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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs16845887
log Bayes Factor = 12.9189
Chromosome 4   position 72,005,823  (GRCh37) Explore rs16845887 on Ensembl!
Variant rs16845887 is part of Cluster X0224

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
0.998 0.002 0.000
Chapter XIV Diseases of the genitourinary system
0.998 0.002 0.000
J44 Other chronic obstructive pulmonary disease
0.997 0.003 0.000
J40-J47 Chronic lower respiratory diseases
0.997 0.003 0.000
Chapter VI Diseases of the nervous system
0.995 0.005 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.991 0.009 0.000
N17-N19 Renal failure
0.990 0.010 0.000
Chapter VII Diseases of the eye and adnexa
0.989 0.011 0.000
E10-E14 Diabetes mellitus
0.982 0.018 0.000
H30-H36 Disorders of choroid and retina
0.982 0.018 0.000
Chapter II Neoplasms
0.977 0.023 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.975 0.025 0.000
S00-S09 Injuries to the head
0.971 0.029 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.970 0.030 0.000
E10 Insulin-dependent diabetes mellitus
0.968 0.032 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.965 0.035 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.964 0.036 0.000
N18 Chronic renal failure
0.962 0.038 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.961 0.039 0.000
H33 Retinal detachments and breaks
0.961 0.039 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.951 0.049 0.000
C78.7 Secondary malignant neoplasm of liver
0.948 0.052 0.000
S01 Open wound of head
0.938 0.062 0.000
H33.0 Retinal detachment with retinal break
0.936 0.064 0.000
Chapter V Mental and behavioural disorders
0.936 0.064 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.923 0.077 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.922 0.078 0.000
Chapter VIII Diseases of the ear and mastoid process
0.920 0.080 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.916 0.084 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.912 0.088 0.000
N17 Acute renal failure
0.912 0.088 0.000
N00-N08 Glomerular diseases
0.908 0.092 0.000
J09-J18 Influenza and pneumonia
0.904 0.096 0.000
T91 Sequelae of injuries of neck and trunk
0.903 0.097 0.000
C78.2 Secondary malignant neoplasm of pleura
0.902 0.098 0.000
Chapter XI Diseases of the digestive system
0.898 0.102 0.000
G90-G99 Other disorders of the nervous system
0.898 0.102 0.000
N60-N64 Disorders of breast
0.898 0.102 0.000
K70-K77 Diseases of liver
0.890 0.110 0.000
E10.1 With ketoacidosis
0.885 0.115 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.884 0.116 0.000
G40-G47 Episodic and paroxysmal disorders
0.884 0.116 0.000
N40-N51 Diseases of male genital organs
0.881 0.119 0.000
S01.8 Open wound of other parts of head
0.879 0.121 0.000
K76 Other diseases of liver
0.874 0.126 0.000
N30-N39 Other diseases of urinary system
0.874 0.126 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.873 0.127 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.873 0.127 0.000
S50-S59 Injuries to the elbow and forearm
0.871 0.128 0.000
H02 Other disorders of eyelid
0.870 0.130 0.000
J90-J94 Other diseases of pleura
0.869 0.131 0.000
S20-S29 Injuries to the thorax
0.868 0.131 0.000
N32 Other disorders of bladder
0.866 0.134 0.000
N32.8 Other specified disorders of bladder
0.863 0.137 0.000
E65-E68 Obesity and other hyperalimentation
0.862 0.138 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.861 0.139 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.859 0.141 0.000
K56.6 Other and unspecified intestinal obstruction
0.858 0.142 0.000
H35 Other retinal disorders
0.856 0.144 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.855 0.145 0.000
S70-S79 Injuries to the hip and thigh
0.855 0.145 0.000
K55-K64 Other diseases of intestines
0.851 0.149 0.000
H65-H75 Diseases of middle ear and mastoid
0.851 0.149 0.000
C15-C26 Malignant neoplasms of digestive organs
0.851 0.149 0.000
G43 Migraine
0.850 0.150 0.000
S01.3 Open wound of ear
0.845 0.155 0.000
N17.9 Acute renal failure, unspecified
0.839 0.161 0.000
S90-S99 Injuries to the ankle and foot
0.837 0.163 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.837 0.163 0.000
H33.3 Retinal breaks without detachment
0.833 0.167 0.000
N18.5 Chronic kidney disease, stage 5
0.832 0.168 0.000
N48 Other disorders of penis
0.832 0.168 0.000
J18 Pneumonia, organism unspecified
0.831 0.169 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.829 0.171 0.000
N62 Hypertrophy of breast
0.828 0.172 0.000
G95 Other diseases of spinal cord
0.827 0.173 0.000
T92 Sequelae of injuries of upper limb
0.826 0.174 0.000
G57 Mononeuropathies of lower limb
0.824 0.176 0.000
S06 Intracranial injury
0.823 0.177 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.821 0.179 0.000
G43.9 Migraine, unspecified
0.817 0.183 0.000
E10.9 Without complications
0.816 0.184 0.000
E10.4 With neurological complications
0.816 0.184 0.000
T91.8 Sequelae of other specified injuries of neck and trunk
0.814 0.186 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.813 0.187 0.000
E11 Non-insulin-dependent diabetes mellitus
0.812 0.188 0.000
S10-S19 Injuries to the neck
0.811 0.189 0.000
S80-S89 Injuries to the knee and lower leg
0.810 0.190 0.000
E20-E35 Disorders of other endocrine glands
0.810 0.190 0.000
N10-N16 Renal tubulo-interstitial diseases
0.809 0.191 0.000
N18.4 Chronic kidney disease, stage 4
0.807 0.193 0.000
J43 Emphysema
0.804 0.196 0.000
J90 Pleural effusion, not elsewhere classified
0.804 0.196 0.000
O16 Unspecified maternal hypertension
0.803 0.197 0.000
S40-S49 Injuries to the shoulder and upper arm
0.802 0.198 0.000
E10.2 With renal complications
0.800 0.200 0.000
N19 Unspecified renal failure
0.800 0.200 0.000
K76.9 Liver disease, unspecified
0.799 0.201 0.000
H02.3 Blepharochalasis
0.796 0.204 0.000
N18.9 Chronic renal failure, unspecified
0.792 0.208 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.791 0.209 0.000
K70 Alcoholic liver disease
0.790 0.210 0.000
K76.6 Portal hypertension
0.789 0.211 0.000
N03 Chronic nephritic syndrome
0.788 0.212 0.000
G20-G26 Extrapyramidal and movement disorders
0.787 0.213 0.000
S52 Fracture of forearm
0.786 0.214 0.000
N18.0 End-stage renal disease
0.784 0.216 0.000
C50-C50 Malignant neoplasm of breast
0.783 0.217 0.000
F30-F39 Mood [affective] disorders
0.782 0.218 0.000
N18.3 Chronic kidney disease, stage 3
0.782 0.218 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.782 0.218 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.781 0.219 0.000
Chapter XXII Codes for special purposes
0.780 0.219 0.000
S05 Injury of eye and orbit
0.780 0.219 0.000
T86 Failure and rejection of transplanted organs and tissues
0.780 0.220 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.773 0.227 0.000
E10.5 With peripheral circulatory complications
0.773 0.227 0.000
H36 Retinal disorders in diseases classified elsewhere
0.771 0.229 0.000
Q50-Q56 Congenital malformations of genital organs
0.771 0.229 0.000
H35.4 Peripheral retinal degeneration
0.771 0.229 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.770 0.230 0.000
N99-N99 Other disorders of the genitourinary system
0.770 0.230 0.000
H04 Disorders of lachrymal system
0.769 0.231 0.000
G70-G73 Diseases of myoneural junction and muscle
0.769 0.231 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.768 0.232 0.000
G56 Mononeuropathies of upper limb
0.768 0.232 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.765 0.235 0.000
H02.4 Ptosis of eyelid
0.765 0.235 0.000
J47 Bronchiectasis
0.762 0.238 0.000
H34 Retinal vascular occlusions
0.761 0.239 0.000
H55-H59 Other disorders of eye and adnexa
0.761 0.239 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.759 0.240 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.759 0.241 0.000
O00-O08 Pregnancy with abortive outcome
0.755 0.245 0.000
H02.8 Other specified disorders of eyelid
0.755 0.245 0.000
G57.6 Lesion of plantar nerve
0.753 0.247 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.753 0.247 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.752 0.247 0.000
T66-T78 Other and unspecified effects of external causes
0.752 0.248 0.000
C16 Malignant neoplasm of stomach
0.752 0.248 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.751 0.249 0.000
F80-F89 Disorders of psychological development
0.749 0.251 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.748 0.252 0.000
C64-C68 Malignant neoplasms of urinary tract
0.748 0.252 0.000
E66 Obesity
0.747 0.253 0.000
N40 Hyperplasia of prostate
0.746 0.254 0.000
H60-H62 Diseases of external ear
0.745 0.255 0.000
Chapter I Certain infectious and parasitic diseases
0.744 0.256 0.000
C78.0 Secondary malignant neoplasm of lung
0.743 0.257 0.000
T90 Sequelae of injuries of head
0.742 0.258 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.742 0.258 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.741 0.259 0.000
S00 Superficial injury of head
0.741 0.259 0.000
H71 Cholesteatoma of middle ear
0.740 0.260 0.000
H02.1 Ectropion of eyelid
0.740 0.260 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.739 0.260 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.739 0.261 0.000
T91.9 Sequelae of unspecified injury of neck and trunk
0.738 0.262 0.000
E14 Unspecified diabetes mellitus
0.737 0.263 0.000
J18.1 Lobar pneumonia, unspecified
0.736 0.264 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.736 0.264 0.000
N48.8 Other specified disorders of penis
0.736 0.264 0.000
N61 Inflammatory disorders of breast
0.735 0.265 0.000
G30-G32 Other degenerative diseases of the nervous system
0.735 0.265 0.000
H10-H13 Disorders of conjunctiva
0.735 0.265 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.733 0.266 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.733 0.267 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.732 0.268 0.000
T98 Sequelae of other and unspecified effects of external causes
0.731 0.269 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.730 0.270 0.000
D00-D09 In situ neoplasms
0.730 0.270 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.730 0.270 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.729 0.271 0.000
E10.3 With ophthalmic complications
0.728 0.272 0.000
J30-J39 Other diseases of upper respiratory tract
0.728 0.272 0.000
N05 Unspecified nephritic syndrome
0.726 0.274 0.000
K56.2 Volvulus
0.725 0.275 0.000
S82 Fracture of lower leg, including ankle
0.724 0.276 0.000
S72 Fracture of femur
0.724 0.276 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.722 0.278 0.000
K56.4 Other impaction of intestine
0.722 0.278 0.000
H20 Iridocyclitis
0.721 0.279 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.721 0.279 0.000
J18.9 Pneumonia, unspecified
0.719 0.281 0.000
H35.3 Degeneration of macula and posterior pole
0.719 0.281 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T79-T79 Certain early complications of trauma
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
T91.3 Sequelae of injury of spinal cord
0.717 0.283 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.717 0.283 0.000
N48.6 Balanitis xerotica obliterans
0.716 0.283 0.000
E27 Other disorders of adrenal gland
0.716 0.284 0.000
E13 Other specified diabetes mellitus
0.715 0.285 0.000
J41 Simple and mucopurulent chronic bronchitis
0.715 0.285 0.000
O85-O92 Complications predominantly related to the puerperium
0.714 0.286 0.000
N17.0 Acute renal failure with tubular necrosis
0.713 0.287 0.000
M50-M54 Other dorsopathies
0.712 0.288 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.711 0.289 0.000
K65-K67 Diseases of peritoneum
0.711 0.289 0.000
C80 Malignant neoplasm without specification of site
0.709 0.291 0.000
K56.7 Ileus, unspecified
0.707 0.293 0.000
N32.9 Bladder disorder, unspecified
0.707 0.293 0.000
K74 Fibrosis and cirrhosis of liver
0.705 0.295 0.000
E12 Malnutrition-related diabetes mellitus
0.704 0.296 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.704 0.296 0.000
H31 Other disorders of choroid
0.704 0.296 0.000
H30 Chorioretinal inflammation
0.704 0.296 0.000
S01.9 Open wound of head, part unspecified
0.701 0.299 0.000
N03.9 Unspecified
0.701 0.299 0.000
G54 Nerve root and plexus disorders
0.700 0.299 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.700 0.300 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.700 0.300 0.000
J60-J70 Lung diseases due to external agents
0.699 0.301 0.000
K70.3 Alcoholic cirrhosis of liver
0.698 0.302 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.698 0.302 0.000
D45 Polycythaemia vera
0.697 0.303 0.000
S08 Traumatic amputation of part of head
0.696 0.304 0.000
S07 Crushing injury of head
0.696 0.304 0.000
S04 Injury of cranial nerves
0.696 0.304 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.696 0.304 0.000
F99-F99 Unspecified mental disorder
0.696 0.304 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.695 0.305 0.000
E10.8 With unspecified complications
0.694 0.306 0.000
E10.7 With multiple complications
0.694 0.306 0.000
E10.6 With other specified complications
0.694 0.306 0.000
E10.0 With coma
0.694 0.306 0.000
S02 Fracture of skull and facial bones
0.693 0.307 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.692 0.308 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.691 0.308 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.691 0.309 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.691 0.309 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.691 0.309 0.000
F60-F69 Disorders of adult personality and behaviour
0.691 0.309 0.000
O80-O84 Delivery
0.691 0.309 0.000
N18.8 Other chronic renal failure
0.690 0.310 0.000
N18.2 Chronic kidney disease, stage 2
0.690 0.310 0.000
N18.1 Chronic kidney disease, stage 1
0.690 0.310 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.690 0.310 0.000
H74 Other disorders of middle ear and mastoid
0.689 0.311 0.000
T95 Sequelae of burns, corrosions and frostbite
0.689 0.311 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.689 0.311 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.689 0.311 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.689 0.311 0.000
H33.4 Traction detachment of retina
0.689 0.311 0.000
H33.1 Retinoschisis and retinal cysts
0.689 0.311 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.689 0.311 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.688 0.312 0.000
E50-E64 Other nutritional deficiencies
0.687 0.313 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.687 0.313 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.686 0.314 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.686 0.314 0.000
J95-J99 Other diseases of the respiratory system
0.686 0.314 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.685 0.315 0.000
A30-A49 Other bacterial diseases
0.684 0.316 0.000
G95.1 Vascular myelopathies
0.684 0.316 0.000
S82.8 Fractures of other parts of lower leg
0.683 0.317 0.000
C15 Malignant neoplasm of oesophagus
0.683 0.317 0.000
S01.0 Open wound of scalp
0.682 0.318 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.682 0.318 0.000
E11.1 With ketoacidosis
0.681 0.319 0.000
E40-E46 Malnutrition
0.680 0.320 0.000
H53-H54 Visual disturbances and blindness
0.680 0.320 0.000
S01.2 Open wound of nose
0.679 0.321 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.679 0.321 0.000
H73 Other disorders of tympanic membrane
0.679 0.321 0.000
G95.9 Disease of spinal cord, unspecified
0.677 0.323 0.000
E66.8 Other obesity
0.677 0.323 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.676 0.324 0.000
G58 Other mononeuropathies
0.675 0.325 0.000
G91 Hydrocephalus
0.675 0.325 0.000
G43.8 Other migraine
0.675 0.325 0.000
F33 Recurrent depressive disorder
0.675 0.325 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.675 0.325 0.000
S92 Fracture of foot, except ankle
0.674 0.326 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.673 0.327 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.673 0.327 0.000
F01 Vascular dementia
0.672 0.328 0.000
S01.7 Multiple open wounds of head
0.672 0.328 0.000
S01.4 Open wound of cheek and temporomandibular area
0.672 0.328 0.000
G25 Other extrapyramidal and movement disorders
0.671 0.329 0.000
Chapter IX Diseases of the circulatory system
0.671 0.329 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.671 0.329 0.000
F70-F79 Mental retardation
0.671 0.329 0.000
N32.1 Vesicointestinal fistula
0.670 0.330 0.000
S60-S69 Injuries to the wrist and hand
0.670 0.330 0.000
K56.5 Intestinal adhesions [bands] with obstruction
0.668 0.332 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.668 0.332 0.000
C16.9 Stomach, unspecified
0.668 0.332 0.000
F03 Unspecified dementia
0.668 0.332 0.000
S40 Superficial injury of shoulder and upper arm
0.667 0.333 0.000
H33.5 Other retinal detachments
0.667 0.333 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.667 0.333 0.000
N42 Other disorders of prostate
0.667 0.333 0.000
S27 Injury of other and unspecified intrathoracic organs
0.667 0.333 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.666 0.334 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.666 0.334 0.000
J43.9 Emphysema, unspecified
0.666 0.334 0.000
Q80-Q89 Other congenital malformations
0.664 0.335 0.000
S70 Superficial injury of hip and thigh
0.663 0.337 0.000
E65 Localised adiposity
0.663 0.337 0.000
S06.3 Focal brain injury
0.663 0.337 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.663 0.337 0.000
J11 Influenza, virus not identified
0.662 0.338 0.000
G95.2 Cord compression, unspecified
0.662 0.338 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.662 0.338 0.000
G52 Disorders of other cranial nerves
0.662 0.338 0.000
T81 Complications of procedures, not elsewhere classified
0.661 0.339 0.000
T87 Complications peculiar to reattachment and amputation
0.661 0.339 0.000
I95 Hypotension
0.661 0.339 0.000
T86.1 Kidney transplant failure and rejection
0.661 0.339 0.000
S52.5 Fracture of lower end of radius
0.661 0.339 0.000
H80-H83 Diseases of inner ear
0.661 0.339 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.660 0.340 0.000
H65 Nonsuppurative otitis media
0.659 0.341 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.659 0.341 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.659 0.341 0.000
S90 Superficial injury of ankle and foot
0.659 0.341 0.000
Q60-Q64 Congenital malformations of the urinary system
0.658 0.342 0.000
N64 Other disorders of breast
0.657 0.342 0.000
K83 Other diseases of biliary tract
0.658 0.342 0.000
F20 Schizophrenia
0.657 0.343 0.000
E00-E07 Disorders of thyroid gland
0.657 0.343 0.000
M54 Dorsalgia
0.657 0.343 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.656 0.344 0.000
G50 Disorders of trigeminal nerve
0.656 0.344 0.000
N25-N29 Other disorders of kidney and ureter
0.656 0.344 0.000
K82 Other diseases of gallbladder
0.656 0.344 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.654 0.345 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.654 0.346 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.654 0.346 0.000
H05 Disorders of orbit
0.654 0.346 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.654 0.346 0.000
N17.8 Other acute renal failure
0.654 0.346 0.000
N17.2 Acute renal failure with medullary necrosis
0.654 0.346 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.654 0.346 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.651 0.349 0.000
N06 Isolated proteinuria with specified morphological lesion
0.651 0.349 0.000
N01 Rapidly progressive nephritic syndrome
0.651 0.349 0.000
N00 Acute nephritic syndrome
0.651 0.349 0.000
E70-E90 Metabolic disorders
0.650 0.350 0.000
J17 Pneumonia in diseases classified elsewhere
0.648 0.352 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.648 0.352 0.000
J12 Viral pneumonia, not elsewhere classified
0.648 0.352 0.000
J10 Influenza due to identified influenza virus
0.648 0.352 0.000
J14 Pneumonia due to Haemophilus influenzae
0.648 0.352 0.000
J09 Influenza due to certain identified influenza virus
0.648 0.352 0.000
E11.2 With renal complications
0.648 0.352 0.000
Q00-Q07 Congenital malformations of the nervous system
0.648 0.352 0.000
N48.9 Disorder of penis, unspecified
0.648 0.352 0.000
J30 Vasomotor and allergic rhinitis
0.647 0.353 0.000
T91.5 Sequelae of injury of intra-abdominal and pelvic organs
0.647 0.353 0.000
T91.4 Sequelae of injury of intrathoracic organs
0.647 0.353 0.000
T91.2 Sequelae of other fracture of thorax and pelvis
0.647 0.353 0.000
T91.1 Sequelae of fracture of spine
0.647 0.353 0.000
T91.0 Sequelae of superficial injury and open wound of neck and trunk
0.647 0.353 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.647 0.353 0.000
N13 Obstructive and reflux uropathy
0.647 0.353 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.647 0.353 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.646 0.354 0.000
M45-M49 Spondylopathies
0.645 0.355 0.000
C67 Malignant neoplasm of bladder
0.645 0.355 0.000
G95.8 Other specified diseases of spinal cord
0.645 0.355 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.644 0.356 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.644 0.356 0.000
G90 Disorders of autonomic nervous system
0.644 0.356 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.644 0.356 0.000
G92 Toxic encephalopathy
0.644 0.356 0.000
C50 Malignant neoplasm of breast
0.644 0.356 0.000
S86 Injury of muscle and tendon at lower leg level
0.643 0.357 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.643 0.357 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.643 0.357 0.000
J40 Bronchitis, not specified as acute or chronic
0.642 0.357 0.000
S52.6 Fracture of lower end of both ulna and radius
0.642 0.358 0.000
C45 Mesothelioma
0.641 0.358 0.000
G47 Sleep disorders
0.641 0.359 0.000
R79 Other abnormal findings of blood chemistry
0.641 0.359 0.000
H02.6 Xanthelasma of eyelid
0.641 0.359 0.000
S22.0 Fracture of thoracic vertebra
0.640 0.360 0.000
S52.1 Fracture of upper end of radius
0.640 0.360 0.000
S12 Fracture of neck
0.640 0.360 0.000
N48.2 Other inflammatory disorders of penis
0.640 0.360 0.000
F00 Dementia in Alzheimer's disease
0.638 0.362 0.000
K77 Liver disorders in diseases classified elsewhere
0.638 0.362 0.000
K73 Chronic hepatitis, not elsewhere classified
0.638 0.362 0.000
K71 Toxic liver disease
0.638 0.362 0.000
S51 Open wound of forearm
0.638 0.362 0.000
N10 Acute tubulo-interstitial nephritis
0.638 0.362 0.000
I95.9 Hypotension, unspecified
0.638 0.362 0.000
S06.0 Concussion
0.637 0.363 0.000
H33.2 Serous retinal detachment
0.636 0.364 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.636 0.364 0.000
M50 Cervical disk disorders
0.635 0.365 0.000
I95.1 Orthostatic hypotension
0.635 0.365 0.000
D46 Myelodysplastic syndromes
0.634 0.366 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.634 0.366 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.634 0.366 0.000
Q35-Q37 Cleft lip and cleft palate
0.634 0.366 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.634 0.366 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.634 0.366 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.634 0.366 0.000
G41 Status epilepticus
0.634 0.366 0.000
H34.2 Other retinal artery occlusions
0.634 0.366 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.633 0.366 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.633 0.367 0.000
E27.1 Primary adrenocortical insufficiency
0.633 0.367 0.000
K86 Other diseases of pancreas
0.633 0.367 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.632 0.368 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.632 0.368 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.632 0.368 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.632 0.368 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.631 0.369 0.000
N46 Male infertility
0.631 0.369 0.000
N44 Torsion of testis
0.631 0.369 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.631 0.369 0.000
S19 Other and unspecified injuries of neck
0.630 0.370 0.000
F25 Schizoaffective disorders
0.630 0.370 0.000
K55 Vascular disorders of intestine
0.629 0.371 0.000
H72 Perforation of tympanic membrane
0.629 0.371 0.000
S01.5 Open wound of lip and oral cavity
0.629 0.371 0.000
C21 Malignant neoplasm of anus and anal canal
0.629 0.371 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.628 0.372 0.000
O02 Other abnormal products of conception
0.628 0.372 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.627 0.373 0.000
K76.7 Hepatorenal syndrome
0.627 0.373 0.000
K76.5 Hepatic veno-occlusive disease
0.627 0.373 0.000
K76.4 Peliosis hepatis
0.627 0.373 0.000
K76.3 Infarction of liver
0.627 0.373 0.000
K76.2 Central haemorrhagic necrosis of liver
0.627 0.373 0.000
K76.1 Chronic passive congestion of liver
0.627 0.373 0.000
N37 Urethral disorders in diseases classified elsewhere
0.626 0.374 0.000
N34 Urethritis and urethral syndrome
0.626 0.374 0.000
N33 Bladder disorders in diseases classified elsewhere
0.626 0.374 0.000
O15 Eclampsia
0.626 0.374 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.626 0.374 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.626 0.374 0.000
S80 Superficial injury of lower leg
0.626 0.374 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.626 0.374 0.000
J91 Pleural effusion in conditions classified elsewhere
0.625 0.375 0.000
S59 Other and unspecified injuries of forearm
0.625 0.375 0.000
S58 Traumatic amputation of forearm
0.625 0.375 0.000
S57 Crushing injury of forearm
0.625 0.375 0.000
S56 Injury of muscle and tendon at forearm level
0.625 0.375 0.000
S55 Injury of blood vessels at forearm level
0.625 0.375 0.000
S54 Injury of nerves at forearm level
0.625 0.375 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.625 0.375 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.624 0.375 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.624 0.376 0.000
H02.2 Lagophthalmos
0.624 0.376 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.624 0.376 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.624 0.376 0.000
G96 Other disorders of central nervous system
0.623 0.376 0.000
S05.8 Other injuries of eye and orbit
0.623 0.376 0.000
N04 Nephrotic syndrome
0.623 0.377 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.623 0.377 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.623 0.377 0.000
N43 Hydrocele and spermatocele
0.623 0.377 0.000
S29 Other and unspecified injuries of thorax
0.623 0.377 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.623 0.377 0.000
S26 Injury of heart
0.623 0.377 0.000
S25 Injury of blood vessels of thorax
0.623 0.377 0.000
S24 Injury of nerves and spinal cord at thorax level
0.623 0.377 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.623 0.377 0.000
S21 Open wound of thorax
0.623 0.377 0.000
G35 Multiple sclerosis
0.621 0.379 0.000
N32.4 Rupture of bladder, nontraumatic
0.621 0.379 0.000
N32.2 Vesical fistula, not elsewhere classified
0.621 0.379 0.000
J92 Pleural plaque
0.621 0.379 0.000
J36 Peritonsillar abscess
0.621 0.379 0.000
H36.0 Diabetic retinopathy
0.620 0.380 0.000
K70.0 Alcoholic fatty liver
0.620 0.380 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.620 0.380 0.000
C50.4 Upper-outer quadrant of breast
0.620 0.380 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.620 0.380 0.000
G56.2 Lesion of ulnar nerve
0.619 0.381 0.000
S01.1 Open wound of eyelid and periocular area
0.619 0.381 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.618 0.382 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.618 0.382 0.000
H35.6 Retinal haemorrhage
0.618 0.382 0.000
E67 Other hyperalimentation
0.618 0.382 0.000
E68 Sequelae of hyperalimentation
0.618 0.382 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.617 0.382 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.617 0.382 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.617 0.382 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.617 0.382 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.617 0.382 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.617 0.382 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.617 0.383 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.617 0.383 0.000
H20.8 Other iridocyclitis
0.616 0.383 0.000
J94 Other pleural conditions
0.616 0.383 0.000
K56.3 Gallstone ileus
0.616 0.384 0.000
K56.0 Paralytic ileus
0.616 0.384 0.000
F81 Specific developmental disorders of scholastic skills
0.616 0.384 0.000
S82.4 Fracture of fibula alone
0.615 0.384 0.000
H16 Keratitis
0.615 0.384 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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