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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Diagnostic term associations

Hospitalization Episode Statistics (HES)

I35.1
Aortic (valve) insufficiency
Parent term
I35 Nonrheumatic aortic valve disorders
What are diagnostic terms?
Variant effects

Click on a variant to see its association results.

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Genome-wide   Chromosomes: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Results table
Variant Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
rs9984110 lBF = 5.56   Chr21 : 31,447,366
0.919 0.081 0.000
rs869708 lBF = 14.092   Chr21 : 46,434,954
0.838 0.162 0.000
rs150097632 lBF = 16.4138   Chr21 : 40,688,518
0.790 0.210 0.000
rs113512172 lBF = 16.4938   Chr21 : 32,718,685
0.717 0.283 0.000
rs62237594 lBF = 13.6107   Chr21 : 41,465,664
0.714 0.286 0.000
rs113040104 lBF = 11.1608   Chr21 : 24,412,633
0.698 0.302 0.000
rs117887431 lBF = 13.1882   Chr21 : 43,679,123
0.647 0.353 0.000
rs112308695 lBF = 21.2781   Chr21 : 18,297,682
0.602 0.397 0.000
rs62235665 lBF = 13.4781   Chr21 : 41,534,335
0.601 0.399 0.000
rs76287751 lBF = 15.4167   Chr21 : 22,696,657
0.595 0.405 0.000
rs17004598 lBF = 2.6091   Chr21 : 45,078,556
0.554 0.446 0.000
rs17744121 lBF = 5.69352   Chr21 : 30,713,598
0.538 0.462 0.000
rs34308307 lBF = 7.33618   Chr21 : 46,620,730
0.537 0.463 0.000
rs116990435 lBF = 16.0291   Chr21 : 42,048,274
0.517 0.483 0.000
rs10439884 lBF = 5.61662   Chr21 : 10,971,951
0.516 0.484 0.000
rs11088859 lBF = 14.6883   Chr21 : 22,689,344
0.510 0.489 0.000
rs1899875 lBF = 15.3034   Chr21 : 22,669,522
0.479 0.521 0.000
rs76276670 lBF = 38.5052   Chr21 : 30,505,980
0.415 0.585 0.000
rs17272021 lBF = 15.6568   Chr21 : 47,491,937
0.406 0.594 0.000
rs77292666 lBF = 7.58228   Chr21 : 33,214,050
0.361 0.638 0.000
rs117903119 lBF = 9.06456   Chr21 : 46,716,223
0.346 0.654 0.000
rs16998084 lBF = 5.36261   Chr21 : 42,471,628
0.342 0.658 0.000
rs74203920 lBF = 13.9618   Chr21 : 45,714,294
0.336 0.664 0.000
rs7283054 lBF = 1.12404   Chr21 : 31,519,307
0.330 0.670 0.000
rs7277179 lBF = 15.5832   Chr21 : 30,758,760
0.328 0.671 0.000
rs8131653 lBF = 1.50705   Chr21 : 45,644,684
0.300 0.700 0.000
rs77851248 lBF = 21.7911   Chr21 : 24,570,193
0.298 0.701 0.000
rs111409535 lBF = 18.5218   Chr21 : 30,790,390
0.286 0.713 0.001
rs17750460 lBF = 8.95898   Chr21 : 30,745,615
0.261 0.739 0.000
rs117883435 lBF = 14.5495   Chr21 : 27,788,794
0.252 0.747 0.001
rs201564772 lBF = 17.1704   Chr21 : 17,774,632
0.197 0.802 0.000
rs7275212 lBF = 2.94756   Chr21 : 39,852,551
0.193 0.807 0.000
rs117124364 lBF = 1.90172   Chr21 : 34,369,761
0.187 0.813 0.000
rs34484155 lBF = 9.50363   Chr21 : 30,598,750
0.148 0.850 0.002
rs35724370 lBF = 16.3571   Chr21 : 29,751,778
0.117 0.883 0.000
rs71319465 lBF = 15.9195   Chr21 : 29,795,538
0.107 0.893 0.000
rs73185805 lBF = 2.62597   Chr21 : 28,141,810
0.096 0.904 0.000
rs112643338 lBF = 0.293833   Chr21 : 20,128,909
0.095 0.905 0.000
rs17229494 lBF = 5.20366   Chr21 : 38,928,100
0.068 0.932 0.000
rs234714 lBF = -0.0455752   Chr21 : 44,488,033
0.000 0.948 0.052
rs77600076 lBF = 5.41577   Chr21 : 19,531,442
0.047 0.953 0.000
rs111892515 lBF = 12.0702   Chr21 : 23,392,906
0.035 0.965 0.000
rs117270429 lBF = 18.3316   Chr21 : 38,124,803
0.020 0.980 0.000
rs2268241 lBF = 0.401969   Chr21 : 34,781,050
0.000 0.982 0.018
rs2833197 lBF = 0.0509782   Chr21 : 32,407,116
0.017 0.983 0.000
rs117069376 lBF = 9.48441   Chr21 : 19,995,322
0.016 0.984 0.000
rs74276156 lBF = 14.6764   Chr21 : 37,842,165
0.009 0.990 0.001
rs4148087 lBF = 0.00420442   Chr21 : 43,622,267
0.000 0.992 0.008
rs2829949 lBF = 8.60682   Chr21 : 27,222,822
0.008 0.992 0.000
rs45430 lBF = 0.51098   Chr21 : 42,746,081
0.007 0.993 0.000
rs220299 lBF = 0.00177075   Chr21 : 43,502,762
0.000 0.993 0.007
rs118136136 lBF = 2.24787   Chr21 : 35,274,965
0.006 0.993 0.000
rs1805128 lBF = 7.21284   Chr21 : 35,821,680
0.006 0.994 0.000
rs1789953 lBF = -0.0666517   Chr21 : 44,482,936
0.005 0.995 0.000
rs16992204 lBF = 0.00737991   Chr21 : 36,111,201
0.005 0.995 0.000
rs9305339 lBF = -0.0168166   Chr21 : 29,275,627
0.000 0.996 0.004
rs55706246 lBF = 2.16084   Chr21 : 35,595,637
0.000 0.996 0.004
rs9984974 lBF = -0.0498674   Chr21 : 37,809,377
0.004 0.996 0.000
rs78211511 lBF = 0.00428967   Chr21 : 17,562,284
0.003 0.997 0.000
rs2823752 lBF = 12.8636   Chr21 : 17,717,125
0.003 0.997 0.000
rs2826762 lBF = 7.61206   Chr21 : 22,649,414
0.002 0.998 0.000
rs10470209 lBF = 9.26221   Chr21 : 20,110,007
0.002 0.998 0.000
rs9978142 lBF = 9.28145   Chr21 : 35,652,239
0.002 0.998 0.000
rs9976946 lBF = -0.00652189   Chr21 : 36,208,062
0.002 0.998 0.000
rs9975325 lBF = 0.0364471   Chr21 : 29,691,222
0.002 0.998 0.000
rs75884327 lBF = -0.035947   Chr21 : 40,491,320
0.000 0.998 0.002
rs2834812 lBF = 1.53993   Chr21 : 36,533,662
0.002 0.998 0.000
rs2851391 lBF = -0.0762453   Chr21 : 44,487,404
0.000 0.998 0.002
rs62221577 lBF = 8.78053   Chr21 : 33,164,508
0.002 0.998 0.000
rs77335750 lBF = 14.1372   Chr21 : 37,579,120
0.001 0.998 0.000
rs8127967 lBF = 12.6191   Chr21 : 21,763,036
0.001 0.998 0.000
rs62229266 lBF = 0.39816   Chr21 : 37,460,271
0.000 0.999 0.001
rs12483148 lBF = -0.077018   Chr21 : 37,013,621
0.000 0.999 0.001
rs16991453 lBF = 12.1322   Chr21 : 35,647,104
0.001 0.999 0.000
rs6517147 lBF = 0.281921   Chr21 : 34,542,787
0.000 0.999 0.001
rs2834435 lBF = 11.0645   Chr21 : 35,647,853
0.001 0.999 0.000
rs2833991 lBF = -0.0236283   Chr21 : 34,262,687
0.000 0.999 0.001
rs8129913 lBF = -0.0599569   Chr21 : 27,064,339
0.000 0.999 0.001
rs16993221 lBF = 0.0000877   Chr21 : 36,849,419
0.001 0.999 0.000
rs73194058 lBF = 0.00304808   Chr21 : 34,764,288
0.000 0.999 0.001
rs4293630 lBF = -0.0400741   Chr21 : 47,445,791
0.001 0.999 0.000
rs2154490 lBF = -0.0662055   Chr21 : 30,915,962
0.001 0.999 0.000
rs7275460 lBF = 9.35732   Chr21 : 41,447,058
0.001 0.999 0.000
rs16999204 lBF = 7.39147   Chr21 : 41,416,066
0.001 0.999 0.000
rs1013063 lBF = 0.137067   Chr21 : 35,698,390
0.000 0.999 0.001
rs9974878 lBF = 11.6455   Chr21 : 35,642,446
0.001 0.999 0.000
rs189677472 lBF = 0   Chr21 : 44,061,212
0.001 0.999 0.001
rs142181472 lBF = 0   Chr21 : 28,860,237
0.001 0.999 0.001
rs75030518 lBF = 0   Chr21 : 36,313,784
0.001 0.999 0.001
rs142976294 lBF = 0   Chr21 : 28,927,121
0.001 0.999 0.001
rs141838403 lBF = 0   Chr21 : 28,890,426
0.001 0.999 0.001
rs142429672 lBF = 0   Chr21 : 28,885,691
0.001 0.999 0.001
rs139916902 lBF = 0   Chr21 : 28,842,080
0.001 0.999 0.001
rs186825689 lBF = 0   Chr21 : 48,006,053
0.001 0.999 0.001
rs139202427 lBF = 0   Chr21 : 28,917,934
0.001 0.999 0.001
rs7279441 lBF = -0.0493456   Chr21 : 24,198,815
0.000 0.999 0.001
rs147130662 lBF = 0.00000084   Chr21 : 28,830,255
0.001 0.999 0.000
rs4148112 lBF = -0.00001042   Chr21 : 43,650,776
0.001 0.999 0.000
rs1735884 lBF = -0.107025   Chr21 : 21,820,408
0.001 0.999 0.000
rs9982601 lBF = 30.0006   Chr21 : 35,599,128
0.001 0.999 0.000
rs643608 lBF = -0.00745327   Chr21 : 44,768,562
0.000 0.999 0.001
rs4818184 lBF = -0.0557485   Chr21 : 42,202,431
0.000 0.999 0.001
rs17227203 lBF = 5.66998   Chr21 : 36,415,707
0.000 0.999 0.001
rs242364 lBF = 0.0481487   Chr21 : 28,890,132
0.001 0.999 0.000
rs2409317 lBF = -0.00559775   Chr21 : 30,074,424
0.000 0.999 0.001
rs9979250 lBF = 0.727665   Chr21 : 40,283,733
0.000 0.999 0.001
rs79978308 lBF = 2.78083   Chr21 : 41,020,545
0.001 0.999 0.000
rs9983044 lBF = -0.0109852   Chr21 : 36,416,332
0.001 0.999 0.000
rs9980664 lBF = -0.021529   Chr21 : 34,734,510
0.001 0.999 0.000
rs8128234 lBF = 0.43771   Chr21 : 36,470,865
0.001 0.999 0.000
rs138755414 lBF = 0.01086   Chr21 : 29,676,670
0.000 0.999 0.000
rs12483205 lBF = 0.304471   Chr21 : 38,740,824
0.000 0.999 0.001
rs496300 lBF = -0.04852   Chr21 : 44,779,680
0.000 0.999 0.001
rs9284510 lBF = 6.78234   Chr21 : 47,557,074
0.000 0.999 0.000
rs451390 lBF = -0.00398124   Chr21 : 43,343,510
0.000 0.999 0.000
rs3827268 lBF = 5.10531   Chr21 : 47,350,010
0.000 0.999 0.000
rs3788013 lBF = -0.0145564   Chr21 : 43,841,328
0.001 0.999 0.000
rs2833610 lBF = 0.160939   Chr21 : 33,385,186
0.001 0.999 0.000
rs61550741 lBF = -0.00079435   Chr21 : 32,506,284
0.001 0.999 0.000
rs2834431 lBF = 9.37156   Chr21 : 35,644,228
0.001 0.999 0.000
rs2154427 lBF = 0.0278154   Chr21 : 34,168,573
0.000 0.999 0.001
rs117802660 lBF = 15.852   Chr21 : 27,198,954
0.000 0.999 0.001
rs915832 lBF = -0.0845599   Chr21 : 43,275,495
0.001 0.999 0.000
rs145672791 lBF = 0.0301724   Chr21 : 14,750,023
0.000 0.999 0.000
rs9976767 lBF = -0.0310062   Chr21 : 43,836,390
0.001 0.999 0.000
rs147991290 lBF = 0.0194318   Chr21 : 34,088,470
0.000 1.000 0.000
rs8134605 lBF = -0.00482388   Chr21 : 32,304,266
0.000 1.000 0.000
rs2284553 lBF = -0.0519589   Chr21 : 34,776,695
0.000 1.000 0.000
rs34026679 lBF = 10.6117   Chr21 : 27,248,814
0.000 1.000 0.000
rs16994508 lBF = 0.200751   Chr21 : 38,189,679
0.000 1.000 0.000
rs73199525 lBF = -0.0135623   Chr21 : 32,884,848
0.000 1.000 0.000
rs982274 lBF = 0.123226   Chr21 : 19,479,731
0.000 1.000 0.000
rs6586282 lBF = 0.0701648   Chr21 : 44,478,497
0.000 1.000 0.000
rs2832270 lBF = -0.034884   Chr21 : 30,594,532
0.000 1.000 0.000
rs2823819 lBF = -0.0470458   Chr21 : 17,828,291
0.000 1.000 0.000
rs459482 lBF = -0.106186   Chr21 : 42,793,791
0.000 1.000 0.000
rs9982672 lBF = 11.9641   Chr21 : 35,657,043
0.000 1.000 0.000
rs79158929 lBF = 11.5913   Chr21 : 35,682,958
0.000 1.000 0.000
rs1735151 lBF = 0.0406235   Chr21 : 41,123,301
0.000 1.000 0.000
rs6517329 lBF = -0.0517081   Chr21 : 37,481,477
0.000 1.000 0.000
rs78736162 lBF = -0.0326747   Chr21 : 42,740,488
0.000 1.000 0.000
rs8133932 lBF = -0.0830158   Chr21 : 47,211,085
0.000 1.000 0.000
rs16994935 lBF = 0.065828   Chr21 : 38,671,418
0.000 1.000 0.000
rs580140 lBF = -0.0342   Chr21 : 32,817,507
0.000 1.000 0.000
rs2205299 lBF = 0.129349   Chr21 : 18,206,630
0.000 1.000 0.000
rs57996174 lBF = 0.118538   Chr21 : 34,837,048
0.000 1.000 0.000
rs458685 lBF = -0.0625465   Chr21 : 31,177,511
0.000 1.000 0.000
Affx-17521858 lBF = 7.5796   Chr21 : 23,325,246
0.000 1.000 0.000
rs79985863 lBF = 0.0973103   Chr21 : 46,906,710
0.000 1.000 0.000
rs2839186 lBF = -0.00779405   Chr21 : 47,690,068
0.000 1.000 0.000
rs2834629 lBF = -0.0118618   Chr21 : 36,125,818
0.000 1.000 0.000
rs4819143 lBF = -0.0830092   Chr21 : 47,124,178
0.000 1.000 0.000
rs28451064 lBF = 42.9569   Chr21 : 35,593,827
0.000 1.000 0.000
rs73336408 lBF = 8.76344   Chr21 : 23,343,776
0.000 1.000 0.000
rs117589273 lBF = 5.16224   Chr21 : 46,992,250
0.000 1.000 0.000
rs2834442 lBF = 2.718   Chr21 : 35,690,786
0.000 1.000 0.000
rs2830840 lBF = -0.0316523   Chr21 : 28,665,347
0.000 1.000 0.000
rs78015114 lBF = -0.0344031   Chr21 : 20,312,612
0.000 1.000 0.000
rs112243387 lBF = 5.91351   Chr21 : 37,649,206
0.000 1.000 0.000
rs17001239 lBF = 0.0773098   Chr21 : 27,002,377
0.000 1.000 0.000
rs2150410 lBF = 0.0583735   Chr21 : 40,569,779
0.000 1.000 0.000
rs2826340 lBF = -0.00087214   Chr21 : 21,885,302
0.000 1.000 0.000
rs57126985 lBF = -0.0092976   Chr21 : 16,590,032
0.000 1.000 0.000
rs8127571 lBF = 0.0270023   Chr21 : 47,165,429
0.000 1.000 0.000
rs2838923 lBF = -0.0840258   Chr21 : 46,846,944
0.000 1.000 0.000
rs9978888 lBF = 8.12132   Chr21 : 18,002,476
0.000 1.000 0.000
rs2834215 lBF = 0.028894   Chr21 : 34,796,886
0.000 1.000 0.000
rs74795342 lBF = -0.0164899   Chr21 : 20,326,336
0.000 1.000 0.000
rs2823286 lBF = 0.148951   Chr21 : 16,817,938
0.000 1.000 0.000
rs363512 lBF = -0.00324042   Chr21 : 31,050,817
0.000 1.000 0.000
rs2836882 lBF = 15.1324   Chr21 : 40,466,570
0.000 1.000 0.000
rs2836883 lBF = 15.0723   Chr21 : 40,466,744
0.000 1.000 0.000
rs9808651 lBF = 14.9638   Chr21 : 40,466,468
0.000 1.000 0.000
rs1892700 lBF = 0.0127465   Chr21 : 35,016,137
0.000 1.000 0.000
rs234709 lBF = -0.0381838   Chr21 : 44,486,964
0.000 1.000 0.000
rs240444 lBF = -0.0457575   Chr21 : 11,002,011
0.000 1.000 0.000
rs4817986 lBF = 14.8584   Chr21 : 40,465,512
0.000 1.000 0.000
rs7276739 lBF = 7.64565   Chr21 : 35,588,864
0.000 1.000 0.000
rs11700808 lBF = 0.530252   Chr21 : 20,238,855
0.000 1.000 0.000
rs16978810 lBF = 0.22043   Chr21 : 47,488,332
0.000 1.000 0.000
rs1475591 lBF = -0.00289356   Chr21 : 32,440,540
0.000 1.000 0.000
rs28456019 lBF = -0.00475793   Chr21 : 32,401,130
0.000 1.000 0.000
rs9979235 lBF = 0.031391   Chr21 : 44,156,769
0.000 1.000 0.000
rs12483240 lBF = 0.00933915   Chr21 : 26,829,777
0.000 1.000 0.000
rs857551 lBF = -0.0317863   Chr21 : 44,829,992
0.000 1.000 0.000
rs11088872 lBF = -0.0384848   Chr21 : 23,033,104
0.000 1.000 0.000
rs219780 lBF = 6.95723   Chr21 : 37,833,307
0.000 1.000 0.000
rs13048019 lBF = 0.203771   Chr21 : 32,918,294
0.000 1.000 0.000
rs2839398 lBF = -0.00482842   Chr21 : 43,286,352
0.000 1.000 0.000
rs2837857 lBF = -0.0138956   Chr21 : 42,216,955
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs4818048 lBF = 1.46255   Chr21 : 40,908,952
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs2836878 lBF = 14.682   Chr21 : 40,465,534
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs2823053 lBF = -0.0542112   Chr21 : 16,465,149
0.000 1.000 0.000
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0.000 1.000 0.000
rs13046373 lBF = -0.10425   Chr21 : 32,060,490
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs2014300 lBF = -0.0544318   Chr21 : 36,357,861
0.000 1.000 0.000
rs881827 lBF = -0.0773203   Chr21 : 48,019,868
0.000 1.000 0.000
rs2836751 lBF = -0.0823765   Chr21 : 40,290,959
0.000 1.000 0.000
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0.000 1.000 0.000
rs2823779 lBF = 1.55455   Chr21 : 17,768,524
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs2839440 lBF = -0.0607027   Chr21 : 43,443,498
0.000 1.000 0.000
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0.000 1.000 0.000
rs2836754 lBF = -0.0832655   Chr21 : 40,291,740
0.000 1.000 0.000
rs2830487 lBF = -0.11195   Chr21 : 28,146,189
0.000 1.000 0.000
rs7279238 lBF = 6.50081   Chr21 : 43,092,206
0.000 1.000 0.000
rs34835292 lBF = 6.28298   Chr21 : 17,333,558
0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
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0.000 1.000 0.000
rs8133949 lBF = -0.0229439   Chr21 : 43,421,114
0.000 1.000 0.000
rs2836770 lBF = -0.0345351   Chr21 : 40,314,704
0.000 1.000 0.000
rs875125 lBF = -0.0368883   Chr21 : 46,129,686
0.000 1.000 0.000
rs2836823 lBF = -0.0591825   Chr21 : 40,380,249
0.000 1.000 0.000
rs1888414 lBF = -0.0725322   Chr21 : 21,777,730
0.000 1.000 0.000
rs67900830 lBF = -0.0864751   Chr21 : 44,615,872
0.000 1.000 0.000
rs11911275 lBF = -0.119655   Chr21 : 44,593,140
0.000 1.000 0.000
rs7281388 lBF = 6.02014   Chr21 : 47,398,647
0.000 1.000 0.000
rs8133843 lBF = 2.07497   Chr21 : 36,738,242
0.000 1.000 0.000
rs2836974 lBF = 1.76446   Chr21 : 40,663,181
0.000 1.000 0.000
rs1475911 lBF = 0.417681   Chr21 : 43,513,480
0.000 1.000 0.000
rs11700462 lBF = 0.0424012   Chr21 : 38,817,812
0.000 1.000 0.000
rs2055011 lBF = -0.00966066   Chr21 : 19,481,354
0.000 1.000 0.000
rs721146 lBF = -0.0395564   Chr21 : 25,913,239
0.000 1.000 0.000
rs2836425 lBF = -0.0525586   Chr21 : 39,838,825
0.000 1.000 0.000
rs7279297 lBF = -0.0697537   Chr21 : 43,227,915
0.000 1.000 0.000
rs2823743 lBF = -0.0732029   Chr21 : 17,667,720
0.000 1.000 0.000
rs2837253 lBF = -0.10686   Chr21 : 41,221,256
0.000 1.000 0.000
rs219776 lBF = 10.3337   Chr21 : 37,834,835
0.000 1.000 0.000
rs2823093 lBF = 4.00125   Chr21 : 16,520,832
0.000 1.000 0.000
rs7282490 lBF = 0.498175   Chr21 : 45,615,741
0.000 1.000 0.000
rs9982370 lBF = 0.04947   Chr21 : 39,865,855
0.000 1.000 0.000
rs9305354 lBF = -0.0136521   Chr21 : 29,475,196
0.000 1.000 0.000
rs9305406 lBF = -0.032338   Chr21 : 31,386,243
0.000 1.000 0.000
rs2833693 lBF = -0.0392987   Chr21 : 33,552,512
0.000 1.000 0.000
rs220262 lBF = -0.0546408   Chr21 : 43,482,046
0.000 1.000 0.000
rs2838088 lBF = -0.0551434   Chr21 : 43,092,201
0.000 1.000 0.000
rs2832077 lBF = -0.0553533   Chr21 : 30,141,021
0.000 1.000 0.000
rs2823962 lBF = -0.0606502   Chr21 : 18,046,232
0.000 1.000 0.000
rs2837828 lBF = -0.0717683   Chr21 : 42,174,960
0.000 1.000 0.000
rs1297258 lBF = 4.38603   Chr21 : 16,806,709
0.000 1.000 0.000
rs1736135 lBF = 4.38257   Chr21 : 16,805,220
0.000 1.000 0.000
rs1736020 lBF = 4.26685   Chr21 : 16,812,552
0.000 1.000 0.000
rs1297265 lBF = 4.21826   Chr21 : 16,817,051
0.000 1.000 0.000
rs2835345 lBF = 1.75696   Chr21 : 37,801,434
0.000 1.000 0.000
rs8127691 lBF = 1.52837   Chr21 : 45,614,860
0.000 1.000 0.000
rs762421 lBF = 1.4046   Chr21 : 45,615,561
0.000 1.000 0.000
rs2834188 lBF = 0.979999   Chr21 : 34,689,253
0.000 1.000 0.000
rs2838519 lBF = 0.725029   Chr21 : 45,615,023
0.000 1.000 0.000
rs2836326 lBF = 0.711281   Chr21 : 39,721,764
0.000 1.000 0.000
rs460214 lBF = 0.362655   Chr21 : 40,006,081
0.000 1.000 0.000
rs6517656 lBF = 0.277616   Chr21 : 42,583,738
0.000 1.000 0.000
rs441810 lBF = 0.234223   Chr21 : 42,698,907
0.000 1.000 0.000
rs2835810 lBF = 0.176405   Chr21 : 38,932,778
0.000 1.000 0.000
rs9984896 lBF = 0.10604   Chr21 : 37,935,669
0.000 1.000 0.000
rs455804 lBF = 0.045419   Chr21 : 31,146,169
0.000 1.000 0.000
rs1734920 lBF = 0.00379406   Chr21 : 41,344,911
0.000 1.000 0.000
rs2837960 lBF = -0.00220077   Chr21 : 42,511,918
0.000 1.000 0.000
rs9981861 lBF = -0.0218782   Chr21 : 41,415,044
0.000 1.000 0.000
rs2833607 lBF = -0.0373192   Chr21 : 33,381,040
0.000 1.000 0.000
rs1547374 lBF = -0.0571228   Chr21 : 43,778,895
0.000 1.000 0.000
rs2826659 lBF = -0.0731005   Chr21 : 22,487,854
0.000 1.000 0.000
rs2834902 lBF = -0.0783849   Chr21 : 36,688,528
0.000 1.000 0.000
rs2839619 lBF = -0.0807418   Chr21 : 44,436,177
0.000 1.000 0.000
rs234720 lBF = -0.0839953   Chr21 : 44,445,292
0.000 1.000 0.000
rs9305556 lBF = -0.0861211   Chr21 : 36,014,908
0.000 1.000 0.000
rs8127977 lBF = -0.0978804   Chr21 : 26,826,514
0.000 1.000 0.000
rs2410182 lBF = -0.121619   Chr21 : 41,180,076
0.000 1.000 0.000
rs2776353 lBF = 8.94721   Chr21 : 43,089,017
0.000 1.000 0.000
rs2242944 lBF = 7.22632   Chr21 : 40,465,178
0.000 1.000 0.000
rs2828478 lBF = 0.508575   Chr21 : 25,105,211
0.000 1.000 0.000
rs11088226 lBF = 0.133914   Chr21 : 33,925,531
0.000 1.000 0.000
rs2827025 lBF = 0.114049   Chr21 : 23,144,602
0.000 1.000 0.000
rs2226441 lBF = 0.0905002   Chr21 : 23,141,845
0.000 1.000 0.000
rs1041449 lBF = 0.0766488   Chr21 : 42,901,421
0.000 1.000 0.000
rs2833556 lBF = 0.00409185   Chr21 : 33,285,300
0.000 1.000 0.000
rs427943 lBF = -0.0176839   Chr21 : 46,570,896
0.000 1.000 0.000
rs222158 lBF = -0.031462   Chr21 : 27,872,161
0.000 1.000 0.000
rs1598848 lBF = -0.0344972   Chr21 : 28,946,276
0.000 1.000 0.000
rs4819388 lBF = -0.0644269   Chr21 : 45,647,421
0.000 1.000 0.000
rs2833522 lBF = -0.0667896   Chr21 : 33,179,371
0.000 1.000 0.000
rs2834655 lBF = -0.0675413   Chr21 : 36,238,507
0.000 1.000 0.000
rs2298450 lBF = -0.0708057   Chr21 : 37,623,447
0.000 1.000 0.000
rs11910494 lBF = -0.0751362   Chr21 : 33,296,113
0.000 1.000 0.000
rs2828785 lBF = -0.0789514   Chr21 : 25,437,505
0.000 1.000 0.000
rs2828520 lBF = -0.0847883   Chr21 : 25,143,119
0.000 1.000 0.000
rs2229741 lBF = -0.0954824   Chr21 : 16,340,289
0.000 1.000 0.000
rs425215 lBF = -0.100826   Chr21 : 43,707,101
0.000 1.000 0.000
rs363598 lBF = -0.102772   Chr21 : 31,013,159
0.000 1.000 0.000
rs4816890 lBF = -0.104407   Chr21 : 24,420,502
0.000 1.000 0.000
rs2823615 lBF = -0.116722   Chr21 : 17,483,133
0.000 1.000 0.000
rs2849691 lBF = 6.2942   Chr21 : 43,086,070
0.000 1.000 0.000
rs378108 lBF = 2.69278   Chr21 : 40,469,520
0.000 1.000 0.000
rs1893592 lBF = 1.92566   Chr21 : 43,855,067
0.000 1.000 0.000
rs11203203 lBF = 1.81255   Chr21 : 43,836,186
0.000 1.000 0.000
rs2836950 lBF = 0.735886   Chr21 : 40,604,429
0.000 1.000 0.000
rs914187 lBF = 0.12414   Chr21 : 42,619,749
0.000 1.000 0.000
rs743446 lBF = 0.0974998   Chr21 : 40,056,423
0.000 1.000 0.000
rs3787751 lBF = 0.0508496   Chr21 : 38,160,163
0.000 1.000 0.000
rs1209950 lBF = 0.0382876   Chr21 : 40,173,528
0.000 1.000 0.000
rs2838815 lBF = 0.0101966   Chr21 : 46,629,590
0.000 1.000 0.000
rs7435 lBF = -0.0303864   Chr21 : 45,404,338
0.000 1.000 0.000
rs2014791 lBF = -0.0600289   Chr21 : 23,145,950
0.000 1.000 0.000
rs2823357 lBF = -0.0652705   Chr21 : 16,914,905
0.000 1.000 0.000
rs10854398 lBF = -0.0749246   Chr21 : 41,021,752
0.000 1.000 0.000
rs1452093 lBF = -0.0754478   Chr21 : 28,744,356
0.000 1.000 0.000
rs2826891 lBF = -0.0771127   Chr21 : 22,910,116
0.000 1.000 0.000
rs9975851 lBF = -0.0786483   Chr21 : 27,716,654
0.000 1.000 0.000
rs9977499 lBF = -0.0810928   Chr21 : 28,734,997
0.000 1.000 0.000
rs9980603 lBF = -0.0946074   Chr21 : 41,886,583
0.000 1.000 0.000
rs9975691 lBF = -0.0954731   Chr21 : 14,928,355
0.000 1.000 0.000
rs2827312 lBF = -0.0971242   Chr21 : 23,631,676
0.000 1.000 0.000
rs372883 lBF = -0.112087   Chr21 : 30,717,737
0.000 1.000 0.000
rs7283316 lBF = -0.136982   Chr21 : 32,216,253
0.000 1.000 0.000

This table lists the top 335 variants ordered by p(effect).

The full results table can be downloaded from this page.

 
Variant clusters with highest protective effect

(posterior probability > 0.05)

Cluster X0112
log Bayes Factor = 98.8923
contains 7 variants
0.9978
Cluster X0096
log Bayes Factor = 8.06962
contains 1 variants
0.9963
Cluster X0090
log Bayes Factor = 11.7172
contains 2 variants
0.3658
Cluster X0335
log Bayes Factor = 12.3689
contains 1 variants
0.0608
Variant clusters with highest risk effect

(posterior probability > 0.05)

Cluster X0150
log Bayes Factor = 861.091
contains 26 variants
0.9999
Cluster X0124
log Bayes Factor = 336.468
contains 13 variants
0.9976
Cluster X0086
log Bayes Factor = 131.002
contains 8 variants
0.9960
Cluster X0028
log Bayes Factor = 120.445
contains 7 variants
0.9913
Cluster X0045
log Bayes Factor = 446.264
contains 16 variants
0.9910
Cluster X0146
log Bayes Factor = 686.343
contains 22 variants
0.9883
Cluster X0277
log Bayes Factor = 726.213
contains 23 variants
0.9879
Cluster X0073
log Bayes Factor = 785.614
contains 25 variants
0.9874
Cluster X0152
log Bayes Factor = 331.156
contains 10 variants
0.9849
Cluster X0171
log Bayes Factor = 291.293
contains 14 variants
0.9848
Cluster X0142
log Bayes Factor = 295.63
contains 12 variants
0.9833
Cluster X0039
log Bayes Factor = 463.231
contains 17 variants
0.9800
Cluster X0237
log Bayes Factor = 123.902
contains 6 variants
0.9751
Cluster X0098
log Bayes Factor = 246.226
contains 8 variants
0.9715
Cluster X0054
log Bayes Factor = 197.338
contains 9 variants
0.9713
Cluster X0290
log Bayes Factor = 333.908
contains 13 variants
0.9679
Cluster X0077
log Bayes Factor = 571.533
contains 17 variants
0.9676
Cluster X0307
log Bayes Factor = 826.86
contains 2 variants
0.9675
Cluster X0118
log Bayes Factor = 91.1908
contains 5 variants
0.9600
Cluster X0109
log Bayes Factor = 257.685
contains 11 variants
0.9580
Cluster X0140
log Bayes Factor = 164.536
contains 8 variants
0.9479
Cluster X0083
log Bayes Factor = 351.917
contains 13 variants
0.9468
Cluster X0161
log Bayes Factor = 609.219
contains 20 variants
0.9407
Cluster X0212
log Bayes Factor = 300.777
contains 10 variants
0.9405
Cluster X0170
log Bayes Factor = 264.081
contains 11 variants
0.9343
Cluster X0203
log Bayes Factor = 363.522
contains 11 variants
0.9153
Cluster X0249
log Bayes Factor = 244.457
contains 11 variants
0.9139
Cluster X0271
log Bayes Factor = 256.743
contains 10 variants
0.9121
Cluster X0222
log Bayes Factor = 431.582
contains 17 variants
0.8971
Cluster X0243
log Bayes Factor = 104.974
contains 6 variants
0.8930
Cluster X0261
log Bayes Factor = 420.614
contains 20 variants
0.8739
Cluster X0258
log Bayes Factor = 104.851
contains 6 variants
0.8739
Cluster X0137
log Bayes Factor = 120.748
contains 4 variants
0.8737
Cluster X0165
log Bayes Factor = 303.727
contains 12 variants
0.8674
Cluster X0240
log Bayes Factor = 104.862
contains 6 variants
0.8491
Cluster X0155
log Bayes Factor = 348.568
contains 12 variants
0.8468
Cluster X0250
log Bayes Factor = 43.399
contains 4 variants
0.8344
Cluster X0238
log Bayes Factor = 97.9307
contains 4 variants
0.8173
Cluster X0139
log Bayes Factor = 304.555
contains 10 variants
0.8135
Cluster X0001
log Bayes Factor = 167.541
contains 7 variants
0.8023
Cluster X0014
log Bayes Factor = 131.677
contains 6 variants
0.8022
Cluster X0107
log Bayes Factor = 151.016
contains 1 variants
0.7216
Cluster X0229
log Bayes Factor = 347.165
contains 13 variants
0.7142
Cluster X0088
log Bayes Factor = 243.609
contains 9 variants
0.7091
Cluster X0044
log Bayes Factor = 1165.44
contains 34 variants
0.6942
Cluster X0268
log Bayes Factor = 213.591
contains 8 variants
0.6909
Cluster X0153
log Bayes Factor = 328.394
contains 11 variants
0.6610
Cluster X0085
log Bayes Factor = 138.902
contains 6 variants
0.6522
Cluster X0110
log Bayes Factor = 721.325
contains 13 variants
0.6471
Cluster X0213
log Bayes Factor = 405.918
contains 15 variants
0.6240
Cluster X0057
log Bayes Factor = 439.35
contains 16 variants
0.6060
Cluster X0156
log Bayes Factor = 226.954
contains 9 variants
0.5859
Cluster X0024
log Bayes Factor = 309.44
contains 13 variants
0.5505
Cluster X0019
log Bayes Factor = 372.36
contains 16 variants
0.4991
Cluster X0253
log Bayes Factor = 331.491
contains 13 variants
0.4963
Cluster X0093
log Bayes Factor = 289.878
contains 10 variants
0.4900
Cluster X0224
log Bayes Factor = 278.692
contains 11 variants
0.4779
Cluster X0120
log Bayes Factor = 79.6695
contains 4 variants
0.4772
Cluster X0095
log Bayes Factor = 179.348
contains 8 variants
0.4680
Cluster X0145
log Bayes Factor = 274.587
contains 11 variants
0.4487
Cluster X0166
log Bayes Factor = 230.746
contains 8 variants
0.4477
Cluster X0129
log Bayes Factor = 195.809
contains 7 variants
0.4462
Cluster X0055
log Bayes Factor = 274.911
contains 10 variants
0.4389
Cluster X0178
log Bayes Factor = 225.6
contains 9 variants
0.4334
Cluster X0091
log Bayes Factor = 303.64
contains 12 variants
0.4312
Cluster X0248
log Bayes Factor = 254.854
contains 10 variants
0.4194
Cluster X0189
log Bayes Factor = 149.681
contains 5 variants
0.4171
Cluster X0020
log Bayes Factor = 557.721
contains 18 variants
0.4107
Cluster X0071
log Bayes Factor = 131.269
contains 6 variants
0.3739
Cluster X0284
log Bayes Factor = 192.532
contains 9 variants
0.3684
Cluster X0012
log Bayes Factor = 112.432
contains 5 variants
0.3600
Cluster X0208
log Bayes Factor = 40.6733
contains 2 variants
0.3502
Cluster X0192
log Bayes Factor = 402.511
contains 14 variants
0.3422
Cluster X0326
log Bayes Factor = 112.92
contains 5 variants
0.3286
Cluster X0177
log Bayes Factor = 254.872
contains 10 variants
0.3266
Cluster X0194
log Bayes Factor = 189.9
contains 5 variants
0.2933
Cluster X0246
log Bayes Factor = 121.08
contains 5 variants
0.2922
Cluster X0102
log Bayes Factor = 99.5678
contains 5 variants
0.2616
Cluster X0214
log Bayes Factor = 186.582
contains 8 variants
0.2510
Cluster X0026
log Bayes Factor = 232.119
contains 9 variants
0.2491
Cluster X0003
log Bayes Factor = 195.6
contains 8 variants
0.2359
Cluster X0049
log Bayes Factor = 597.061
contains 18 variants
0.2331
Cluster X0122
log Bayes Factor = 219.114
contains 9 variants
0.2217
Cluster X0327
log Bayes Factor = 118.248
contains 3 variants
0.2194
Cluster X0043
log Bayes Factor = 517.108
contains 20 variants
0.2014
Cluster X0067
log Bayes Factor = 179.381
contains 8 variants
0.2000
Cluster X0205
log Bayes Factor = 674.183
contains 18 variants
0.1989
Cluster X0134
log Bayes Factor = 151.731
contains 8 variants
0.1875
Cluster X0051
log Bayes Factor = 376.793
contains 14 variants
0.1863
Cluster X0038
log Bayes Factor = 31.1234
contains 2 variants
0.1798
Cluster X0221
log Bayes Factor = 149.378
contains 10 variants
0.1730
Cluster X0264
log Bayes Factor = 205.833
contains 10 variants
0.1415
Cluster X0201
log Bayes Factor = 368.049
contains 13 variants
0.1365
Cluster X0280
log Bayes Factor = 86.0876
contains 1 variants
0.1320
Cluster X0220
log Bayes Factor = 142.284
contains 7 variants
0.1242
Cluster X0257
log Bayes Factor = 281.184
contains 10 variants
0.1228
Cluster X0094
log Bayes Factor = 562.956
contains 18 variants
0.1176
Cluster X0287
log Bayes Factor = 33.3095
contains 4 variants
0.1037
Cluster X0015
log Bayes Factor = 356.23
contains 15 variants
0.1034
Cluster X0322
log Bayes Factor = 70.0115
contains 3 variants
0.0977
Cluster X0225
log Bayes Factor = 36.4143
contains 3 variants
0.0942
Cluster X0259
log Bayes Factor = 246.237
contains 11 variants
0.0929
Cluster X0047
log Bayes Factor = 378.621
contains 14 variants
0.0858
Cluster X0188
log Bayes Factor = 222.629
contains 14 variants
0.0827
Cluster X0164
log Bayes Factor = 463.793
contains 16 variants
0.0729
Cluster X0157
log Bayes Factor = 172.957
contains 8 variants
0.0691
Cluster X0163
log Bayes Factor = 122.554
contains 6 variants
0.0579
Cluster X0231
log Bayes Factor = 82.3185
contains 5 variants
0.0547
 
 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

The contents of TreeWAS.org are available under the Creative Commons Attribution 4.0 International License (CC BY 4.0) with attribution (citation) required.

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