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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Diagnostic term associations

Hospitalization Episode Statistics (HES)

H46
Optic neuritis
Parent term
H46-H48 Disorders of optic nerve and visual pathways
What are diagnostic terms?
Variant effects

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Genome-wide   Chromosomes: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Results table
Variant Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
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0.800 0.200 0.000
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0.766 0.234 0.000
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0.698 0.302 0.000
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0.677 0.323 0.000
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0.665 0.335 0.000
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0.661 0.339 0.000
rs7001413 lBF = 5.40312   Chr8 : 75,010,233
0.655 0.345 0.000
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0.655 0.345 0.000
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0.654 0.346 0.000
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0.652 0.348 0.000
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0.649 0.351 0.000
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0.640 0.360 0.000
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0.624 0.376 0.000
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0.602 0.397 0.000
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0.591 0.408 0.000
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0.588 0.412 0.000
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0.587 0.412 0.000
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0.584 0.416 0.000
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0.582 0.418 0.000
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0.574 0.426 0.000
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0.574 0.426 0.000
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0.573 0.427 0.000
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0.571 0.429 0.000
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0.571 0.429 0.000
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0.569 0.431 0.000
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0.565 0.435 0.000
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0.560 0.440 0.000
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0.559 0.441 0.000
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0.547 0.452 0.000
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0.545 0.455 0.000
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0.536 0.464 0.000
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0.534 0.466 0.000
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0.530 0.470 0.000
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0.529 0.471 0.000
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0.528 0.472 0.000
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0.523 0.477 0.000
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0.517 0.483 0.000
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0.516 0.484 0.000
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0.514 0.486 0.000
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0.514 0.486 0.000
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0.514 0.486 0.000
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0.514 0.486 0.000
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0.513 0.486 0.000
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0.513 0.487 0.000
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0.513 0.487 0.000
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0.513 0.487 0.000
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0.513 0.487 0.000
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0.513 0.487 0.000
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0.512 0.487 0.000
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0.510 0.490 0.000
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0.509 0.491 0.000
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0.509 0.491 0.000
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0.507 0.493 0.000
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0.505 0.495 0.000
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0.503 0.497 0.000
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0.493 0.507 0.000
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0.484 0.515 0.000
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0.475 0.525 0.000
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0.472 0.528 0.000
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0.471 0.529 0.000
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0.471 0.529 0.000
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0.471 0.529 0.000
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0.460 0.539 0.000
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0.460 0.540 0.000
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0.460 0.540 0.000
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0.455 0.545 0.000
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0.449 0.551 0.000
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0.447 0.553 0.000
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0.445 0.555 0.000
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0.443 0.556 0.000
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0.436 0.564 0.000
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0.435 0.565 0.000
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0.429 0.571 0.000
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0.427 0.573 0.000
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0.423 0.576 0.000
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0.420 0.580 0.000
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0.408 0.591 0.000
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0.204 0.796 0.000
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rs1961102 lBF = -0.0915305   Chr8 : 103,932,845
0.000 0.999 0.001
rs11988906 lBF = -0.127211   Chr8 : 4,251,284
0.000 0.999 0.001
rs298182 lBF = 0.432076   Chr8 : 65,303,535
0.001 0.999 0.000
rs2584363 lBF = -0.0514426   Chr8 : 108,158,383
0.000 0.999 0.001
rs9918807 lBF = -0.0613929   Chr8 : 130,676,639
0.001 0.999 0.000
rs2738113 lBF = -0.0948756   Chr8 : 6,829,085
0.001 0.999 0.000
rs7830933 lBF = 0.0906278   Chr8 : 23,603,324
0.001 0.999 0.000
rs16902328 lBF = 0.0227453   Chr8 : 128,713,873
0.000 0.999 0.001
rs77913157 lBF = 0.00320006   Chr8 : 19,949,198
0.001 0.999 0.000
rs7463166 lBF = -0.0381616   Chr8 : 4,833,790
0.001 0.999 0.000
rs1550582 lBF = -0.0807562   Chr8 : 135,542,084
0.000 0.999 0.001
rs6469937 lBF = -0.0880785   Chr8 : 121,610,438
0.001 0.999 0.000
rs931812 lBF = -0.0890979   Chr8 : 101,919,321
0.000 0.999 0.001
rs10102164 lBF = 0.173184   Chr8 : 55,421,614
0.000 0.999 0.001
rs56677333 lBF = -0.00016109   Chr8 : 6,750,801
0.001 0.999 0.000
rs11985951 lBF = -0.01452   Chr8 : 20,592,509
0.000 0.999 0.001
rs55798256 lBF = -0.0624198   Chr8 : 94,303,801
0.000 0.999 0.000
rs6559140 lBF = -0.0639266   Chr8 : 6,152,919
0.000 0.999 0.001
rs4875598 lBF = -0.0982412   Chr8 : 5,461,753
0.001 0.999 0.000
rs10955961 lBF = -0.100956   Chr8 : 121,218,601
0.000 0.999 0.001
rs1870805 lBF = -0.10755   Chr8 : 140,995,243
0.001 0.999 0.000
rs73229090 lBF = 0.00150645   Chr8 : 27,442,127
0.001 0.999 0.000
rs7841806 lBF = -0.0900559   Chr8 : 140,335,814
0.001 0.999 0.000
rs11995572 lBF = 0.255395   Chr8 : 89,592,083
0.000 0.999 0.001
rs62505227 lBF = 0.222927   Chr8 : 40,287,249
0.001 0.999 0.000
rs36056951 lBF = -0.0362417   Chr8 : 139,965,798
0.000 0.999 0.001
rs978152 lBF = -0.0405618   Chr8 : 133,369,094
0.000 0.999 0.001
rs17669535 lBF = -0.0535021   Chr8 : 1,244,224
0.000 0.999 0.001

This table lists the top 500 variants ordered by p(effect).

The full results table can be downloaded from this page.

 
Variant clusters with highest protective effect

(posterior probability > 0.05)

Cluster X0329
log Bayes Factor = 21.7039
contains 2 variants
0.2971
Variant clusters with highest risk effect

(posterior probability > 0.05)

Cluster X0106
log Bayes Factor = 980.916
contains 30 variants
0.9869
Cluster X0146
log Bayes Factor = 686.343
contains 22 variants
0.9858
Cluster X0013
log Bayes Factor = 548.265
contains 23 variants
0.9792
Cluster X0057
log Bayes Factor = 439.35
contains 16 variants
0.9790
Cluster X0148
log Bayes Factor = 315.237
contains 11 variants
0.9780
Cluster X0044
log Bayes Factor = 1165.44
contains 34 variants
0.9777
Cluster X0020
log Bayes Factor = 557.721
contains 18 variants
0.9776
Cluster X0015
log Bayes Factor = 356.23
contains 15 variants
0.9700
Cluster X0053
log Bayes Factor = 218.825
contains 12 variants
0.9682
Cluster X0231
log Bayes Factor = 82.3185
contains 5 variants
0.9657
Cluster X0075
log Bayes Factor = 431.344
contains 16 variants
0.9587
Cluster X0150
log Bayes Factor = 861.091
contains 26 variants
0.9571
Cluster X0232
log Bayes Factor = 695.273
contains 23 variants
0.9473
Cluster X0072
log Bayes Factor = 1189.98
contains 37 variants
0.9421
Cluster X0069
log Bayes Factor = 519.392
contains 20 variants
0.9350
Cluster X0110
log Bayes Factor = 721.325
contains 13 variants
0.9264
Cluster X0142
log Bayes Factor = 295.63
contains 12 variants
0.9255
Cluster X0024
log Bayes Factor = 309.44
contains 13 variants
0.9247
Cluster X0086
log Bayes Factor = 131.002
contains 8 variants
0.9219
Cluster X0061
log Bayes Factor = 293.105
contains 15 variants
0.9178
Cluster X0051
log Bayes Factor = 376.793
contains 14 variants
0.9170
Cluster X0021
log Bayes Factor = 338.631
contains 13 variants
0.9164
Cluster X0274
log Bayes Factor = 454.783
contains 18 variants
0.9122
Cluster X0039
log Bayes Factor = 463.231
contains 17 variants
0.9088
Cluster X0029
log Bayes Factor = 709.102
contains 23 variants
0.9068
Cluster X0222
log Bayes Factor = 431.582
contains 17 variants
0.9046
Cluster X0152
log Bayes Factor = 331.156
contains 10 variants
0.9038
Cluster X0040
log Bayes Factor = 542.747
contains 16 variants
0.8990
Cluster X0091
log Bayes Factor = 303.64
contains 12 variants
0.8986
Cluster X0145
log Bayes Factor = 274.587
contains 11 variants
0.8967
Cluster X0259
log Bayes Factor = 246.237
contains 11 variants
0.8952
Cluster X0210
log Bayes Factor = 426.159
contains 17 variants
0.8939
Cluster X0261
log Bayes Factor = 420.614
contains 20 variants
0.8898
Cluster X0033
log Bayes Factor = 379.444
contains 13 variants
0.8831
Cluster X0157
log Bayes Factor = 172.957
contains 8 variants
0.8798
Cluster X0176
log Bayes Factor = 407.797
contains 14 variants
0.8782
Cluster X0019
log Bayes Factor = 372.36
contains 16 variants
0.8775
Cluster X0132
log Bayes Factor = 267.393
contains 11 variants
0.8752
Cluster X0078
log Bayes Factor = 203.49
contains 11 variants
0.8747
Cluster X0041
log Bayes Factor = 306.192
contains 14 variants
0.8719
Cluster X0043
log Bayes Factor = 517.108
contains 20 variants
0.8715
Cluster X0164
log Bayes Factor = 463.793
contains 16 variants
0.8660
Cluster X0258
log Bayes Factor = 104.851
contains 6 variants
0.8647
Cluster X0249
log Bayes Factor = 244.457
contains 11 variants
0.8619
Cluster X0139
log Bayes Factor = 304.555
contains 10 variants
0.8598
Cluster X0123
log Bayes Factor = 382.779
contains 14 variants
0.8596
Cluster X0094
log Bayes Factor = 562.956
contains 18 variants
0.8586
Cluster X0087
log Bayes Factor = 894.58
contains 26 variants
0.8579
Cluster X0201
log Bayes Factor = 368.049
contains 13 variants
0.8537
Cluster X0133
log Bayes Factor = 224.204
contains 11 variants
0.8519
Cluster X0050
log Bayes Factor = 397.79
contains 16 variants
0.8506
Cluster X0068
log Bayes Factor = 127.774
contains 6 variants
0.8469
Cluster X0059
log Bayes Factor = 922.497
contains 26 variants
0.8465
Cluster X0045
log Bayes Factor = 446.264
contains 16 variants
0.8416
Cluster X0042
log Bayes Factor = 307.243
contains 12 variants
0.8406
Cluster X0140
log Bayes Factor = 164.536
contains 8 variants
0.8401
Cluster X0049
log Bayes Factor = 597.061
contains 18 variants
0.8367
Cluster X0185
log Bayes Factor = 84.7127
contains 6 variants
0.8360
Cluster X0007
log Bayes Factor = 107.567
contains 7 variants
0.8350
Cluster X0165
log Bayes Factor = 303.727
contains 12 variants
0.8313
Cluster X0065
log Bayes Factor = 53.0717
contains 3 variants
0.8312
Cluster X0054
log Bayes Factor = 197.338
contains 9 variants
0.8293
Cluster X0026
log Bayes Factor = 232.119
contains 9 variants
0.8236
Cluster X0047
log Bayes Factor = 378.621
contains 14 variants
0.8232
Cluster X0076
log Bayes Factor = 310.928
contains 15 variants
0.8217
Cluster X0093
log Bayes Factor = 289.878
contains 10 variants
0.8209
Cluster X0275
log Bayes Factor = 219.726
contains 10 variants
0.8202
Cluster X0308
log Bayes Factor = 33.8955
contains 3 variants
0.8198
Cluster X0014
log Bayes Factor = 131.677
contains 6 variants
0.8166
Cluster X0161
log Bayes Factor = 609.219
contains 20 variants
0.8135
Cluster X0218
log Bayes Factor = 425.579
contains 18 variants
0.8095
Cluster X0124
log Bayes Factor = 336.468
contains 13 variants
0.8094
Cluster X0253
log Bayes Factor = 331.491
contains 13 variants
0.8092
Cluster X0100
log Bayes Factor = 730.252
contains 26 variants
0.8066
Cluster X0126
log Bayes Factor = 384.432
contains 15 variants
0.8029
Cluster X0073
log Bayes Factor = 785.614
contains 25 variants
0.8016
Cluster X0229
log Bayes Factor = 347.165
contains 13 variants
0.7992
Cluster X0290
log Bayes Factor = 333.908
contains 13 variants
0.7950
Cluster X0119
log Bayes Factor = 114.358
contains 6 variants
0.7939
Cluster X0052
log Bayes Factor = 654.387
contains 25 variants
0.7919
Cluster X0209
log Bayes Factor = 214.798
contains 8 variants
0.7905
Cluster X0214
log Bayes Factor = 186.582
contains 8 variants
0.7895
Cluster X0277
log Bayes Factor = 726.213
contains 23 variants
0.7889
Cluster X0070
log Bayes Factor = 421.182
contains 15 variants
0.7887
Cluster X0067
log Bayes Factor = 179.381
contains 8 variants
0.7863
Cluster X0111
log Bayes Factor = 403.183
contains 18 variants
0.7855
Cluster X0256
log Bayes Factor = 211.588
contains 9 variants
0.7850
Cluster X0181
log Bayes Factor = 141.396
contains 6 variants
0.7829
Cluster X0018
log Bayes Factor = 430.611
contains 18 variants
0.7819
Cluster X0248
log Bayes Factor = 254.854
contains 10 variants
0.7800
Cluster X0205
log Bayes Factor = 674.183
contains 18 variants
0.7799
Cluster X0271
log Bayes Factor = 256.743
contains 10 variants
0.7788
Cluster X0284
log Bayes Factor = 192.532
contains 9 variants
0.7776
Cluster X0177
log Bayes Factor = 254.872
contains 10 variants
0.7775
Cluster X0030
log Bayes Factor = 216.364
contains 9 variants
0.7740
Cluster X0213
log Bayes Factor = 405.918
contains 15 variants
0.7739
Cluster X0109
log Bayes Factor = 257.685
contains 11 variants
0.7724
Cluster X0083
log Bayes Factor = 351.917
contains 13 variants
0.7717
Cluster X0058
log Bayes Factor = 183.199
contains 8 variants
0.7682
Cluster X0082
log Bayes Factor = 496.905
contains 17 variants
0.7678
Cluster X0156
log Bayes Factor = 226.954
contains 9 variants
0.7663
Cluster X0005
log Bayes Factor = 282.915
contains 11 variants
0.7614
Cluster X0001
log Bayes Factor = 167.541
contains 7 variants
0.7488
Cluster X0276
log Bayes Factor = 187.108
contains 9 variants
0.7468
Cluster X0143
log Bayes Factor = 179.808
contains 8 variants
0.7460
Cluster X0163
log Bayes Factor = 122.554
contains 6 variants
0.7432
Cluster X0077
log Bayes Factor = 571.533
contains 17 variants
0.7419
Cluster X0028
log Bayes Factor = 120.445
contains 7 variants
0.7415
Cluster X0071
log Bayes Factor = 131.269
contains 6 variants
0.7401
Cluster X0162
log Bayes Factor = 144.479
contains 9 variants
0.7347
Cluster X0191
log Bayes Factor = 163.555
contains 8 variants
0.7335
Cluster X0227
log Bayes Factor = 249.287
contains 11 variants
0.7286
Cluster X0154
log Bayes Factor = 282.084
contains 12 variants
0.7266
Cluster X0293
log Bayes Factor = 169.051
contains 7 variants
0.7245
Cluster X0226
log Bayes Factor = 145.726
contains 8 variants
0.7243
Cluster X0204
log Bayes Factor = 169.796
contains 8 variants
0.7237
Cluster X0081
log Bayes Factor = 278.568
contains 10 variants
0.7230
Cluster X0220
log Bayes Factor = 142.284
contains 7 variants
0.7225
Cluster X0320
log Bayes Factor = 110.964
contains 6 variants
0.7173
Cluster X0153
log Bayes Factor = 328.394
contains 11 variants
0.7168
Cluster X0250
log Bayes Factor = 43.399
contains 4 variants
0.7165
Cluster X0192
log Bayes Factor = 402.511
contains 14 variants
0.7090
Cluster X0178
log Bayes Factor = 225.6
contains 9 variants
0.7074
Cluster X0174
log Bayes Factor = 214.209
contains 8 variants
0.7052
Cluster X0268
log Bayes Factor = 213.591
contains 8 variants
0.7048
Cluster X0055
log Bayes Factor = 274.911
contains 10 variants
0.6926
Cluster X0098
log Bayes Factor = 246.226
contains 8 variants
0.6836
Cluster X0032
log Bayes Factor = 255.737
contains 12 variants
0.6701
Cluster X0184
log Bayes Factor = 188.416
contains 8 variants
0.6649
Cluster X0224
log Bayes Factor = 278.692
contains 11 variants
0.6625
Cluster X0234
log Bayes Factor = 28.8983
contains 2 variants
0.6584
Cluster X0012
log Bayes Factor = 112.432
contains 5 variants
0.6579
Cluster X0118
log Bayes Factor = 91.1908
contains 5 variants
0.6505
Cluster X0095
log Bayes Factor = 179.348
contains 8 variants
0.6500
Cluster X0088
log Bayes Factor = 243.609
contains 9 variants
0.6424
Cluster X0155
log Bayes Factor = 348.568
contains 12 variants
0.6395
Cluster X0159
log Bayes Factor = 152.327
contains 7 variants
0.6192
Cluster X0062
log Bayes Factor = 68.7461
contains 4 variants
0.6190
Cluster X0180
log Bayes Factor = 410.88
contains 15 variants
0.6155
Cluster X0129
log Bayes Factor = 195.809
contains 7 variants
0.6085
Cluster X0107
log Bayes Factor = 151.016
contains 1 variants
0.6060
Cluster X0131
log Bayes Factor = 143.942
contains 8 variants
0.6016
Cluster X0141
log Bayes Factor = 742.063
contains 30 variants
0.5918
Cluster X0324
log Bayes Factor = 32.1341
contains 1 variants
0.5873
Cluster X0237
log Bayes Factor = 123.902
contains 6 variants
0.5844
Cluster X0037
log Bayes Factor = 171.712
contains 6 variants
0.5800
Cluster X0203
log Bayes Factor = 363.522
contains 11 variants
0.5790
Cluster X0127
log Bayes Factor = 276.004
contains 14 variants
0.5771
Cluster X0046
log Bayes Factor = 387.972
contains 16 variants
0.5765
Cluster X0244
log Bayes Factor = 122.647
contains 5 variants
0.5679
Cluster X0122
log Bayes Factor = 219.114
contains 9 variants
0.5635
Cluster X0063
log Bayes Factor = 107.557
contains 5 variants
0.5580
Cluster X0084
log Bayes Factor = 433.078
contains 21 variants
0.5470
Cluster X0257
log Bayes Factor = 281.184
contains 10 variants
0.5408
Cluster X0243
log Bayes Factor = 104.974
contains 6 variants
0.5381
Cluster X0085
log Bayes Factor = 138.902
contains 6 variants
0.5380
Cluster X0166
log Bayes Factor = 230.746
contains 8 variants
0.5364
Cluster X0170
log Bayes Factor = 264.081
contains 11 variants
0.5361
Cluster X0167
log Bayes Factor = 136.48
contains 6 variants
0.5350
Cluster X0189
log Bayes Factor = 149.681
contains 5 variants
0.5338
Cluster X0246
log Bayes Factor = 121.08
contains 5 variants
0.5305
Cluster X0264
log Bayes Factor = 205.833
contains 10 variants
0.5222
Cluster X0194
log Bayes Factor = 189.9
contains 5 variants
0.5140
Cluster X0212
log Bayes Factor = 300.777
contains 10 variants
0.5140
Cluster X0263
log Bayes Factor = 240.36
contains 13 variants
0.5080
Cluster X0171
log Bayes Factor = 291.293
contains 14 variants
0.5068
Cluster X0089
log Bayes Factor = 308.747
contains 13 variants
0.5027
Cluster X0003
log Bayes Factor = 195.6
contains 8 variants
0.4907
Cluster X0004
log Bayes Factor = 32.8452
contains 2 variants
0.4761
Cluster X0120
log Bayes Factor = 79.6695
contains 4 variants
0.4673
Cluster X0230
log Bayes Factor = 131.696
contains 7 variants
0.4564
Cluster X0074
log Bayes Factor = 353.38
contains 15 variants
0.4558
Cluster X0247
log Bayes Factor = 98.6507
contains 6 variants
0.4323
Cluster X0137
log Bayes Factor = 120.748
contains 4 variants
0.4266
Cluster X0315
log Bayes Factor = 42.686
contains 2 variants
0.4250
Cluster X0048
log Bayes Factor = 358.819
contains 19 variants
0.3467
Cluster X0327
log Bayes Factor = 118.248
contains 3 variants
0.3384
Cluster X0182
log Bayes Factor = 91.4459
contains 4 variants
0.3121
Cluster X0064
log Bayes Factor = 166.06
contains 10 variants
0.2936
Cluster X0269
log Bayes Factor = 155.455
contains 9 variants
0.2910
Cluster X0193
log Bayes Factor = 303.265
contains 16 variants
0.2835
Cluster X0134
log Bayes Factor = 151.731
contains 8 variants
0.2778
Cluster X0267
log Bayes Factor = 92.4806
contains 5 variants
0.2620
Cluster X0121
log Bayes Factor = 131.08
contains 9 variants
0.2292
Cluster X0138
log Bayes Factor = 43.7891
contains 4 variants
0.2142
Cluster X0199
log Bayes Factor = 350.038
contains 3 variants
0.1787
Cluster X0304
log Bayes Factor = 64.0127
contains 3 variants
0.1692
Cluster X0238
log Bayes Factor = 97.9307
contains 4 variants
0.1638
Cluster X0172
log Bayes Factor = 80.2701
contains 3 variants
0.1562
Cluster X0197
log Bayes Factor = 158.582
contains 8 variants
0.1520
Cluster X0080
log Bayes Factor = 455.123
contains 21 variants
0.1301
Cluster X0079
log Bayes Factor = 413.803
contains 22 variants
0.1233
Cluster X0297
log Bayes Factor = 63.8292
contains 4 variants
0.1233
Cluster X0240
log Bayes Factor = 104.862
contains 6 variants
0.1226
Cluster X0125
log Bayes Factor = 215.738
contains 7 variants
0.1083
Cluster X0337
log Bayes Factor = 84.9395
contains 2 variants
0.1034
Cluster X0188
log Bayes Factor = 222.629
contains 14 variants
0.0955
Cluster X0221
log Bayes Factor = 149.378
contains 10 variants
0.0929
Cluster X0326
log Bayes Factor = 112.92
contains 5 variants
0.0725
Cluster X0113
log Bayes Factor = 49.7598
contains 3 variants
0.0694
Cluster X0147
log Bayes Factor = 133.509
contains 9 variants
0.0606
Cluster X0278
log Bayes Factor = 173.437
contains 11 variants
0.0505
 
 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

The contents of TreeWAS.org are available under the Creative Commons Attribution 4.0 International License (CC BY 4.0) with attribution (citation) required.

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