glaucoma in diseases classified elsewhere
0.673 0.327 0.000
I38 Endocarditis, valve unspecified
0.671 0.329 0.000
C56 Malignant neoplasm of ovary
0.671 0.329 0.000
H53 Visual disturbances
0.671 0.329 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.669 0.331 0.000
E63 Other nutritional deficiencies
0.669 0.331 0.000
E56 Other vitamin deficiencies
0.669 0.331 0.000
E51 Thiamine deficiency
0.669 0.331 0.000
E50 Vitamin A deficiency
0.669 0.331 0.000
E60 Dietary zinc deficiency
0.669 0.331 0.000
E59 Dietary selenium deficiency
0.669 0.331 0.000
E58 Dietary calcium deficiency
0.669 0.331 0.000
E54 Ascorbic acid deficiency
0.669 0.331 0.000
E52 Niacin deficiency [pellagra]
0.669 0.331 0.000
H60-H62 Diseases of external ear
0.668 0.331 0.000
I31 Other diseases of pericardium
0.668 0.332 0.000
I49.4 Other and unspecified premature depolarisation
0.668 0.332 0.000
S72 Fracture of femur
0.668 0.332 0.000
M79.9 Soft tissue disorder, unspecified
0.667 0.333 0.000
M79.5 Residual foreign body in soft tissue
0.667 0.333 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.667 0.333 0.000
M79.3 Panniculitis, unspecified
0.667 0.333 0.000
M79.2 Neuralgia and neuritis, unspecified
0.667 0.333 0.000
I74 Arterial embolism and thrombosis
0.667 0.333 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.666 0.334 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.666 0.334 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.665 0.335 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.664 0.336 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.662 0.337 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.662 0.337 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.662 0.338 0.000
S80 Superficial injury of lower leg
0.662 0.338 0.000
I70 Atherosclerosis
0.661 0.339 0.000
M24 Other specific joint derangements
0.659 0.341 0.000
C18.1 Appendix
0.658 0.342 0.000
M20.5 Other deformities of toe(s) (acquired)
0.658 0.342 0.000
I51.6 Cardiovascular disease, unspecified
0.658 0.342 0.000
I51.5 Myocardial degeneration
0.658 0.342 0.000
I51.4 Myocarditis, unspecified
0.658 0.342 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.658 0.342 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.658 0.342 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.658 0.342 0.000
I51.0 Cardiac septal defect, acquired
0.658 0.342 0.000
H35.4 Peripheral retinal degeneration
0.657 0.343 0.000
G61 Inflammatory polyneuropathy
0.656 0.344 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.656 0.344 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.656 0.344 0.000
V80-V89 Other land transport accidents
0.656 0.344 0.000
M77.9 Enthesopathy, unspecified
0.654 0.346 0.000
M77.8 Other enthesopathies, not elsewhere classified
0.654 0.346 0.000
M77.5 Other enthesopathy of foot
0.654 0.346 0.000
M77.4 Metatarsalgia
0.654 0.346 0.000
M77.3 Calcaneal spur
0.654 0.346 0.000
M77.2 Periarthritis of wrist
0.654 0.346 0.000
G82 Paraplegia and tetraplegia
0.653 0.347 0.000
G57.6 Lesion of plantar nerve
0.653 0.347 0.000
M81.9 Osteoporosis, unspecified
0.653 0.347 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.652 0.348 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.651 0.349 0.000
I78 Diseases of capillaries
0.651 0.349 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.651 0.349 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.650 0.350 0.000
S82 Fracture of lower leg, including ankle
0.649 0.351 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.647 0.353 0.000
S01 Open wound of head
0.647 0.353 0.000
S02 Fracture of skull and facial bones
0.645 0.355 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.645 0.355 0.000
H74 Other disorders of middle ear and mastoid
0.645 0.355 0.000
I49.1 Atrial premature depolarisation
0.645 0.355 0.000
S70 Superficial injury of hip and thigh
0.644 0.356 0.000
H40.8 Other glaucoma
0.642 0.358 0.000
H40.6 Glaucoma secondary to drugs
0.642 0.358 0.000
H40.5 Glaucoma secondary to other eye disorders
0.642 0.358 0.000
H40.4 Glaucoma secondary to eye inflammation
0.642 0.358 0.000
H40.3 Glaucoma secondary to eye trauma
0.642 0.358 0.000
E11.8 With unspecified complications
0.640 0.359 0.000
E11.7 With multiple complications
0.640 0.359 0.000
E11.1 With ketoacidosis
0.640 0.359 0.000
E11.0 With coma
0.640 0.359 0.000
M79.6 Pain in limb
0.640 0.360 0.000
H65 Nonsuppurative otitis media
0.639 0.361 0.000
I49.0 Ventricular fibrillation and flutter
0.638 0.362 0.000
M22.1 Recurrent subluxation of patella
0.636 0.364 0.000
M22.9 Disorder of patella, unspecified
0.636 0.364 0.000
M22.3 Other derangements of patella
0.636 0.364 0.000
M22.0 Recurrent dislocation of patella
0.636 0.364 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.636 0.364 0.000
Q00-Q07 Congenital malformations of the nervous system
0.636 0.364 0.000
I71.0 Dissection of aorta [any part]
0.635 0.364 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.635 0.365 0.000
S90-S99 Injuries to the ankle and foot
0.635 0.365 0.000
I35.8 Other aortic valve disorders
0.635 0.365 0.000
C77.0 Lymph nodes of head, face and neck
0.635 0.365 0.000
H90.3 Sensorineural hearing loss, bilateral
0.634 0.366 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.633 0.367 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.632 0.368 0.000
H51 Other disorders of binocular movement
0.631 0.368 0.000
H49 Paralytic strabismus
0.631 0.368 0.000
E10.8 With unspecified complications
0.631 0.368 0.000
E10.7 With multiple complications
0.631 0.368 0.000
E10.6 With other specified complications
0.631 0.368 0.000
E10.4 With neurological complications
0.631 0.368 0.000
E10.2 With renal complications
0.631 0.368 0.000
E10.1 With ketoacidosis
0.631 0.368 0.000
E10.0 With coma
0.631 0.368 0.000
H66 Suppurative and unspecified otitis media
0.631 0.369 0.000
M79.08 Rheumatism, unspecified (Other)
0.630 0.370 0.000
M79.07 Rheumatism, unspecified (Ankle and foot)
0.630 0.370 0.000
M79.06 Rheumatism, unspecified (Lower leg)
0.630 0.370 0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)
0.630 0.370 0.000
M79.04 Rheumatism, unspecified (Hand)
0.630 0.370 0.000
M79.03 Rheumatism, unspecified (Forearm)
0.630 0.370 0.000
M79.02 Rheumatism, unspecified (Upper arm)
0.630 0.370 0.000
M79.01 Rheumatism, unspecified (Shoulder region)
0.630 0.370 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.630 0.370 0.000
M35.8 Other specified systemic involvement of connective tissue
0.630 0.370 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.630 0.370 0.000
M35.5 Multifocal fibrosclerosis
0.630 0.370 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.630 0.370 0.000
M35.2 Behcet's disease
0.630 0.370 0.000
M35.1 Other overlap syndromes
0.630 0.370 0.000
E22 Hyperfunction of pituitary gland
0.629 0.371 0.000
I77.6 Arteritis, unspecified
0.628 0.372 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.628 0.372 0.000
I77.8 Other specified disorders of arteries and arterioles
0.628 0.372 0.000
I77.5 Necrosis of artery
0.628 0.372 0.000
I77.4 Coeliac artery compression syndrome
0.628 0.372 0.000
I77.3 Arterial fibromuscular dysplasia
0.628 0.372 0.000
I77.2 Rupture of artery
0.628 0.372 0.000
I77.0 Arteriovenous fistula, acquired
0.628 0.372 0.000
S12 Fracture of neck
0.628 0.372 0.000
M79.7 Fibromyalgia
0.626 0.374 0.000
Y35-Y36 Legal intervention and operations of war
0.626 0.374 0.000
Y10-Y34 Event of undetermined intent
0.626 0.374 0.000
Y00-Y09 Assault
0.626 0.374 0.000
X85-X99 Assault
0.626 0.374 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.626 0.374 0.000
X50-X57 Overexertion, travel and privation
0.626 0.374 0.000
X30-X39 Exposure to forces of nature
0.626 0.374 0.000
X20-X29 Contact with venomous animals and plants
0.626 0.374 0.000
X10-X19 Contact with heat and hot substances
0.626 0.374 0.000
X00-X09 Exposure to smoke, fire and flames
0.626 0.374 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.626 0.374 0.000
W75-W84 Other accidental threats to breathing
0.626 0.374 0.000
W65-W74 Accidental drowning and submersion
0.626 0.374 0.000
W50-W64 Exposure to animate mechanical forces
0.626 0.374 0.000
V98-V99 Other and unspecified transport accidents
0.626 0.374 0.000
V95-V97 Air and space transport accidents
0.626 0.374 0.000
V90-V94 Water transport accidents
0.626 0.374 0.000
V70-V79 Bus occupant injured in transport accident
0.626 0.374 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.626 0.374 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.626 0.374 0.000
V40-V49 Car occupant injured in transport accident
0.626 0.374 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.626 0.374 0.000
V01-V09 Pedestrian injured in transport accident
0.626 0.374 0.000
E29 Testicular dysfunction
0.625 0.375 0.000
C69 Malignant neoplasm of eye and adnexa
0.625 0.375 0.000
X60-X84 Intentional self-harm
0.625 0.375 0.000
C09 Malignant neoplasm of tonsil
0.624 0.376 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.624 0.376 0.000
C73 Malignant neoplasm of thyroid gland
0.623 0.377 0.000
E14 Unspecified diabetes mellitus
0.623 0.377 0.000
G30 Alzheimer's disease
0.622 0.377 0.000
I35.0 Aortic (valve) stenosis
0.622 0.377 0.000
M05 Seropositive rheumatoid arthritis
0.622 0.377 0.000
I51.9 Heart disease, unspecified
0.622 0.378 0.000
T92 Sequelae of injuries of upper limb
0.622 0.378 0.000
I28 Other diseases of pulmonary vessels
0.620 0.379 0.000
M20.0 Deformity of finger(s)
0.619 0.381 0.000
I37.1 Pulmonary valve insufficiency
0.619 0.381 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.618 0.382 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.618 0.382 0.000
C21 Malignant neoplasm of anus and anal canal
0.618 0.382 0.000
C17 Malignant neoplasm of small intestine
0.618 0.382 0.000
C23 Malignant neoplasm of gallbladder
0.618 0.382 0.000
I35.1 Aortic (valve) insufficiency
0.618 0.382 0.000
H90.5 Sensorineural hearing loss, unspecified
0.617 0.382 0.000
I09 Other rheumatic heart diseases
0.617 0.383 0.000
I06 Rheumatic aortic valve diseases
0.617 0.383 0.000
C77.8 Lymph nodes of multiple regions
0.617 0.383 0.000
T93 Sequelae of injuries of lower limb
0.616 0.384 0.000
J69 Pneumonitis due to solids and liquids
0.616 0.384 0.000
G59.0 Diabetic mononeuropathy
0.616 0.384 0.000
H54.9 Unspecified visual impairment (binocular)
0.615 0.385 0.000
I45.8 Other specified conduction disorders
0.615 0.385 0.000
I45.6 Preexcitation syndrome
0.615 0.385 0.000
I45.5 Other specified heart block
0.615 0.385 0.000
I45.4 Nonspecific intraventricular block
0.615 0.385 0.000
I45.3 Trifascicular block
0.615 0.385 0.000
I45.2 Bifascicular block
0.615 0.385 0.000
I45.0 Right fascicular block
0.615 0.385 0.000
C81 Hodgkin's disease
0.614 0.386 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.614 0.386 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.614 0.386 0.000
M72 Fibroblastic disorders
0.614 0.386 0.000
M21.0 Valgus deformity, not elsewhere classified
0.614 0.386 0.000
I08.8 Other multiple valve diseases
0.613 0.386 0.000
C01 Malignant neoplasm of base of tongue
0.612 0.387 0.000
M85.9 Disorder of bone density and structure, unspecified
0.612 0.388 0.000
M85.6 Other cyst of bone
0.612 0.388 0.000
M85.5 Aneurysmal bone cyst
0.612 0.388 0.000
M85.4 Solitary bone cyst
0.612 0.388 0.000
M85.3 Osteitis condensans
0.612 0.388 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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